Cancer Biology

WWOX promotes osteosarcoma development via upregulation of Myc

1. Rania Akkawi
2. Osama Hidmi
3. Ameen Haj-Yahia
4. Jonathon Monin
5. Judith Diment
6. Yotam Drier
7. Gary S. Stein
8. Rami I. Aqeilan

Reviewed by Review Commons

High-grade serous ovarian carcinoma organoids as models of chromosomal instability

1. Maria Vias
2. Lena Morrill Gavarró
3. Carolin M Sauer
4. Deborah A Sanders
5. Anna M Piskorz
6. Dominique-Laurent Couturier
7. Stéphane Ballereau
8. Bárbara Hernando
9. Michael P Schneider
10. James Hall
11. Filipe Correia-Martins
12. Florian Markowetz
13. Geoff Macintyre
14. James D Brenton

• Curated by eLife

  eLife assessment

  This valuable study reveals that patient-derived organoids recapitulate similar genomic signatures as that of the parental tissue, which could be a useful model to evaluate chromosome instability, drug sensitivity, and intratumoral heterogeneity. However, whereas some of the sequencing data are compelling, the theoretical analysis is incomplete and would benefit from a more rigorous definition. With the theoretical part strengthened, the work will be of interest to medical biologists working on ovarian carcinoma.

Reviewed by eLife

PTEN deficiency exposes a requirement for an ARF GTPase module for integrin‐dependent invasion in ovarian cancer

1. Konstantina Nikolatou
2. Emma Sandilands
3. Alvaro Román‐Fernández
4. Erin M Cumming
5. Eva Freckmann
6. Sergio Lilla
7. Lori Buetow
8. Lynn McGarry
9. Matthew Neilson
10. Robin Shaw
11. David Strachan
12. Crispin Miller
13. Danny T Huang
14. Iain A McNeish
15. James C Norman
16. Sara Zanivan
17. David M Bryant

Reviewed by Review Commons

Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function

1. Edward P Carter
2. Kubra K Yoneten
3. Nuria Gavara
4. Eleanor J Tyler
5. Valentine Gauthier
6. Elizabeth R Murray
7. Peter ten Dijke
8. Angus J Cameron
9. Oliver Pearce
10. Richard P Grose

Reviewed by Review Commons

Metabolic clogging of mannose triggers dNTP loss and genomic instability in human cancer cells

1. Yoichiro Harada
2. Yu Mizote
3. Takehiro Suzuki
4. Akiyoshi Hirayama
5. Satsuki Ikeda
6. Mikako Nishida
7. Toru Hiratsuka
8. Ayaka Ueda
9. Yusuke Imagawa
10. Kento Maeda
11. Yuki Ohkawa
12. Junko Murai
13. Hudson H Freeze
14. Eiji Miyoshi
15. Shigeki Higashiyama
16. Heiichiro Udono
17. Naoshi Dohmae
18. Hideaki Tahara
19. Naoyuki Taniguchi

• Curated by eLife

  eLife assessment

  The authors present valuable findings regarding the mechanism of high mannose induced cellular toxicity in cancer cells. The evidence supporting genomic instability as the anti-cancer activity of mannose is convincing with multiple orthogonal approaches showing consistent results, but the conclusions related to metabolic remodeling could be further strengthened by additional metabolomics data. While the findings are limited to genetically modified cancer cell lines cultured in vitro, this work will be of interest to cell biologists working on cancer metabolism.

Reviewed by eLife

The CD73 immune checkpoint promotes tumor cell metabolic fitness

1. David Allard
2. Isabelle Cousineau
3. Eric H Ma
4. Bertrand Allard
5. Yacine Bareche
6. Hubert Fleury
7. John Stagg

• Curated by eLife

  eLife assessment

  This important study demonstrates a non-canonical, cancer-cell intrinsic role of the ectonucleotidase CD73 in the regulation of cancer cell metabolism. The evidence supporting the claims is solid, although further experimental details and conditions would strengthen the evidence provided.

Reviewed by eLife

fMetastatic potential in clonal melanoma cells is driven by a rare, early-invading subpopulation

1. Amanpreet Kaur
2. Luciann Cuenca
3. Karun Kiani
4. Gianna T. Busch
5. Dylan Fingerman
6. Margaret C. Dunagin
7. Jingxin Li
8. Ian Dardani
9. Eric M. Sanford
10. Jordan Pemberton
11. Yogesh Goyal
12. Ashani T. Weeraratna
13. Meenhard Herlyn
14. Arjun Raj

Reviewed by Review Commons

Mesenchymal stem cell suppresses the efficacy of CAR-T toward killing lymphoma cells by modulating the microenvironment through stanniocalcin-1

1. Rui Zhang
2. Qingxi Liu
3. Sa Zhou
4. Hongpeng He
5. Mingfeng Zhao
6. Wenjian Ma

• Curated by eLife

  eLife assessment

  This study provides potentially important insights into the role of mesenchymal stem cells in CAR-T therapy, and suggest that the STC1 gene could be a key factor in influencing the efficacy of this treatment. This finding has the potential to improve current therapeutic strategies based on cell therapy and may indicate new biology related to how mesenchymal stem cells affect the immune state within the tumor microenvironment. Further research is necessary to clarify the signaling pathways, but the data presented by the authors are generally well-supported and convincing.

Reviewed by eLife

Targeting oncogenic KRasG13C with nucleotide-based covalent inhibitors

1. Lisa Goebel
2. Tonia Kirschner
3. Sandra Koska
4. Amrita Rai
5. Petra Janning
6. Stefano Maffini
7. Helge Vatheuer
8. Paul Czodrowski
9. Roger S Goody
10. Matthias P Müller
11. Daniel Rauh

• Curated by eLife

  eLife assessment

  The authors present interesting information regarding the possibility of targeting the oncogenic K-Ras(G13C) mutant with nucleotide competitors. The experiments represent a solid support of the claims and show that this approach can work despite concerns about the high affinity of GTP and its high cellular concentration. These results will be of high interest for all working in the Ras field and in targeting oncogenes with small molecules. A weakness of the manuscript is the lack of direct physiological insights.

Reviewed by eLife

Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion

1. Elena Tomas Bort
2. Megan D Joseph
3. Qiaoying Wang
4. Edward P Carter
5. Nicolas J Roth
6. Jessica Gibson
7. Ariana Samadi
8. Hemant M Kocher
9. Sabrina Simoncelli
10. Peter J McCormick
11. Richard P Grose

Reviewed by Review Commons