Cancer Biology

Disassembly of embryonic keratin filaments promotes pancreatic cancer metastases

1. Ryan R. Kawalerski
2. Mariana Torrente Gonçalves
3. Chun-Hao Pan
4. Robert Tseng
5. Lucia Roa-Peña
6. Cindy V. Leiton
7. Luke A. Torre-Healy
8. Taryn Boyle
9. Sumedha Chowdhury
10. Natasha T. Snider
11. Kenneth R. Shroyer
12. Luisa F. Escobar-Hoyos

• Curated by eLife

  eLife assessment

  The authors address the function of keratin 17 (K17), a marker of the most aggressive pancreatic ductal adenocarcinomas (PDACs). While this potentially useful study addresses a significant area of pancreatic cancer research, the lack of evidence demonstrating nuclear localization of K17 in human PDAC and the excessive reliance on a single cell line reduce the significance of the work. Moreover, the weak phenotypes of K17 phosphosite mutants provide incomplete support for the authors' mechanistic model.

Reviewed by eLife

Improving PD-1 blockade plus chemotherapy for complete remission of lung cancer by nanoPDLIM2

1. Fan Sun
2. Pengrong Yan
3. Yadong Xiao
4. Hongqiao Zhang
5. Steven D Shapiro
6. Gutian Xiao
7. Zhaoxia Qu

• Curated by eLife

  eLife assessment

  This study presents a valuable finding for the immunotherapy of cancer. The data support the role of PDLIM2 as a tumor suppressor, and more immediately, its relevance for strategies to improve the efficacy of immunotherapy. The evidence supporting the conclusions is compelling and the work will be of interest to biomedical scientists working on cancer immunology.

Reviewed by eLife

Molecular classification and tumor microenvironment characteristics in pheochromocytomas

1. Sen Qin
2. Yawei Xu
3. Shimiao Yu
4. Wencong Han
5. Shiheng Fan
6. Wenxiang Ai
7. Kenan Zhang
8. Yizhou Wang
9. Xuehong Zhou
10. Qi Shen
11. Kan Gong
12. Luyang Sun
13. Zheng Zhang

• Curated by eLife

  eLife assessment

  This valuable study advances our understanding of the potential therapeutic strategies for the treatment of pheochromocytomas using single-cell transcriptomics. The authors propose a new molecular classification criterion based on the characterization of tumor microenvironmental features, based on solid evidence. The work, which could be improved further through delineating the choice of the PASS scoring system, will be of broad interest to clinicians, medical researchers, and scientists working in the field of pheochromocytoma.

Reviewed by eLife

Discovery of highly active kynureninases for cancer immunotherapy through protein language model

1. Hyunuk Eom
2. Sukhwan Park
3. Kye Soo Cho
4. Jihyeon Lee
5. Hyunbin Kim
6. Stephanie Kim
7. Jinsol Yang
8. Young-Hyun Han
9. Juyong Lee
10. Chaok Seok
11. Myeong Sup Lee
12. Woon Ju Song
13. Martin Steinegger

Reviewed by Arcadia Science

Chemotherapeutic regulation of the ROS/MondoA-dependent TXNIP/GDF15 axis; and derivation of a new organoid metric as a predictive biomarker

1. Jinhai Deng
2. Teng Pan
3. Yourae Hong
4. Zaoqu Liu
5. Xingang Zhou
6. Zhengwen An
7. Lifeng Li
8. Giovanna Alfano
9. Gang Li
10. Luigi Dolcetti
11. Rachel Evans
12. Jose M Vicencio
13. Petra Vlckova
14. Yue Chen
15. James Monypenny
16. Camila Araujo De Carvalho Gomes
17. Kenrick Ng
18. Caitlin McCarthy
19. Xiaoping Yang
20. Zedong Hu
21. Joanna C. Porter
22. Christopher J Tape
23. Mingzhu Yin
24. Manuel Rodriguez-Justo
25. Sabine Tejpar
26. Richard Beatson
27. Tony Ng

Reviewed by Review Commons

Long-term hematopoietic transfer of the anti-cancer and lifespan-extending capabilities of a genetically engineered blood system by transplantation of bone marrow mononuclear cells

1. Jing-Ping Wang
2. Chun-Hao Hung
3. Yae-Huei Liou
4. Ching-Chen Liu
5. Kun-Hai Yeh
6. Keh-Yang Wang
7. Zheng-Sheng Lai
8. Biswanath Chatterjee
9. Tzu-Chi Hsu
10. Tung-Liang Lee
11. Yu-Chiau Shyu
12. Pei-Wen Hsiao
13. Liuh-Yow Chen
14. Trees-Juen Chuang
15. Chen-Hsin Albert Yu
16. Nan-Shih Liao
17. C-K James Shen

• Curated by eLife

  eLife assessment

  This useful manuscript focuses on understanding how an Eklf mutation confers anticancer and longevity advantages in vivo. The data demonstrate that Eklf (K74R) imparts such advantages in a background and age independent manner in both female and male mice, and that the benefits are transferable by bone marrow transplantation. Despite added data since a previous version, the paper unfortunately remains incomplete, as it is still unclear whether Eklf affects resistance to malignant progression/metastasis by modulating Pd1 or Pdl1, or by increasing NK cells. The authors provide evidence that supports in principle both mechanisms, and they do not resolve which mechanism is primarily involved.

Reviewed by eLife

Integrative study of skeletal muscle mitochondrial dysfunction in a murine pancreatic cancer-induced cachexia model

1. Tristan Gicquel
2. Fabio Marchiano
3. Gabriela Reyes-Castellanos
4. Stephane Audebert
5. Luc Camoin
6. Bianca H Habermann
7. Benoit Giannesini
8. Alice Carrier

• Curated by eLife

  eLife assessment

  This useful study uses a mouse model of pancreatic cancer to examine mitochondrial mass and structure in atrophying muscle along with aspects of mitochondrial metabolism in the same tissue. Most relevant are the solid transcriptomics and proteomics approaches to map out related changes in gene expression networks in muscle during cancer cachexia.

Reviewed by eLife

N-cadherin dynamically regulates pediatric glioma cell migration in complex environments

1. Dayoung Kim
2. James M. Olson
3. Jonathan A. Cooper

Reviewed by Review Commons

GOT1 primes the cellular response to hypoxia by supporting glycolysis and HIF1α stabilisation

1. Fiona Grimm
2. Agustín Asuaje
3. Aakriti Jain
4. Mariana Silva dos Santos
5. Jens Kleinjung
6. Patrícia M. Nunes
7. Stefanie Gehrig
8. Louise Fets
9. James I. MacRae
10. Dimitrios Anastasiou

Reviewed by Review Commons

Bcl-xL is translocated to the nucleus via CtBP2 to epigenetically promote metastasis

1. Tiantian Zhang
2. Sha Li
3. Yingcai Adrian Tan
4. Xiang Chen
5. Cheryl Zhang
6. Zhengming Chen
7. Bikash Mishra
8. Joseph HyungJoon Na
9. Soyoung Choi
10. Sandra J. Shin
11. Priyadarshan Damle
12. Kranthi Kumar Chougoni
13. Steven R. Grossman
14. Dunrui Wang
15. Xuejun Jiang
16. Yi Li
17. Erika Hissong
18. Yao-Tseng Chen
19. Jenny Z. Xiang
20. Yi-Chieh Nancy Du

Reviewed by Review Commons