Cancer Biology

Dual targeting of histone deacetylases and MYC as potential treatment strategy for H3-K27M pediatric gliomas

1. Danielle Algranati
2. Roni Oren
3. Bareket Dassa
4. Liat Fellus-Alyagor
5. Alexander Plotnikov
6. Haim Barr
7. Alon Harmelin
8. Nir London
9. Guy Ron
10. Noa Furth
11. Efrat Shema

• Curated by eLife

  eLife assessment

  This work contributes to the study of H3-K27M mutated pediatric gliomas. It convincingly demonstrates that the concomitant targeting of histone deacetylases (HDACs) and the transcription factor MYC results in a notable reduction in cell viability and tumor growth. This reduction is linked to the suppression of critical oncogenic pathways, particularly mTOR signaling, emphasizing the role of these pathways in the disease's pathogenesis. The current version of the manuscript is important because it unveils a vulnerability from dual targeting HDACs and MYC in the context of pediatric gliomas. This work will be of interest to cancer epigenetics and therapeutics research, with a focus on the neuro-oncology field.

Reviewed by eLife

Timing of treatment shapes the path to androgen receptor signaling inhibitor resistance in prostate cancer

1. Eugine Lee
2. Zeda Zhang
3. Chi-Chao Chen
4. Danielle Choi
5. Aura C. Agudelo Rivera
6. Eliot Linton
7. Yu-jui Ho
8. Jillian Love
9. Justin LaClair
10. John Wongvipat
11. Charles L. Sawyers

• Curated by eLife

  eLife assessment

  This important study provides new insight into the dynamics that underlie the development of therapy resistance in prostate cancer by revealing that divergent tumor evolutionary paths occur in response to different treatment timing and that these converge on common resistance mechanisms. The use of barcoded lineage tracing and characterization of isolated tumor clonal populations provides compelling evidence supporting the importance of clonal dynamics in a tumor ecosystem for treatment resistance. Several open questions remain, however, raising the possibility of alternative interpretations of the data set in its current form. Overall, the findings deepen our understanding of prostate cancer evolution and hold promising implications for how drug resistance can be addressed or prevented.

Reviewed by eLife

Netrin signaling mediates survival of dormant epithelial ovarian cancer cells

1. Pirunthan Perampalam
2. James I MacDonald
3. Komila Zakirova
4. Daniel T Passos
5. Sumaiyah Wasif
6. Yudith Ramos-Valdes
7. Maeva Hervieu
8. Patrick Mehlen
9. Rob Rottapel
10. Benjamin Gibert
11. Rohann JM Correa
12. Trevor G Shepherd
13. Frederick A Dick

• Curated by eLife

  eLife assessment

  The authors further corroborated their model that Netrin signaling promotes survival and dissemination of non-proliferating ovarian cancer cells. These valuable results were found to be of significant potential interest to cancer biologists in as much as they address gaps in knowledge pertinent to the mechanisms underpinning ovarian cancer spread. In general, it was thought that solid experimental evidence was provided to support the role of Netrin signaling in fueling ovarian cancer progression.

Reviewed by eLife

Elevated FOXG1 supports exit from quiescence in neural stem cells through FoxO6

1. Kirsty M Ferguson
2. Carla Blin
3. Claudia Garcia-Diaz
4. Harry Bulstrode
5. Raul Bardini Bressan
6. Katrina McCarten
7. Steven M. Pollard

Reviewed by Review Commons

Tissue-resident natural killer cells support survival in pancreatic cancer through promotion of cDC1-CD8 T activity

1. Simei Go
2. Constantinos Demetriou
3. Giampiero Valenzano
4. Sophie Hughes
5. Simone Lanfredini
6. Helen Ferry
7. Edward Arbe-Barnes
8. Shivan Sivakumar
9. Rachel Bashford-Rogers
10. Mark R Middleton
11. Somnath Mukherjee
12. Jennifer Morton
13. Keaton Jones
14. Eric O Neill

• Curated by eLife

  eLife assessment

  This valuable manuscript provides an interesting account documenting the role of resident CD56(br) NK cells in driving interaction with dendritic cells that attract CD8+ T cells to the pancreas cancer tumor microenvironment (TME). The work convincingly illustrates how irradiation combined with CCR5i and PD1 blockade leads to a reduction in pancreatic cancer growth that correlates with a reduction in Treg cells and enhancement of NK and CD8 T cells in the TME. The correlation of NKC1 signature with survival in pancreatic cancer patients is indeed of broader interest regarding potential relevance to other types of cancer.

Reviewed by eLife

A syngeneic spontaneous zebrafish model of tp53-deficient, EGFRvIII, and PI3KCAH1047R-driven glioblastoma reveals inhibitory roles for inflammation during tumor initiation and relapse in vivo

1. Alex Weiss
2. Cassandra D'Amata
3. Bret J Pearson
4. Madeline N Hayes

• Curated by eLife

  eLife assessment

  This study presents a valuable syngeneic zebrafish model for studying glioblastoma and will be of interest to neuro-oncologists and cancer biologists. Using a feasible in vivo model to study the tumour microenvironment, cell/cell interaction, and immunity, the data are compelling, and opens up new lines of inquiries for future investigation on the impact of efferocytosis on tumor progression and cell of origin in this model as well as assessments of drug resistance mechanisms, using inhibitors to MAPK , Akt and/or mTOR pathway.

Reviewed by eLife

RBM7 deficiency promotes breast cancer metastasis by coordinating MFGE8 splicing switch and NF-kB pathway

1. Fang Huang
2. Zhenwei Dai
3. Jinmiao Yu
4. Kainan Wang
5. Chaoqun Chen
6. Dan Chen
7. Jinrui Zhang
8. Jinyao Zhao
9. Mei Li
10. Wenjing Zhang
11. Xiaojie Li
12. Yangfan Qi
13. Yang Wang

• Curated by eLife

  eLife assessment

  This study presents a rather valuable finding on the RBM7 function in spicing regulation and uncharacterized role of MFGE8 splicing alteration in breast cancer metastasis. The evidence supporting the claims of the authors is solid. The work will be of broad interest to clinicians, medical researchers and scientists working on breast cancer.

Reviewed by eLife

Prognostic Significance of preoperative serum CA125, CA19-9, CA72-4, CEA, and AFP in Patients with Endometrial cancer

1. Zi-hao Wang
2. Yun-zheng Zhang
3. Shu-wen Ge
4. Luhe-Shan
5. Bo Wang
6. Zi-yu Zhang
7. Qi-jun Wu
8. Xiao-xin Ma

• Curated by eLife

  eLife assessment

  This study presents a valuable finding on prognostic values of serum CA125, CEA, and AFP for predicting patient outcomes of endometrial cancer. The evidence supporting the claims of the authors is solid, although inclusion of detailed discussion of present results with prior documented findings would have strengthened the study. The work will be of interest to scientists working on endometrial cancer.

Reviewed by eLife

Emerging role of oncogenic ß-catenin in exosome biogenesis as a driver of immune escape in hepatocellular carcinoma

1. Camille Dantzer
2. Justine Vaché
3. Aude Brunel
4. Isabelle Mahouche
5. Anne-Aurélie Raymond
6. Jean-William Dupuy
7. Melina Petrel
8. Paulette Bioulac-Sage
9. David Perrais
10. Nathalie Dugot-Senant
11. Mireille Verdier
12. Barbara Bessette
13. Clotilde Billottet
14. Violaine Moreau

• Curated by eLife

  eLife assessment

  Hepatocellular carcinoma (HCC) is a particularly aggressive form of cancer, with an increasing number of treatment options approved for use in patients over the past decade. However, the biology of HCC and identifiable therapeutic targets have not been as clear, even in the era of molecular oncology. Likewise, the cellular biology of HCC, including the role of intercellular communication, has not been well elucidated. In this compelling study, Dantzer et al. provide fundamental insight into the role of beta-catenin on intercellular communication occurring via extracellular vesicles, with implications for immune evasion in a cancer increasingly being treated using immuno-oncologic agents.

Reviewed by eLife

Post-transcriptional control drives Aurora kinase A expression in human cancers

1. Roberta Cacioppo
2. Deniz Rad
3. Giulia Pagani
4. Paolo Gandellini
5. Catherine Lindon

Reviewed by Review Commons