Cancer Biology

Paralog dispensability shapes homozygous deletion patterns in tumor genomes

1. Barbara De Kegel
2. Colm J Ryan

Reviewed by Review Commons

Oncogenic functions of the m6A demethylase FTO in breast cancer cells involving translational upregulation of C/EBPβ-LIP

1. Hidde R. Zuidhof
2. Christine Müller
3. Gertrud Kortman
4. René Wardenaar
5. Ekaterina Stepanova
6. Fabricio Loayza-Puch
7. Cornelis F. Calkhoven

Reviewed by Review Commons

The Drosophila cancer-germline, head-to-head gene pair TrxT and dhd is dispensable for normal brain development but plays a major role in l(3)malignant brain tumour growth

1. Cristina Molnar
2. Jan Peter Heinen
3. Jose Reina
4. Salud Llamazares
5. Emilio Palumbo
6. Giulia Pollarolo
7. Cayetano Gonzalez

Reviewed by Review Commons

Exploiting metabolic vulnerability in glioblastoma using a brain-penetrant drug with a safe profile

1. Audrey Burban
2. Cloe Tessier
3. Mathieu Larroquette
4. Joris Guyon
5. Cloe Lubiato
6. Mathis Pinglaut
7. Maxime Toujas
8. Johanna Galvis
9. Benjamin Dartigues
10. Emmanuelle Georget
11. H Artee Luchman
12. Samuel Weiss
13. David Cappellen
14. Nathalie Nicot
15. Barbara Klink
16. Macha Nikolski
17. Lucie Brisson
18. Thomas Mathivet
19. Andreas Bikfalvi
20. Thomas Daubon
21. Ahmad Sharanek

Reviewed by Review Commons

Convergent epigenetic evolution drives relapse in acute myeloid leukemia

1. Kevin Nuno
2. Armon Azizi
3. Thomas Koehnke
4. Caleb Lareau
5. Asiri Ediriwickrema
6. M Ryan Corces
7. Ansuman T Satpathy
8. Ravindra Majeti

• Curated by eLife

  eLife assessment

  This important work substantially advances our understanding of how resistant leukemia can arise without changes in mutational patterns by displaying epigenetic changes. The evidence supporting the conclusions is compelling, with rigorous genomic assays done on primary samples. and state-of-the-art microscopy. The work will be of broad interest to hematologists and cancer biologists.

Reviewed by eLife

Role of HAO2 in rats with chronic kidney disease by regulating fatty acid metabolic processes in renal tissue

1. Xunjia Li
2. Chengxuan Liu
3. Aimin Yang
4. Youfeng Shen
5. Jian Xu
6. Deyu Zuo

Reviewed by PREreview

Chromosomal instability induced in cancer can enhance macrophage-initiated immune responses that include anti-tumor IgG

1. Brandon H Hayes
2. Mai Wang
3. Hui Zhu
4. Steven H Phan
5. Lawrence J Dooling
6. Jason C Andrechak
7. Alexander H Chang
8. Michael P Tobin
9. Nicholas M Ontko
10. Tristan Marchena
11. Dennis E Discher

• Curated by eLife

  eLife assessment

  The authors provide compelling evidence that MSP1 inhibition (leading to chromosomal instability or CIN in the cancer cells) increases phagocytosis and that tumors with CIN respond better to macrophage therapeutics. In this important study, they demonstrate particularly impressive survival rates for mouse models of CIN B16 tumors treated with adoptively transferred macrophages, CD47-SIRPα blockade, and anti-Tyrp1 IgG.

Reviewed by eLife

Cannabinoid combination targets NOTCH1-mutated T-cell acute lymphoblastic leukemia through the integrated stress response pathway

1. Elazar Besser
2. Anat Gelfand
3. Shiri Procaccia
4. Paula Berman
5. David Meiri

• Curated by eLife

  eLife assessment

  This important study follows up on previous work defining the anti-leukemic effects of a previously characterized cannabis extract on Notch-activated T cells and identifies several pathways that mediate its anti-cancer activity including the ER calcium and integrated stress response. The evidence is solid, but several concerns remain including the over reliance on a single cell line for the majority of the studies and lack of integration of the observations with existing literature

Reviewed by eLife

Exploration of drug resistance mechanisms in triple negative breast cancer cells using a microfluidic device and patient tissues

1. Wanyoung Lim
2. Inwoo Hwang
3. Jiande Zhang
4. Zhenzhong Chen
5. Jeonghun Han
6. Jaehyung Jeon
7. Bon-Kyoung Koo
8. Sangmin Kim
9. Jeong Eon Lee
10. Youngkwan Kim
11. Kenneth J Pienta
12. Sarah R Amend
13. Robert H Austin
14. Jee-Yin Ahn
15. Sungsu Park

• Curated by eLife

  eLife assessment

  This study based on the use of Cancer Drug Resistance Accelerator (CDRA) chip is valuable as a platform technology to assess chemoresistance mechanisms. The strength is convincing from the technological point of view. However, the use of a single cell line model is a limitation. However we acknowledge the authors' plan to further validate their current findings across multiple TNBC cell lines.

Reviewed by eLife

Mechanically stimulated osteocytes maintain tumor dormancy in bone metastasis of non-small cell lung cancer by releasing small extracellular vesicles

1. Jing Xie
2. Yafei Xu
3. Xuhua Liu
4. Li Long
5. Ji Chen
6. Chunyan Huang
7. Yan Shao
8. Zhiqing Cai
9. Zhimin Zhang
10. Ruixin Zhou
11. Jiarong Leng
12. Xiaochun Bai
13. Qiancheng Song

• Curated by eLife

  eLife assessment

  This is an important study, that adds to the field a new understanding of exercise or mechanical loading, microRNAs, and secreted extracellular vessicles in the field of lung cancer (NSCLC), which may have relevance to other osteolytic cancers. The strength of the evidence was mixed: whereas in vitro microRNA experiments were convincing, other elements were incomplete (e.g., proving the roles of osteocytes, as opposed to other mechanosensitive cells, in vivo). This work would be of broad interest to those investigating osteolytic cancers, and the role of exercise in bone cancer, preclinically.

Reviewed by eLife