Cancer Biology

Long-term hematopoietic transfer of the anti-cancer and lifespan-extending capabilities of a genetically engineered blood system by transplantation of bone marrow mononuclear cells

1. Jing-Ping Wang
2. Chun-Hao Hung
3. Yae-Huei Liou
4. Ching-Chen Liu
5. Kun-Hai Yeh
6. Keh-Yang Wang
7. Zheng-Sheng Lai
8. Biswanath Chatterjee
9. Tzu-Chi Hsu
10. Tung-Liang Lee
11. Yu-Chiau Shyu
12. Pei-Wen Hsiao
13. Liuh-Yow Chen
14. Trees-Juen Chuang
15. Chen-Hsin Albert Yu
16. Nan-Shih Liao
17. C-K James Shen

• Curated by eLife

  eLife assessment

  This useful manuscript focuses on understanding how an Eklf mutation confers anticancer and longevity advantages in vivo. The data demonstrate that Eklf (K74R) imparts such advantages in a background and age independent manner in both female and male mice, and that the benefits are transferable by bone marrow transplantation. Despite added data since a previous version, the paper unfortunately remains incomplete, as it is still unclear whether Eklf affects resistance to malignant progression/metastasis by modulating Pd1 or Pdl1, or by increasing NK cells. The authors provide evidence that supports in principle both mechanisms, and they do not resolve which mechanism is primarily involved.

Reviewed by eLife

Integrative study of skeletal muscle mitochondrial dysfunction in a murine pancreatic cancer-induced cachexia model

1. Tristan Gicquel
2. Fabio Marchiano
3. Gabriela Reyes-Castellanos
4. Stephane Audebert
5. Luc Camoin
6. Bianca H Habermann
7. Benoit Giannesini
8. Alice Carrier

• Curated by eLife

  eLife assessment

  This useful study uses a mouse model of pancreatic cancer to examine mitochondrial mass and structure in atrophying muscle along with aspects of mitochondrial metabolism in the same tissue. Most relevant are the solid transcriptomics and proteomics approaches to map out related changes in gene expression networks in muscle during cancer cachexia.

Reviewed by eLife

N-cadherin dynamically regulates pediatric glioma cell migration in complex environments

1. Dayoung Kim
2. James M. Olson
3. Jonathan A. Cooper

Reviewed by Review Commons

GOT1 primes the cellular response to hypoxia by supporting glycolysis and HIF1α stabilisation

1. Fiona Grimm
2. Agustín Asuaje
3. Aakriti Jain
4. Mariana Silva dos Santos
5. Jens Kleinjung
6. Patrícia M. Nunes
7. Stefanie Gehrig
8. Louise Fets
9. James I. MacRae
10. Dimitrios Anastasiou

Reviewed by Review Commons

Bcl-xL is translocated to the nucleus via CtBP2 to epigenetically promote metastasis

1. Tiantian Zhang
2. Sha Li
3. Yingcai Adrian Tan
4. Xiang Chen
5. Cheryl Zhang
6. Zhengming Chen
7. Bikash Mishra
8. Joseph HyungJoon Na
9. Soyoung Choi
10. Sandra J. Shin
11. Priyadarshan Damle
12. Kranthi Kumar Chougoni
13. Steven R. Grossman
14. Dunrui Wang
15. Xuejun Jiang
16. Yi Li
17. Erika Hissong
18. Yao-Tseng Chen
19. Jenny Z. Xiang
20. Yi-Chieh Nancy Du

Reviewed by Review Commons

CDK12/CDK13 inhibition disrupts a transcriptional program critical for glioblastoma survival

1. Silje Lier
2. Solveig Osnes Lund
3. Anuja Lipsa
4. Katrin B. M. Frauenknecht
5. Idun Dale Rein
6. Preeti Jain
7. Anna Ulrika Lång
8. Emma Helena Lång
9. Niklas Meyer
10. Aparajita Dutta
11. Santosh Anand
12. Gaute Johan Nesse
13. Rune Forstrøm Johansen
14. Arne Klungland
15. Johanne Egge Rinholm
16. Stig Ove Bøe
17. Ashish Anand
18. Steven Michael Pollard
19. Simone P. Niclou
20. Mads Lerdrup
21. Deo Prakash Pandey

Reviewed by Review Commons

Ferredoxin 1 is essential for embryonic development and lipid homeostasis

1. Shakur Mohibi
2. Yanhong Zhang
3. Vivian Perng
4. Mingyi Chen
5. Jin Zhang
6. Xinbin Chen

• Curated by eLife

  eLife assessment

  The findings provided by Mohibi et al. are important to the field of lipid metabolism and cancer and provide insight for an in vivo role of FDX1. The evidence is solid, utilizing multiple modalities and both in vitro and in vivo lines of investigation.

Reviewed by eLife

GABRD promotes the progression of breast cancer through CDK1-dependent cell cycle regulation

1. Qingyao Shang
2. Fei Ren
3. Kexin Feng
4. Chenxuan Yang
5. Shuangtao Zhao
6. Jiaxiang Liu
7. Xiyu Kang
8. Jiaxian Yue
9. Ruixuan Zhang
10. Xiangzhi Meng
11. Xiang Wang
12. Xin Wang

• Curated by eLife

  eLife assessment

  This study presents a useful finding on the role of GABRD and its downstream target CDK1 in the progression of breast cancer. The evidence supporting the claims of the authors is somewhat incomplete and the elaboration of the mechanistic details on GABARD/CDK1 regulation would have strengthened the study. The work will be of interest to clinicians and biologists working on breast cancer.

Reviewed by eLife

A positive feedback loop between ZEB2 and ACSL4 regulates lipid metabolism to promote breast cancer metastasis

1. Jiamin Lin
2. Pingping Zhang
3. Wei Liu
4. Guorong Liu
5. Juan Zhang
6. Min Yan
7. Yuyou Duan
8. Na Yang

• Curated by eLife

  eLife assessment

  This study provides a valuable finding on the mechanistic connections between epithelial-mesenchymal transition (EMT) and lipid metabolism. The authors identified the ZEB2/ACSL4 axis as a newly discovered metastatic metabolic pathway that promotes both lipogenesis and fatty acid oxidation. The evidence supporting the claims of the authors is solid. The work will be of interest to medical biologists working on cancer.

Reviewed by eLife

Single-cell characterization of human GBM reveals regional differences in tumor-infiltrating leukocyte activation

1. Philip Schmassmann
2. Julien Roux
3. Steffen Dettling
4. Sabrina Hogan
5. Tala Shekarian
6. Tomás A Martins
7. Marie-Françoise Ritz
8. Sylvia Herter
9. Marina Bacac
10. Gregor Hutter

• Curated by eLife

  eLife assessment

  This study is valuable and contains results that are supported by convincing evidence. In the future, the observations could be further strengthened by independent validation, and by looking at larger numbers of patients, as well as by determining whether patient heterogeneity is either contributing to or obscuring certain patterns. The work will be of interest to a broad audience in the oncology and immunology fields as it is on a cancer type that does not respond well to immune checkpoint therapeutics.

Reviewed by eLife