Cell Biology

The Anti-Inflammatory Role of GPNMB in Post-Traumatic Osteoarthritis

1. Asaad A Al-Adlaan
2. Bryson Cook
3. Nazar J Hussein
4. Fatima A Jaber
5. Trinity Kronk
6. Ernesto Solorzano Z
7. Salvatore Frangiamore
8. Hope C Ball
9. Fayez F Safadi

• Curated by eLife

  eLife Assessment

  This study demonstrates the cartilage-protective effects of osteoactivin in inflammatory experimental models. The work offers valuable insights advancing current knowledge regarding regulation of joint inflammation and tissue degeneration. The evidence provided is compelling and suggests that osteoactivin may serve as a promising therapeutic target for inflammatory joint diseases.

Reviewed by eLife

Labeling of nascent RNA in the C. elegans intestine

1. Omid Gholamalamdari
2. Stephanie C. Weber

Reviewed by Arcadia Science

Vesiculation pathways in clathrin-mediated endocytosis

1. Xinran Wang
2. Julien Berro
3. Rui Ma

• Curated by eLife

  eLife Assessment

  This valuable study proposes a theoretical model of clathrin coat formation based on membrane elasticity that seeks to determine whether this process occurs by increasing the area of a protein-coated patch with constant curvature, or by increasing the curvature of a protein-coated patch that forms in an initially flat conformation (so called constant curvature or constant area models). Identifying energetically favorable pathways and comparing the obtained shapes with experiments provides solid support to the constant-area pathway. This work will be of interest for biologists and biophysicists interested in membrane remodelling and endocytosis. It provides an innovative approach to tackle the question of constant curvature vs. constant area coat protein formation, although some of the model's assumption are only partially supported by experimental evidence.

Reviewed by eLife

Mechanotransductive feedback control of endothelial cell motility and vascular morphogenesis

1. Devon E Mason
2. Paula Camacho
3. Megan E Goeckel
4. Brendan R Tobin
5. Sebastián L Vega
6. Pei-Hsun Wu
7. Dymonn Johnson
8. Su-Jin Heo
9. Denis Wirtz
10. Jason A Burdick
11. Levi Wood
12. Brian Y Chow
13. Amber N Stratman
14. Joel D Boerckel

• Curated by eLife

  eLife Assessment

  This fundamental study substantially advances our current understanding of mechanotransduction within endothelial cells. The evidence provided by the authors in the revised manuscript is compelling, which taken together, provides strong support for the authors' major findings. The work will be of broad interest to cell biologists and vascular biologists.

Reviewed by eLife

Condensation of Sidekick at tricellular junctions organizes mechanical forces for cell-cell adhesion remodeling

1. Hiroyuki Uechi
2. Daxiao Sun
3. Yuki Saeki
4. Tetsuya Hiraiwa
5. Alf Honigmann
6. Anthony A. Hyman
7. Erina Kuranaga

Reviewed by preLights