Cancer Biology

Unravelling the metastasis-preventing effect of miR-200c in vitro and in vivo

1. Bianca Köhler
2. Emily Brieger
3. Tom Brandstätter
4. Elisa Hörterer
5. Ulrich Wilk
6. Jana Pöhmerer
7. Anna Jötten
8. Philipp Paulitschke
9. Chase P Broedersz
10. Stefan Zahler
11. Joachim O Rädler
12. Ernst Wagner
13. Andreas Roidl

Reviewed by Review Commons

Large pan-cancer cell screen coupled to (phospho-)proteomics underscores high-dose vitamin C as a potent anti-cancer agent

1. Andrea Vallés-Martí
2. Franziska Böttger
3. Elysia Yau
4. Khadija Tejjani
5. Loes Meijs
6. Sugandhi Sharma
7. Madiha Mumtaz
8. Tessa Y. S. Le Large
9. Ayse Erozenci
10. Daniëlle Dekker
11. Tim Schelfhorst
12. Jan Paul Medema
13. Irene V Bijnsdorp
14. Jaco C Knol
15. Sander R Piersma
16. Thang V. Pham
17. Elisa Giovannetti
18. Connie R Jiménez

• Curated by eLife

  eLife assessment

  This useful study utilizes proteomics analysis across a large panel of 51 cancer cell lines to elucidate mechanisms underlying the sensitivity of cancer cells to high-dose vitamin C (Ascorbate). While the associations between specific molecular pathways and sensitivity to ascorbate are interesting, a major limitation is that the study is largely descriptive and incomplete, lacking evidence on the molecular underpinnings of cancer cells' sensitivity to high-dose vitamin C.

Reviewed by eLife

Disassembly of embryonic keratin filaments promotes pancreatic cancer metastases

1. Ryan R. Kawalerski
2. Mariana Torrente Gonçalves
3. Chun-Hao Pan
4. Robert Tseng
5. Lucia Roa-Peña
6. Cindy V. Leiton
7. Luke A. Torre-Healy
8. Taryn Boyle
9. Sumedha Chowdhury
10. Natasha T. Snider
11. Kenneth R. Shroyer
12. Luisa F. Escobar-Hoyos

• Curated by eLife

  eLife assessment

  The authors address the function of keratin 17 (K17), a marker of the most aggressive pancreatic ductal adenocarcinomas (PDACs). While this potentially useful study addresses a significant area of pancreatic cancer research, the lack of evidence demonstrating nuclear localization of K17 in human PDAC and the excessive reliance on a single cell line reduce the significance of the work. Moreover, the weak phenotypes of K17 phosphosite mutants provide incomplete support for the authors' mechanistic model.

Reviewed by eLife