Cancer Biology

RGS10 deficiency facilitates distant metastasis by inducing epithelial–mesenchymal transition in breast cancer

1. Yang Liu
2. Yi Jiang
3. Peng Qiu
4. Tie Ma
5. Yang Bai
6. Jiawen Bu
7. Yueting Hu
8. Ming Jin
9. Tong Zhu
10. Xi Gu

• Curated by eLife

  eLife assessment

  This valuable paper first demonstrated that RGS10 was identified as a biomarker to evaluate the prognosis of breast cancer. To prevent the loss of RGS10 theoretically provide a new strategy for the treatment of breast cancer. The evidence supporting the claims of the authors is solid, although inclusion of a larger number of patient samples and an animal model would have strengthened the study. The work will be of interest to clinicians working on breast cancer.

Reviewed by eLife

Comparison of Tug-of-War Models Assuming Moran versus Branching Process Population Dynamics

1. Khanh N. Dinh
2. Monika K. Kurpas
3. Marek Kimmel

• Curated by eLife

  eLife assessment

  This study uses numerical simulations to characterize and compare variants of two widely used mathematical models and then applies those models to inferring evolutionary parameters from breast cancer data. The copious numerical results will be of some interest to mathematical biologists working with similar models. The finding that many breast cancer mutations are mildly deleterious is valuable but the evidence supporting this claim is incomplete because the mathematical modelling and statistical methods are insufficiently justified and inadequately validated.

Reviewed by eLife

STIL overexpression shortens lifespan and reduces tumor formation in mice

1. Amira-Talaat Moussa
2. Marco R. Cosenza
3. Timothy Wohlfromm
4. Katharina Brobeil
5. Anthony Hill
6. Annarita Patrizi
7. Karin Müller-Decker
8. Tim Holland-Letz
9. Anna Jauch
10. Bianca Kraft
11. Alwin Krämer

Reviewed by Review Commons

Identification of a Musashi2 translocation as a novel oncogene in myeloid leukemia

1. Kyle Spinler
2. Michael Hamilton
3. Jeevisha Bajaj
4. Yutaka Shima
5. Emily Diaz
6. Marcie Kritzik
7. Tannishtha Reya

• Curated by eLife

  eLife assessment

  The study presents important findings on the role of MSI2-HOXA9 translocation in chronic myeloid leukemia. The authors provide convincing evidence supporting the role of this translocation in leukemogenesis by using elegant mouse modeling and in vitro mechanistic studies. Consistent with the reviews, the studies can be strengthened with further murine and cell line experiments.

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RAPSYN-mediated neddylation of BCR-ABL alternatively determines the fate of Philadelphia chromosome-positive leukemia

1. Mengya Zhao
2. Beiying Dai
3. Xiaodong Li
4. Yixin Zhang
5. Chun Qiao
6. Yaru Qin
7. Zhao Li
8. Qingmei Li
9. Shuzhen Wang
10. Yong Yang
11. Yijun Chen

• Curated by eLife

  eLife assessment

  In this important study, the authors describe a novel function for RAPSYN in bcr-abl fusion associated leukemia, presenting convincing evidence that RAPSYN stabilizes the oncogenic BCR-ABL fusion protein. Compared to an earlier version of the manuscript, the authors have added data using primary samples that strengthen the conclusions.

Reviewed by eLife

Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability

1. Keene L Abbott
2. Ahmed Ali
3. Bradley I Reinfeld
4. Amy Deik
5. Sonu Subudhi
6. Madelyn D Landis
7. Rachel A Hongo
8. Kirsten L Young
9. Tenzin Kunchok
10. Christopher S Nabel
11. Kayla D Crowder
12. Johnathan R Kent
13. Maria Lucia L Madariaga
14. Rakesh K Jain
15. Kathryn E Beckermann
16. Caroline A Lewis
17. Clary B Clish
18. Alexander Muir
19. W Kimryn Rathmell
20. Jeffrey Rathmell
21. Matthew G Vander Heiden

• Curated by eLife

  eLife assessment

  This study provides an important finding that the local abundance of metabolites impacts the biology of the tumor microenvironment by utilizing kidney tumors from patients and adjacent normal tissues. The evidence supporting the claims of the authors is convincing. The work will of interest to the research community working on metabolism and kidney cancer especially.

Reviewed by eLife

mTORC1/S6K1 signaling promotes sustained oncogenic translation through modulating CRL3IBTK-mediated ubiquitination of eIF4A1 in cancer cells

1. Dongyue Jiao
2. Huiru Sun
3. Xiaying Zhao
4. Yingji Chen
5. Zeheng Lv
6. Qing Shi
7. Yao Li
8. Chenji Wang
9. Kun Gao

• Curated by eLife

  eLife assessment

  This study reports a novel substrate and a mediator of oncogenesis downstream of mTORC1, a fundamental advance in our understanding of the mechanistic basis of mTORC1-regulated cap-dependent translation and protein synthesis. Using an array of biochemical, proteomic and functional assays, the authors provide compelling evidence for a novel mTORC1/S6K1-IBTK-eIF4A1 signaling axis that promotes cancer pathogenic translation. This work is of broad interest and significance, given the importance of aberrant protein synthesis in cancer.

Reviewed by eLife

Internalisation of integrin-bound extracellular matrix modulates invasive carcinoma cell migration

1. Montserrat Llanses Martinez
2. Keqian Nan
3. Zhe Bao
4. Rachele Bacchetti
5. Shengnan Yuan
6. Joe Tyler
7. Xavier Le Guezennec
8. Frédéric A. Bard
9. Elena Rainero

Reviewed by Review Commons

Pharmacologic inhibition of BAF chromatin remodeling complexes as a therapeutic approach to transcription factor-dependent cancers

1. Richard C. Centore
2. Luis M. M. Soares
3. Salih Topal
4. Rishi G. Vaswani
5. Kana Ichikawa
6. Zhifang Li
7. Hong Fan
8. Jeremy W. Setser
9. David L. Lahr
10. Laura E. Zawadzke
11. Xueying Chen
12. Kimberly D. Barnash
13. Jordana Muwanguzi
14. Neville Anthony
15. Gabriel J. Sandoval
16. Katharine Feldman
17. GiNell Elliott
18. Ammar Adam
19. David Huang
20. Yunji Davenport
21. Shawn Schiller
22. Kevin J. Wilson
23. Johannes Voigt
24. Lan Xu
25. Martin Hentemann
26. David S. Millan
27. Ho Man Chan
28. Carl P. Decicco
29. Ryan G. Kruger
30. Steven F. Bellon

• Curated by eLife

  eLife assessment

  This work substantially advances our understanding of pharmacological inhibition of SWI/SNF as a therapeutic approach for cancer. The study is well-written and provides compelling evidence, including comprehensive datasets, compound screens, gene expression analysis, epigenetics, as well as animal studies. This study provides a fundamental advance for the uveal melanoma research field that might be exploited to target this deadly cancer and more generally for targeting transcriptional dependency in cancers.

Reviewed by eLife

Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition

1. Gregory Caleb Howard
2. Jing Wang
3. Kristie L Rose
4. Camden Jones
5. Purvi Patel
6. Tina Tsui
7. Andrea C Florian
8. Logan Vlach
9. Shelly L Lorey
10. Brian C Grieb
11. Brianna N Smith
12. Macey J Slota
13. Elizabeth M Reynolds
14. Soumita Goswami
15. Michael R Savona
16. Frank M Mason
17. Taekyu Lee
18. Stephen Fesik
19. Qi Liu
20. William P Tansey

• Curated by eLife

  eLife assessment

  This important paper reveals that one of the major roles of the WDR5 WIN site is to promote ribosome synthesis, and that by attacking the WIN site with inhibitors ribosome attrition occurs creating new vulnerabilities that can be therapeutically exploited. This deficiency of ribosomal proteins also provokes the p53 response. The data from a variety of approaches is generally very convincing, and together buttresses the authors' conclusions and interpretations quite nicely; overall, this paper will provide a justification for pre-clinical and translational studies of WDR5 interaction site inhibitors.

Reviewed by eLife