Cancer Biology

Engineering ERα degraders with pleiotropic ubiquitin ligase ligands maximizes therapeutic efficacy by co-opting distinct effector ligases

1. Anna Shemorry
2. Willem den Besten
3. Melinda M. Mulvihill
4. Curt J. Essenburg
5. Nicole Blaquiere
6. Tracy Kleinheinz
7. Elisia Villemure
8. Frank Peale
9. Gauri Deshmukh
10. Danilo Maddalo
11. Elizabeth Levy
12. Kebing Yu
13. Matthew R. Steensma
14. Elizabeth A. Tovar
15. Emily Wolfrum
16. Karthik Nagapudi
17. Robert A. Blake
18. William F. Forrest
19. Steven T. Staben
20. Carrie R. Graveel
21. Wayne J. Fairbrother
22. Ingrid E. Wertz

Reviewed by PREreview

Telomere length sensitive regulation of interleukin receptor 1 type 1 (IL1R1) by the shelterin protein TRF2 modulates immune signalling in the tumour microenvironment

1. Ananda Kishore Mukherjee
2. Subhajit Dutta
3. Ankita Singh
4. Shalu Sharma
5. Shuvra Shekhar Roy
6. Antara Sengupta
7. Megha Chatterjee
8. Soujanya Vinayagamurthy
9. Sulochana Bagri
10. Divya Khanna
11. Meenakshi Verma
12. Dristhi Soni
13. Anshul Budharaja
14. Sagar Kailasrao Bhisade
15. Vivek Anand
16. Ahmad Perwez
17. Nija George
18. Mohammed Faruq
19. Ishaan Gupta
20. Radhakrishnan Sabarinathan
21. Shantanu Chowdhury

• Curated by eLife

  eLife Assessment

  This study presents an important finding on the role of telomeres in modulating interleukin-1 signaling and tumor immunity in TNBC. The evidence supporting these findings is solid, presented through comprehensive analyses including TNBC clinical samples, tumor-derived organoids, cancer cells, and xenografts. The work will be of broad interest to cell and medical biologists focusing on TNBC.

Reviewed by eLife

SNAI2 cooperates with MEK1/2 and HDACs to suppress BIM- and BMF-dependent apoptosis in TERT promoter mutant cancers

1. Amol Tandon
2. Josh Stern

Reviewed by PREreview

Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell properties

1. Jae Hun Shin
2. Jooyoung Park
3. Jaechul Lim
4. Jaekwang Jeong
5. Ravi K Dinesh
6. Stephen E Maher
7. Jeonghyun Kim
8. Soyeon Park
9. Jun Young Hong
10. John Wysolmerski
11. Jungmin Choi
12. Alfred LM Bothwell

• Curated by eLife

  eLife Assessment

  This valuable study proposes that protein secreted by colon cancer cells induces cells with Paneth-like properties that favor colon cancer metastasis. The evidence supporting the conclusions is strong but would benefit from more direct experiments to test the functional role of Paneth-like cells and to monitor metastasis from colon tumors. The work will be of interest to researchers studying colon cancer metastasis.

Reviewed by eLife

An integrin centered complex coordinates ion transport and pH to regulate f-actin organization and cell migration in breast cancer

1. Chiara Capitani
2. Jessica Iorio
3. Elena Lastraioli
4. Claudia Duranti
5. Giacomo Bagni
6. Ginevra Chioccioli Altadonna
7. Rossella Colasurdo
8. Giorgia Scarpellino
9. Scott P. Fraser
10. Andrea Becchetti
11. Mustafa B. A. Djamgoz
12. Annarosa Arcangeli

• Curated by eLife

  eLife Assessment

  This study presents a valuable finding on the identification of a complex consisting of NHE1, hERG1, β1/integrin and NaV1.5 on the membrane of breast cancer cells. The evidence supporting the claims of the authors is somewhat incomplete. The inclusion of clarification of some experimental design and the amendment of cropping Western blot data would have strengthened the study. The work will be of interest to scientists working on breast cancer.

Reviewed by eLife

Charting the liver and lung metastatic niche in breast cancer

1. Magdalena K. Sznurkowska
2. Francesc Castro-Giner
3. Ilona Krol
4. Yongzhan Zhang
5. Lauren L. Ozimski
6. Irene D’Anna
7. Alexander Ring
8. Fabienne Dominique Schwab
9. Yu Wei Zhang
10. Jianwen Zhou
11. Massimo Saini
12. Karin Strittmatter
13. Selina Budinjas
14. Marko Vujanovic
15. Zacharias Kontarakis
16. Giada Pontecorvi
17. Francesca Albrecht
18. Kirsten D. Mertz
19. Gaël Auray
20. Claudio Giachino
21. Verdon Taylor
22. Ana Gvozdenovic
23. Werner J. Kovacs
24. Ilaria Malanchi
25. Heike Frauchiger-Heuer
26. Andreas Wicki
27. Marcus Vetter
28. Matteo Ligorio
29. Nicola Aceto

Reviewed by Life Science Editors Foundation

A Novel HER2 Protein Identification Methodology in Breast Cancer Cells Using Raman Spectroscopy and Raman Imaging: An Analytical Validation Study

1. Halina Abramczyk
2. Jakub Maciej Surmacki
3. Monika Kopeć

Reviewed by Arcadia Science

Bestrophin-4 relays HES4 and interacts with TWIST1 to suppress epithelial-to-mesenchymal transition in colorectal cancer cells

1. Zijing Wang
2. Bihan Xia
3. Shaochong Qi
4. Xian Zhang
5. Xiaoshuang Zhang
6. Yan Li
7. Huimin Wang
8. Miao Zhang
9. Ziyi Zhao
10. David Kerr
11. Li Yang
12. Shijie Cai
13. Jilin Yang

• Curated by eLife

  eLife Assessment

  The findings of this valuable manuscript advance our understanding of the significance of Bestrophin isoform 4 (BEST4) in suppressing colorectal cancer (CRC) progression. The authors used appropriate and validated methodology, such as the knockout of BEST4 using CRISPR/Cas9 in CRC cells, to provide a solid foundation for elucidating the potential link between BEST4 and CRC progression.

Reviewed by eLife

High-density sampling reveals volume growth in human tumours

1. Arman Angaji
2. Michel Owusu
3. Christoph Velling
4. Nicola Dick
5. Donate Weghorn
6. Johannes Berg

• Curated by eLife

  eLife Assessment

  The article uses a cell-based model to investigate how mutations and cells spread throughout a tumour. The paper uses published data and the proposed model to understand how growth and death mechanisms lead to the observed data. This work provides an important insight into the early stages of tumour development. From the work provided here, the results are convincing, using a thorough analysis.

Reviewed by eLife

Restraint of melanoma progression by cells in the local skin environment

1. Yilun Ma
2. Mohita Tagore
3. Miranda V Hunter
4. Ting-Hsiang Huang
5. Emily Montal
6. Joshua M Weiss
7. Richard M White

• Curated by eLife

  eLife Assessment

  In this important study, the authors used a zebrafish model and scRNAseq analysis to show that a subset of keratinocytes within melanoma microenvironment highly up-regulate Twist and undergo Epithelial-Mesenchymal Transition (EMT). Surprisingly, when overexpressing Twist in keratinocytes, the resulting alteration in keratinocytes is inhibitory for melanoma invasion in both zebrafish and human cell culture models. The results are supported by overall convincing experimental data that provide new insights into the interactions between melanoma cells and their environment.

Reviewed by eLife