Cancer Biology

Identification of CD133+ intercellsomes in intercellular communication to offset intracellular signal deficit

1. Kota Kaneko
2. Yan Liang
3. Qing Liu
4. Shuo Zhang
5. Alexander Scheiter
6. Dan Song
7. Gen-Sheng Feng

• Curated by eLife

  eLife assessment

  This important study was designed to examine the bypass of Ras/Erk signaling defects that enable limited regeneration in a mouse model of hepatic regeneration. This hepatocyte proliferation is associated with the expression by groups of cells of mRNA-loaded CD133+ intracellular vesicles that mediate an intercellular signaling pathway that supports proliferation. These are new observations, supported by convincing data, that have broad significance to the fields of regeneration and cancer.

Reviewed by eLife

Circulating tumor extracellular vesicles to monitor metastatic prostate cancer genomics and transcriptomic evolution

1. Irene Casanova-Salas
2. Daniel Aguilar
3. Sarai Cordoba-Terreros
4. Laura Agundez
5. Julian Brandariz
6. Nicolas Herranz
7. Alba Mas
8. Macarena Gonzalez
9. Rafael Morales-Barrera
10. Alexandre Sierra
11. Mario Soriano-Navarro
12. Pablo Cresta
13. Gisela Mir
14. Sara Simonetti
15. Gonçalo Rodrigues
16. Sara Arce-Gallego
17. Luisa Delgado-Serrano
18. Irene Agustí
19. Elena Castellano-Sanz
20. Richard Mast
21. Matias de Albert
22. Ana Celma
23. Anna Santamaria
24. Lucila Gonzalez
25. Natalia Castro
26. Maria del Mar Suanes
27. Javier Hernández-Losa
28. Lara Nonell
29. Hector Peinado
30. Joan Carles
31. Joaquin Mateo

Reviewed by PREreview

Identifying targetable metabolic dependencies across colorectal cancer progression

1. Danny N. Legge
2. Tracey J. Collard
3. Ewelina Stanko
4. Ashley J. Hoskin
5. Amy K. Holt
6. Caroline J. Bull
7. Madhu Kollareddy
8. Jake Bellamy
9. Sarah Groves
10. Eric H. Ma
11. Emma Hazelwood
12. David Qualtrough
13. Borko Amulic
14. Karim Malik
15. Ann C. Williams
16. Nicholas Jones
17. Emma E. Vincent

Reviewed by Review Commons

Complementary CRISPR screen highlights the contrasting role of membrane-bound and soluble ICAM-1 in regulating antigen-specific tumor cell killing by cytotoxic T cells

1. Ann-Kathrin Herzfeldt
2. Marta Puig Gamez
3. Eva Martin
4. Lukasz Miloslaw Boryn
5. Praveen Baskaran
6. Heinrich J Huber
7. Michael Schuler
8. John E Park
9. Lee Kim Swee

• Curated by eLife

  eLife assessment

  This important research uses complementary CRISPR screening strategies to reveal novel pathways that prevent T cells from killing tumor cells. The evidence presented to support the claims is solid, although some additional assays defining the features of these novel pathways and their clinical relevance are still required. Overall, this work will be of broad interest to immunologists, cancer biologists, and those interested in cell adhesion and cell-cell communication.

Reviewed by eLife

A 3D microtumour system that faithfully represents ovarian cancer minimal residual disease

1. Xingyun Yang
2. Mara Artibani
3. Yongcheng Jin
4. Aneesh Aggarwal
5. Yujia Zhang
6. Sandra Muñoz-Galvan
7. Ellina Mikhailova
8. Lena Rai
9. Nobina Mukherjee
10. Ravinash Krishna Kumar
11. Ashwag Albukhari
12. Linna Zhou
13. Ahmed Ashour Ahmed
14. Hagan Bayley

Reviewed by PREreview

Small Extracellular Vesicles Promote Stiffness-mediated Metastasis

1. Alexandra Sneider
2. Ying Liu
3. Bartholomew Starich
4. Wenxuan Du
5. Praful R. Nair
6. Carolyn Marar
7. Najwa Faqih
8. Gabrielle E. Ciotti
9. Joo Ho Kim
10. Sejal Krishnan
11. Salma Ibrahim
12. Muna Igboko
13. Alexus Locke
14. Daniel M. Lewis
15. Hanna Hong
16. Michelle N. Karl
17. Raghav Vij
18. Gabriella C. Russo
19. Estibaliz Gómez-de-Mariscal
20. Mehran Habibi
21. Arrate Muñoz-Barrutia
22. Luo Gu
23. T.S. Karin Eisinger-Mathason
24. Denis Wirtz

Reviewed by preLights

The BRD4S-LOXL2-MED1 interaction at the forefront of cell cycle transcriptional control in triple-negative breast cancer

1. Laura Pascual-Reguant
2. Tian V. Tian
3. Debayan Datta
4. Damiano Cianferoni
5. Savvas Kourtis
6. Antoni Gañez-Zapater
7. Chiara Cannatá
8. Queralt Serra-Camprubi
9. Lorena Espinar
10. Maria Guirola
11. Jessica Querol
12. Andrea Miró Canturri
13. Joaquin Arribas
14. Luis Serrano
15. Sandra Peiró
16. Sara Sdelci

Reviewed by Review Commons

Major data analysis errors invalidate cancer microbiome findings

1. Abraham Gihawi
2. Yuchen Ge
3. Jennifer Lu
4. Daniela Puiu
5. Amanda Xu
6. Colin S. Cooper
7. Daniel S. Brewer
8. Mihaela Pertea
9. Steven L. Salzberg

Reviewed by Arcadia Science

Mutant SF3B1 promotes malignancy in PDAC

1. Patrik Simmler
2. Eleonora I Ioannidi
3. Tamara Mengis
4. Kim Fabiano Marquart
5. Simran Asawa
6. Kjong Van-Lehmann
7. Andre Kahles
8. Tinu Thomas
9. Cornelia Schwerdel
10. Nicola Aceto
11. Gunnar Rätsch
12. Markus Stoffel
13. Gerald Schwank

• Curated by eLife

  eLife assessment

  This work examines a role for altered splicing in pancreatic tumorigenesis by interrogating effects of a specific mutation in the Sf3b splicing factor in pancreatic organoid and cell line growth primarily, with some in vivo work also performed. There is significant potential in the study but there is a concern about the lack of in vivo validation of claims that are most relevant to metastatic progression and the focus on one specific mechanism at the expense of other possible effects on splicing of factors important for disease progression.

Reviewed by eLife

TMPRSS2, a SARS-CoV-2 internalization protease is downregulated in head and neck cancer patients

1. Andrea Sacconi
2. Sara Donzelli
3. Claudio Pulito
4. Stefano Ferrero
5. Francesca Spinella
6. Aldo Morrone
7. Marta Rigoni
8. Fulvia Pimpinelli
9. Fabrizio Ensoli
10. Giuseppe Sanguineti
11. Raul Pellini
12. Nishant Agrawal
13. Evgeny Izumchenko
14. Gennaro Ciliberto
15. Aldo Giannì
16. Paola Muti
17. Sabrina Strano
18. Giovanni Blandino

Reviewed by ScreenIT