Cell Biology

  1. Suppression of interferon signaling via small-molecule modulation of TFAM

    1. Dionisia Sideris
    2. Husan Lee
    3. Lyndsay Olson
    4. Kalyan Nallaparaju
    5. Keiichiro Okuyama
    6. Jeffrey Ciavarri
    7. Robert Lafyatis
    8. Mads Larsen
    9. Bo Lin
    10. Irene Alfaras
    11. Jason Kennerdell
    12. Toren Finkel
    13. Yuan Liu
    14. Bill Chen
    15. Lin Lyu

    • Curated by eLife

      eLife Assessment

      Using high-throughput small-molecule screening, this study discloses novel modulators of the mitochondrial transcription factor A (TFAM), a key regulator of mitochondrial function. Reviewers viewed the targeting of TFAM as innovative and the study's conclusions as potentially important (especially the effects on inflammation). However, the lack of evidence for a direct effect of the compounds on TFAM activity weakens the paper's key conclusion and renders the study incomplete.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  2. Condensation of Sidekick at tricellular junctions organizes mechanical forces for cell-cell adhesion remodeling

    1. Hiroyuki Uechi
    2. Daxiao Sun
    3. Yuki Saeki
    4. Tetsuya Hiraiwa
    5. Alf Honigmann
    6. Anthony A. Hyman
    7. Erina Kuranaga

    Reviewed by preLights

    1 evaluationAppears in 1 listLatest version Latest activity

  3. Compromised DNA replication in gut cells underlies tardigrade sensitivity to genotoxic stress

    1. Gonzalo Quiroga-Artigas
    2. Pauline Fontanié
    3. Benjamin Lacroix
    4. Maria Dolores Molina
    5. María Moriel-Carretero

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  4. Importin α characterizes a micronuclear environment associated with genomic instability in human cancer cells

    1. Yoichi Miyamoto
    2. Reo Kisanuki
    3. Rieko Oshima
    4. Shige H. Yoshimura
    5. Mutsumi Yokota
    6. Kazumitsu Maehara
    7. Yoshiatsu Aomine
    8. Chiaki Hata
    9. Taro Tachibana
    10. Masaharu Hazawa
    11. Hiroyuki Okada
    12. Hiroshi Kimura
    13. Masato Koike
    14. Yasuyuki Ohkawa
    15. Toyomasa Katagiri
    16. Yoshihiro Yoneda
    17. Masahiro Oka
    18. Hisato Saitoh

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  5. Distal Gene Expression Governed by Lamins and Nesprins via Chromatin Conformation Change

    1. Haihui Zhang
    2. Zhengyang Lei
    3. Fatemeh Momen-Heravi
    4. Peiwu Qin

    • Curated by eLife

      eLife Assessment

      This study provides valuable information on the impact of Lamin A/C knockdown on gene expression using RNA-Seq analysis, as well as on telomere dynamics through live cell imaging. However, the conclusions remain inadequately supported by the current data, and several of the major technical concerns raised in the first round have not yet been fully resolved.

    Reviewed by eLife

    8 evaluationsAppears in 1 listLatest version Latest activity

  6. Opposing roles for lipocalins and a CD36 family scavenger receptor in apical extracellular matrix-dependent protection of narrow tube integrity

    1. Alexandra C. Belfi
    2. Sage G. Aviles
    3. Rachel Forman-Rubinsky
    4. Hasreet K. Gill
    5. Jennifer D. Cohen
    6. Aleksandra Nawrocka
    7. Axelle Bourez
    8. Pierre van Antwerpen
    9. Patrick Laurent
    10. Meera V. Sundaram

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  7. TAM receptors control actomyosin dynamics in osteoclasts via RHOA-COFILIN-MYOSIN II signaling

    1. Janik Engelmann
    2. Jennifer Zarrer
    3. Max Schmerder
    4. Christian Mess
    5. Deniz Ragipoglu
    6. Kristoffer Riecken
    7. Tal Burstyn-Cohen
    8. Emily J. Alberto
    9. Sourav Ghosh
    10. Carla Rothlin
    11. Klaus Pantel
    12. Carsten Bokemeyer
    13. Eric Hesse
    14. Hanna Taipaleenmäki
    15. Sonja Loges
    16. Isabel Ben-Batalla

    Reviewed by preLights

    1 evaluationAppears in 1 listLatest version Latest activity

  8. Membrane potential modulates ERK activity and cell proliferation in human cells

    1. Mari Sasaki
    2. Masanobu Nakahara
    3. Takuya Hashiguchi
    4. Fumihito Ono

    • Curated by eLife

      eLife Assessment

      This important paper employs multiple experimental approaches and presents evidence that changes in membrane voltage directly affect ERK signaling to regulate cell division. This result is relevant because it supports an ion channel-independent pathway by which changes in membrane voltage can affect cell growth. The evidence now presented is solid and the data support the conclusions. This paper should be of interest to a broad readershp in the areas of cell and developemental biology and electrophysiology.

    Reviewed by eLife

    15 evaluationsAppears in 1 listLatest version Latest activity

  9. Co-option of lysosomal machinery shapes the symbiosis supporting coral reefs

    1. Shumpei Maruyama
    2. Catherine F Henderson
    3. Natalie Swinhoe
    4. Griffin P Kowalewski
    5. Emily K Meier
    6. Ty R Engelke
    7. Phillip A Cleves

    Reviewed by Arcadia Science

    1 evaluationAppears in 1 listLatest version Latest activity

  10. Organelle membrane-associated proteins recruit cGAS via phase separation to facilitate its membrane localization

    1. Chengrui Shi
    2. Chaofei Su
    3. Kaixiang Zhang
    4. Hang Yin

    • Curated by eLife

      eLife Assessment

      This useful study investigates how intrinsically disordered domains can interact to dictate the sub-cellular localization of a major innate immune sensor termed cGAS. The data from various cellular and biochemical assays are mostly solid, but the main conclusions from these experiments need to be validated further. This paper is relevant to immunologists, especially those interested in cytosolic DNA-sensing pathways.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity
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