Cell Biology

eIF5A controls mitoprotein import by relieving ribosome stalling at the TIM50 translocase mRNA

1. Marina Barba-Aliaga
2. Vanessa Bernal
3. Cynthia Rong
4. Brian M. Zid
5. Paula Alepuz

Reviewed by Review Commons

Focal adhesion-derived liquid-liquid phase separations regulate mRNA translation

1. Abhishek Kumar
2. Keiichiro Tanaka
3. Martin A Schwartz

• Curated by eLife

  eLife assessment

  In this valuable study, Kumar et al., provide evidence suggesting that the p130Cas drives the formation of condensates that sprout from focal adhesions to cytoplasm and suppress translation. Pending further substantiation, this study was found to be likely to provide previously unappreciated insights into the mechanisms linking focal adhesions to the regulation of protein synthesis and was thus considered to be of broad general interest. However, the evidence supporting the proposed model was incomplete; additional evidence is warranted to substantiate the relationship between p130Cas condensates and mRNA translation and establish corresponding functional consequences.

Reviewed by eLife

Cell–cell adhesion drives patterning in stratified epithelia

1. Yosuke Mai
2. Yasuaki Kobayashi
3. Hiroyuki Kitahata
4. Takashi Seo
5. Takuma Nohara
6. Sota Itamoto
7. Shoko Mai
8. Junichi Kumamoto
9. Masaharu Nagayama
10. Wataru Nishie
11. Hideyuki Ujiie
12. Ken Natsuga

Reviewed by Review Commons

BMP signaling maintains auricular chondrocyte identity and prevents microtia development by inhibiting protein kinase A

1. Ruichen Yang
2. Hongshang Chu
3. Hua Yue
4. Yuji Mishina
5. Zhenlin Zhang
6. Huijuan Liu
7. Baojie Li

• Curated by eLife

  eLife assessment

  BMP signaling plays a vital role in skeletal tissues, and the importance of its role in microtia prevention is novel and promising. This important study sheds light on the role of BMP signaling in preventing microtia in the ear, with solid data broadly supporting the claims of the authors.

Reviewed by eLife

CRISPR screens and lectin microarrays identify novel high mannose N-glycan regulators

1. C Kimberly Tsui
2. Nicholas Twells
3. Emma Doan
4. Jacqueline Woo
5. Noosha Khosrojerdi
6. Janiya Brooks
7. Ayodeji Kulepa
8. Brant Webster
9. Lara K Mahal
10. Andrew Dillin

Reviewed by Arcadia Science

The Evolutionary Origins and Ancestral Features of Septins

1. Samed Delic
2. Brent Shuman
3. Shoken Lee
4. Shirin Bahmanyar
5. Michelle Momany
6. Masayuki Onishi

Reviewed by Arcadia Science

An evolutionary cell biology perspective into the diverging mechanisms of clathrin-mediated endocytosis in dikarya fungi

1. Andrea Picco
2. Christopher P. Toret
3. Anne-Sophie Rivier-Cordey
4. Marko Kaksonen

Reviewed by Arcadia Science

Control of ciliary transcriptional programs during spermatogenesis by antagonistic transcription factors

1. Weihua Wang
2. Junqiao Xing
3. Xiqi Zhang
4. Hongni Liu
5. Haochen Jiang
6. Cheng Xu
7. Xue Zhao
8. Zhangfeng Hu

• Curated by eLife

  eLife assessment

  This study reports useful data suggesting the critical roles of two ancient proteins, XAP5 and XAP5L, in controlling the transcriptional program of ciliogenesis during mouse spermatogenesis. However, this study is considered incomplete because the data only partially support the conclusion. This work will be of interest to biomedical researchers who work on ciliogenesis and reproduction.

Reviewed by eLife

Human cytomegalovirus deploys molecular mimicry to recruit VPS4A to sites of virus assembly

1. Benjamin G. Butt
2. Daniela Fischer
3. Alison R. Rep
4. Martin Schauflinger
5. Clarissa Read
6. Thomas Böck
7. Manuel Hirner
8. Stephen C. Graham
9. Jens von Einem

Reviewed by Review Commons

Distinct transcriptomic profile of satellite cells contributes to preservation of neuromuscular junctions in extraocular muscles of ALS mice

1. Ang Li
2. Jianxun Yi
3. Xuejun Li
4. Li Dong
5. Lyle W Ostrow
6. Jianjie Ma
7. Jingsong Zhou

• Curated by eLife

  eLife assessment

  The manuscript by Jingsong Zhou and colleagues uncovers why the extraocular muscles (EOMs) are preserved while other muscles undergo degenerative changes in amyotrophic lateral sclerosis (ALS). In this work, the authors have used a mouse model of familial ALS that carries a G93A mutation in the Sod1 gene to demonstrate that NaBu treatment partially restores the integrity of NMJ in the limb and diaphragm muscles of G93A mice. The findings of the study offer important information that EOMs are spared in ALS because they produce protective factors for the NMJ and, more specifically, factors secreted by EOM-derived satellite cells. While most of the experimental approaches are convincing, the use of sodium butyrate (NaBu) in this study needs further investigation, as NaBu might have a variety of biological effects. Overall, this work may help develop future therapeutic interventions for patients with ALS.

Reviewed by eLife