Cancer Biology

CDK12/CDK13 inhibition disrupts a transcriptional program critical for glioblastoma survival

1. Silje Lier
2. Solveig Osnes Lund
3. Anuja Lipsa
4. Katrin B. M. Frauenknecht
5. Idun Dale Rein
6. Preeti Jain
7. Anna Ulrika Lång
8. Emma Helena Lång
9. Niklas Meyer
10. Aparajita Dutta
11. Santosh Anand
12. Gaute Johan Nesse
13. Rune Forstrøm Johansen
14. Arne Klungland
15. Johanne Egge Rinholm
16. Stig Ove Bøe
17. Ashish Anand
18. Steven Michael Pollard
19. Simone P. Niclou
20. Mads Lerdrup
21. Deo Prakash Pandey

Reviewed by Review Commons

Ferredoxin 1 is essential for embryonic development and lipid homeostasis

1. Shakur Mohibi
2. Yanhong Zhang
3. Vivian Perng
4. Mingyi Chen
5. Jin Zhang
6. Xinbin Chen

• Curated by eLife

  eLife assessment

  The findings provided by Mohibi et al. are important to the field of lipid metabolism and cancer and provide insight for an in vivo role of FDX1. The evidence is solid, utilizing multiple modalities and both in vitro and in vivo lines of investigation.

Reviewed by eLife

GABRD promotes the progression of breast cancer through CDK1-dependent cell cycle regulation

1. Qingyao Shang
2. Fei Ren
3. Kexin Feng
4. Chenxuan Yang
5. Shuangtao Zhao
6. Jiaxiang Liu
7. Xiyu Kang
8. Jiaxian Yue
9. Ruixuan Zhang
10. Xiangzhi Meng
11. Xiang Wang
12. Xin Wang

• Curated by eLife

  eLife assessment

  This study presents a useful finding on the role of GABRD and its downstream target CDK1 in the progression of breast cancer. The evidence supporting the claims of the authors is somewhat incomplete and the elaboration of the mechanistic details on GABARD/CDK1 regulation would have strengthened the study. The work will be of interest to clinicians and biologists working on breast cancer.

Reviewed by eLife

A positive feedback loop between ZEB2 and ACSL4 regulates lipid metabolism to promote breast cancer metastasis

1. Jiamin Lin
2. Pingping Zhang
3. Wei Liu
4. Guorong Liu
5. Juan Zhang
6. Min Yan
7. Yuyou Duan
8. Na Yang

• Curated by eLife

  eLife assessment

  This study provides a valuable finding on the mechanistic connections between epithelial-mesenchymal transition (EMT) and lipid metabolism. The authors identified the ZEB2/ACSL4 axis as a newly discovered metastatic metabolic pathway that promotes both lipogenesis and fatty acid oxidation. The evidence supporting the claims of the authors is solid. The work will be of interest to medical biologists working on cancer.

Reviewed by eLife

Single-cell characterization of human GBM reveals regional differences in tumor-infiltrating leukocyte activation

1. Philip Schmassmann
2. Julien Roux
3. Steffen Dettling
4. Sabrina Hogan
5. Tala Shekarian
6. Tomás A Martins
7. Marie-Françoise Ritz
8. Sylvia Herter
9. Marina Bacac
10. Gregor Hutter

• Curated by eLife

  eLife assessment

  This study is valuable and contains results that are supported by convincing evidence. In the future, the observations could be further strengthened by independent validation, and by looking at larger numbers of patients, as well as by determining whether patient heterogeneity is either contributing to or obscuring certain patterns. The work will be of interest to a broad audience in the oncology and immunology fields as it is on a cancer type that does not respond well to immune checkpoint therapeutics.

Reviewed by eLife

Cancer-associated fibroblasts promote drug resistance in ALK -driven lung adenocarcinoma cells by upregulating lipid biosynthesis

1. Ann-Kathrin Daum
2. Lisa Schlicker
3. Marc A. Schneider
4. Thomas Muley
5. Ursula Klingmüller
6. Almut Schulze
7. Michael Thomas
8. Petros Christopoulos
9. Holger Sültmann

Reviewed by Review Commons

NOTCH3 drives meningioma tumorigenesis and resistance to radiotherapy

1. Abrar Choudhury
2. Martha A. Cady
3. Calixto-Hope G. Lucas
4. Hinda Najem
5. Joanna J. Phillips
6. Brisa Palikuqi
7. Naomi Zakimi
8. Tara Joseph
9. Janeth Ochoa Birrueta
10. William C. Chen
11. Nancy Ann Oberheim Bush
12. Shawn L. Hervey-Jumper
13. Ophir D. Klein
14. Christine M. Toedebusch
15. Craig M. Horbinski
16. Stephen T. Magill
17. Aparna Bhaduri
18. Arie Perry
19. Peter J. Dickinson
20. Amy B. Heimberger
21. Alan Ashworth
22. Elizabeth E. Crouch
23. David R. Raleigh

Reviewed by PREreview

Disseminating cells in human oral tumours possess an EMT cancer stem cell marker profile that is predictive of metastasis in image-based machine learning

1. Gehad Youssef
2. Luke Gammon
3. Leah Ambler
4. Sophia Lunetto
5. Alice Scemama
6. Hannah Cottom
7. Kim Piper
8. Ian C Mackenzie
9. Michael P Philpott
10. Adrian Biddle

• Curated by eLife

  eLife assessment

  This is a valuable study that convincingly demonstrates that quantification of EpCAM+/CD24+/Vimentin+ cells in the stroma of human oral cancers followed by machine learning algorithms can be used as a prognostic indicator of metastasis.

Reviewed by eLife

Molecular portraits of colorectal cancer morphological regions

1. Eva Budinská
2. Martina Hrivňáková
3. Tina Catela Ivkovic
4. Marie Madrzyk
5. Rudolf Nenutil
6. Beatrix Bencsiková
7. Dagmar Al Tukmachi
8. Michaela Ručková
9. Lenka Zdražilová Dubská
10. Ondřej Slabý
11. Josef Feit
12. Mihnea-Paul Dragomir
13. Petra Borilova Linhartova
14. Sabine Tejpar
15. Vlad Popovici

• Curated by eLife

  eLife assessment

  This study presents a valuable finding on the putative molecular patterns underlying characteristic morphological regions observed in colorectal cancer (CRC). The authors provide a morphological framework through which clinicians might improve the performance of molecular signatures and consequently predict the clinical response of patients with better accuracy. The evidence supporting the claims of the authors is solid. The work will be of interest to clinicians and cancer biologists working in the field of CRC.

Reviewed by eLife

Post-EMT: Cadherin-11 mediates cancer hijacking fibroblasts

1. Weirong Kang
2. Yibo Fan
3. Yinxiao Du
4. Elina A. Tonkova
5. Yi-Hsin Hsu
6. Kel Vin Tan
7. Stephanie Alexander
8. Bin Sheng Wong
9. Haocheng Yang
10. Jingyuan Luo
11. Kuo Yao
12. Jiayao Yang
13. Xin Hu
14. Tingting Liu
15. Yu Gan
16. Jian Zhang
17. Jean J. Zhao
18. Konstantinos Konstantopoulos
19. Peter Friedl
20. Pek Lan Khong
21. Aiping Lu
22. Mien-Chie Hung
23. Michael B. Brenner
24. Jeffrey E. Segall
25. Zhizhan Gu

• Curated by eLife

  eLife assessment

  This paper presents a series of experiments investigating the role of cadherin-11 mediated interactions between cancer cells and fibroblasts in metastasis using updated 3D cell co-invasion assays. The primarily descriptive data are a valuable contribution to our understanding of the nature of cross cell-type interactions in metastasis, but are incomplete with respect to the far-reaching conclusions about the central role cadherin-11, especially given the complex nature of the phenotype and the need to better contextualize these observations in a complete picture of metastasis.

Reviewed by eLife