Cancer Biology

Integrin β4 promotes DNA damage-related drug resistance in triple-negative breast cancer via TNFAIP2/IQGAP1/RAC1

1. Huan Fang
2. Wenlong Ren
3. Qiuxia Cui
4. Huichun Liang
5. Chuanyu Yang
6. Wenjing Liu
7. Xinye Wang
8. Xue Liu
9. Yujie Shi
10. Jing Feng
11. Ceshi Chen

• Curated by eLife

  eLife assessment

  This study presents a rather valuable finding that IQGAP1 interacts with TNFAIP2, which activates Rac1 to promote drug resistance in TNBC. The evidence supporting the claims of the authors is quite solid. The work will be of interest to scientists working on breast cancer.

Reviewed by eLife

shRNA drop-out screen identifies BRD4 targeting transcription from RNA polymerase II system to activate β-catenin to promote soft-tissue tumor proliferations

1. Sylvia Y. Sun
2. Vlad Tsiperson

Reviewed by PREreview

Identification of CD133+ intercellsomes in intercellular communication to offset intracellular signal deficit

1. Kota Kaneko
2. Yan Liang
3. Qing Liu
4. Shuo Zhang
5. Alexander Scheiter
6. Dan Song
7. Gen-Sheng Feng

• Curated by eLife

  eLife assessment

  This important study was designed to examine the bypass of Ras/Erk signaling defects that enable limited regeneration in a mouse model of hepatic regeneration. This hepatocyte proliferation is associated with the expression by groups of cells of mRNA-loaded CD133+ intracellular vesicles that mediate an intercellular signaling pathway that supports proliferation. These are new observations, supported by convincing data, that have broad significance to the fields of regeneration and cancer.

Reviewed by eLife

Circulating tumor extracellular vesicles to monitor metastatic prostate cancer genomics and transcriptomic evolution

1. Irene Casanova-Salas
2. Sarai Cordoba-Terreros
3. Daniel Aguilar
4. Laura Agundez
5. Julian Brandariz
6. Nicolas Herranz
7. Macarena Gonzalez
8. Rafael Morales-Barrera
9. Alexandre Sierra
10. Mario Soriano-Navarro
11. Pablo Cresta
12. Sara Simonetti
13. Gonçalo Rodrigues
14. Sara Arce-Gallego
15. Luisa Delgado-Soriano
16. Irene Agustí
17. Elena Castellano-Sanz
18. Richard Mast
19. Matias de Albert
20. Ana Celma
21. Anna Santamaria
22. Lucila Gonzalez
23. Natalia Castro
24. Maria del Mar Suanes
25. Javier Hernández-Losa
26. Lara Nonell
27. Hector Peinado
28. Joan Carles
29. Joaquin Mateo

Reviewed by PREreview

Identifying targetable metabolic dependencies across colorectal cancer progression

1. Danny N. Legge
2. Ewelina Stanko
3. Amy K. Holt
4. Caroline J. Bull
5. Tracey J. Collard
6. Madhu Kollareddy
7. Jake Bellamy
8. Sarah Groves
9. Eric H. Ma
10. Emma Hazelwood
11. David Qualtrough
12. Borko Amulic
13. Karim Malik
14. Ann C. Williams
15. Nicholas Jones
16. Emma E. Vincent

Reviewed by Review Commons

Complementary CRISPR screen highlights the contrasting role of membrane-bound and soluble ICAM-1 in regulating antigen-specific tumor cell killing by cytotoxic T cells

1. Ann-Kathrin Herzfeldt
2. Marta Puig Gamez
3. Eva Martin
4. Lukasz Miloslaw Boryn
5. Praveen Baskaran
6. Heinrich J Huber
7. Michael Schuler
8. John E Park
9. Lee Kim Swee

• Curated by eLife

  eLife assessment

  This important research uses complementary CRISPR screening strategies to reveal novel pathways that prevent T cells from killing tumor cells. The evidence presented to support the claims is solid, although some additional assays defining the features of these novel pathways and their clinical relevance are still required. Overall, this work will be of broad interest to immunologists, cancer biologists, and those interested in cell adhesion and cell-cell communication.

Reviewed by eLife

A 3D microtumour system that faithfully represents ovarian cancer minimal residual disease

1. Xingyun Yang
2. Mara Artibani
3. Yongcheng Jin
4. Aneesh Aggarwal
5. Yujia Zhang
6. Sandra Muñoz-Galvan
7. Ellina Mikhailova
8. Lena Rai
9. Nobina Mukherjee
10. Ravinash Krishna Kumar
11. Ashwag Albukhari
12. Linna Zhou
13. Ahmed Ashour Ahmed
14. Hagan Bayley

Reviewed by PREreview

Small extracellular vesicles promote stiffness-mediated metastasis

1. Alexandra Sneider
2. Ying Liu
3. Bartholomew Starich
4. Wenxuan Du
5. Carolyn Marar
6. Najwa Faqih
7. Gabrielle E. Ciotti
8. Joo Ho Kim
9. Sejal Krishnan
10. Salma Ibrahim
11. Muna Igboko
12. Alexus Locke
13. Daniel M. Lewis
14. Hanna Hong
15. Michelle Karl
16. Raghav Vij
17. Gabriella C. Russo
18. Praful Nair
19. Estibaliz Gómez-de-Mariscal
20. Mehran Habibi
21. Arrate Muñoz-Barrutia
22. Luo Gu
23. T.S. Karin Eisinger-Mathason
24. Denis Wirtz

Reviewed by preLights

The BRD4S-LOXL2-MED1 interaction at the forefront of cell cycle transcriptional control in triple-negative breast cancer

1. Laura Pascual-Reguant
2. Tian V. Tian
3. Debayan Datta
4. Damiano Cianferoni
5. Savvas Kourtis
6. Antoni Gañez-Zapater
7. Chiara Cannatá
8. Queralt Serra-Camprubi
9. Lorena Espinar
10. Maria Guirola
11. Jessica Querol
12. Andrea Miró Canturri
13. Joaquin Arribas
14. Luis Serrano
15. Sandra Peiró
16. Sara Sdelci

Reviewed by Review Commons

Major data analysis errors invalidate cancer microbiome findings

1. Abraham Gihawi
2. Yuchen Ge
3. Jennifer Lu
4. Daniela Puiu
5. Amanda Xu
6. Colin S. Cooper
7. Daniel S. Brewer
8. Mihaela Pertea
9. Steven L. Salzberg

Reviewed by Arcadia Science