Cell Biology

Vesiculation pathways in clathrin-mediated endocytosis

1. Xinran Wang
2. Julien Berro
3. Rui Ma

• Curated by eLife

  eLife Assessment

  This valuable study proposes a theoretical model of clathrin coat formation based on membrane elasticity that seeks to determine whether this process occurs by increasing the area of a protein-coated patch with constant curvature, or by increasing the curvature of a protein-coated patch that forms in an initially flat conformation (so called constant curvature or constant area models). Identifying energetically favorable pathways and comparing the obtained shapes with experiments provides solid support to the constant-area pathway. This work will be of interest for biologists and biophysicists interested in membrane remodelling and endocytosis. It provides an innovative approach to tackle the question of constant curvature vs. constant area coat protein formation, although some of the model's assumption are only partially supported by experimental evidence.

Reviewed by eLife

Mechanotransductive feedback control of endothelial cell motility and vascular morphogenesis

1. Devon E Mason
2. Paula Camacho
3. Megan E Goeckel
4. Brendan R Tobin
5. Sebastián L Vega
6. Pei-Hsun Wu
7. Dymonn Johnson
8. Su-Jin Heo
9. Denis Wirtz
10. Jason A Burdick
11. Levi Wood
12. Brian Y Chow
13. Amber N Stratman
14. Joel D Boerckel

• Curated by eLife

  eLife Assessment

  This fundamental study substantially advances our current understanding of mechanotransduction within endothelial cells. The evidence provided by the authors in the revised manuscript is compelling, which taken together, provides strong support for the authors' major findings. The work will be of broad interest to cell biologists and vascular biologists.

Reviewed by eLife

Condensation of Sidekick at tricellular junctions organizes mechanical forces for cell-cell adhesion remodeling

1. Hiroyuki Uechi
2. Daxiao Sun
3. Yuki Saeki
4. Tetsuya Hiraiwa
5. Alf Honigmann
6. Anthony A. Hyman
7. Erina Kuranaga

Reviewed by preLights

Compromised DNA replication in gut cells underlies tardigrade sensitivity to genotoxic stress

1. Gonzalo Quiroga-Artigas
2. Pauline Fontanié
3. Benjamin Lacroix
4. Maria Dolores Molina
5. María Moriel-Carretero

Reviewed by Review Commons

Importin α characterizes a micronuclear environment associated with genomic instability in human cancer cells

1. Yoichi Miyamoto
2. Reo Kisanuki
3. Rieko Oshima
4. Shige H. Yoshimura
5. Mutsumi Yokota
6. Kazumitsu Maehara
7. Yoshiatsu Aomine
8. Chiaki Hata
9. Taro Tachibana
10. Masaharu Hazawa
11. Hiroyuki Okada
12. Hiroshi Kimura
13. Masato Koike
14. Yasuyuki Ohkawa
15. Toyomasa Katagiri
16. Yoshihiro Yoneda
17. Masahiro Oka
18. Hisato Saitoh

Reviewed by Review Commons

Distal Gene Expression Governed by Lamins and Nesprins via Chromatin Conformation Change

1. Haihui Zhang
2. Zhengyang Lei
3. Fatemeh Momen-Heravi
4. Peiwu Qin

• Curated by eLife

  eLife Assessment

  This study provides valuable information on the impact of Lamin A/C knockdown on gene expression using RNA-Seq analysis, as well as on telomere dynamics through live cell imaging. However, the conclusions remain inadequately supported by the current data, and several of the major technical concerns raised in the first round have not yet been fully resolved.

Reviewed by eLife