Necrosulfonamide causes oxidation of PCM1 and impairs ciliogenesis and autophagy

  1. Clotilde C.N. Renaud
  2. Carolina Alves Nicolau
  3. Clément Maghe
  4. Kilian Trillet
  5. Jane Jardine
  6. Sophie Escot
  7. Nicolas David
  8. Julie Gavard
  9. Nicolas Bidère

Reviewed by

Read the full article See related articles

Listed in

Log in to save this article

Abstract

No abstract available

Article activity feed

  1. Version published to 10.1016/j.isci.2024.109580
  2. preLights

    Excerpt

    Necrosulfonamide disrupts ciliogenesis and autophagy by inducing PCM1 oxidation and aggregation via ROS production, independent of MLKL.

  3. Version published to 10.1101/2023.05.05.539527v2 on bioRxiv
  4. Version published to 10.1101/2023.05.05.539527v1 on bioRxiv