Cell Biology

Organelle membrane-associated proteins recruit cGAS via phase separation to facilitate its membrane localization

1. Chengrui Shi
2. Chaofei Su
3. Kaixiang Zhang
4. Hang Yin

• Curated by eLife

  eLife Assessment

  This useful study investigates how intrinsically disordered domains can interact to dictate the sub-cellular localization of a major innate immune sensor termed cGAS. The data from various cellular and biochemical assays are mostly solid, but the main conclusions from these experiments need to be validated further. This paper is relevant to immunologists, especially those interested in cytosolic DNA-sensing pathways.

Reviewed by eLife

JIP4 deficiency causes a lysosomal storage disease arising from impaired cystine efflux

1. Layla M. Nassar
2. Xiaojian Shi
3. Agnes Roczniak-Ferguson
4. Hongying Shen
5. Shawn M. Ferguson

Reviewed by Arcadia Science

Stress response of membrane-based cell organelles in budding yeast

1. Sheng Peng
2. Bai Li-zhe
3. Cao Hong
4. Li Dan

Reviewed by Arcadia Science

When mitochondria fall apart: Unbalanced mitochondrial segregation triggers loss of mtDNA in the absence of mitochondrial fusion

1. Lisa Dengler
2. Francesco Padovani
3. Bianca Lemke
4. Rebecca Brugger
5. Benedikt Westermann
6. Boris Maček
7. Kurt M. Schmoller
8. Jennifer C. Ewald

Reviewed by Review Commons

Targeting RhoA activity rejuvenates aged hematopoietic stem cells

1. Eva Mejía-Ramírez
2. Pablo Iañez Picazo
3. Barbara Walter
4. Sara Montserrat-Vazquez
5. Francesco Affuso
6. Stefan Wieser
7. Fabio Pezzano
8. Loïc Reymond
9. Jorge Castillo-Robles
10. Francesca Matteini
11. Loris Mularoni
12. Dídac Maciá
13. Ángel Raya
14. Verena Ruprecht
15. Yi Zheng
16. Paula Petrone
17. M. Carolina Florian

Reviewed by preLights