Cancer Biology

Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation

1. Trang H. Pham
2. Kanika Bajaj Pahuja
3. Thijs J. Hagenbeek
4. Jason Zbieg
5. Cameron L. Noland
6. Victoria C. Pham
7. Xiaosai Yao
8. Christopher M. Rose
9. Kristen C. Browder
10. Ho-June Lee
11. Mamie Yu
12. May Liang-Chu
13. Scott Martin
14. Erik Verschueren
15. Jason Li
16. Marta H. Kubala
17. Rina Fong
18. Maria Lorenzo
19. Paul Beroza
20. Peter Hsu
21. Sayantanee Paul
22. Elisia Villemure
23. Wendy Lee
24. Tommy K. Cheung
25. Saundra Clausen
26. Jennifer Lacap
27. Yuxin Liang
28. Jason Cheng
29. Steve Schmidt
30. Zora Modrusan
31. Michael Cohen
32. James Crawford
33. Heinrich Jasper
34. Alan Ashworth
35. Jennie R. Lill
36. Shiva Malek
37. Joachim Rudolph
38. Ingrid E. Wertz
39. Matthew T. Chang
40. Xin Ye
41. Anwesha Dey

• Curated by eLife

  eLife assessment

  This important and comprehensive study describes the development of a heterobifunctional degrader, which is used to provide insights into the mechanism of TEAD proteolysis, with potential implications for signaling pathways in cancer. While the methods are solid, the analyses and descriptions are still incomplete. With further molecular refinements, experimental controls, and a more cohesive and unified story, this article will be of interest to cancer biologists and scientists interested in proteostasis, cellular signaling, and post-translation modification of proteins.

Reviewed by eLife

Long-term hematopoietic transfer of the anti-cancer and lifespan-extending capabilities of a genetically engineered blood system by transplantation of bone marrow mononuclear cells

1. Jing-Ping Wang
2. Chun-Hao Hung
3. Yae-Huei Liou
4. Ching-Chen Liu
5. Kun-Hai Yeh
6. Keh-Yang Wang
7. Zheng-Sheng Lai
8. Biswanath Chatterjee
9. Tzu-Chi Hsu
10. Tung-Liang Lee
11. Yu-Chiau Shyu
12. Pei-Wen Hsiao
13. Liuh-Yow Chen
14. Trees-Juen Chuang
15. Chen-Hsin Albert Yu
16. Nan-Shih Liao
17. C-K James Shen

• Curated by eLife

  eLife assessment

  This useful manuscript focuses on understanding how an Eklf mutation confers anticancer and longevity advantages in vivo. The data demonstrate that Eklf (K74R) imparts such advantages in a background and age independent manner in both female and male mice, and that the benefits are transferable by bone marrow transplantation. Despite added data since a previous version, the paper unfortunately remains incomplete, as it is still unclear whether Eklf affects resistance to malignant progression/metastasis by modulating Pd1 or Pdl1, or by increasing NK cells. The authors provide evidence that supports in principle both mechanisms, and they do not resolve which mechanism is primarily involved.

Reviewed by eLife

Integrative study of skeletal muscle mitochondrial dysfunction in a murine pancreatic cancer-induced cachexia model

1. Tristan Gicquel
2. Fabio Marchiano
3. Gabriela Reyes-Castellanos
4. Stephane Audebert
5. Luc Camoin
6. Bianca H Habermann
7. Benoit Giannesini
8. Alice Carrier

• Curated by eLife

  eLife assessment

  This useful study uses a mouse model of pancreatic cancer to examine mitochondrial mass and structure in atrophying muscle along with aspects of mitochondrial metabolism in the same tissue. Most relevant are the solid transcriptomics and proteomics approaches to map out related changes in gene expression networks in muscle during cancer cachexia.

Reviewed by eLife

FORMATION OF MALIGNANT, METASTATIC SMALL CELL LUNG CANCERS THROUGH OVERPRODUCTION OF cMYC PROTEIN IN TP53 AND RB1 DEPLETED PULMONARY NEUROENDOCRINE CELLS DERIVED FROM HUMAN EMBRYONIC STEM CELLS

1. HuanHuan (Joyce) Chen
2. Eric Edison Gardner
3. Yajas Shah
4. Kui Zhang
5. Abhimanyu Thakur
6. Chen Zhang
7. Olivier Elemento
8. Harold Varmus

• Curated by eLife

  eLife assessment

  Given a great need for novel human model systems to study small cell lung cancer (SCLC), the authors describe an important pre-clinical model with broad potential for the study of how genetic perturbations or drug treatments alter SCLC tumor growth, metastasis, and response to therapy. For the major finding, the authors provide convincing evidence that RB/TP53 suppression coupled with MYC overexpression in an ES cell-derived model system results in aggressive and metastatic SCLC. However, comparisons of the RB/TP53-suppressed, MYC overexpressing model with RB/TP53-suppressed cells in supporting the minor conclusion that MYC overexpression increases the neuroendocrine compartment are incomplete, and the impact of the work would have been increased with the inclusion of a broader set of genetic perturbations, such as over-expression of MYCL, to better model major SCLC phenotypes. The new model described will be of significant interest to researchers studying lung cancer.

Reviewed by eLife

N-cadherin dynamically regulates pediatric glioma cell migration in complex environments

1. Dayoung Kim
2. James M Olson
3. Jonathan A Cooper

Reviewed by Review Commons

GOT1 primes the cellular response to hypoxia by supporting glycolysis and HIF1α stabilisation

1. Fiona Grimm
2. Agustín Asuaje
3. Aakriti Jain
4. Mariana Silva dos Santos
5. Jens Kleinjung
6. Patrícia M. Nunes
7. Stefanie Gehrig
8. Louise Fets
9. James I. MacRae
10. Dimitrios Anastasiou

Reviewed by Review Commons

Bcl-xL is translocated to the nucleus via CtBP2 to epigenetically promote metastasis

1. Tiantian Zhang
2. Sha Li
3. Yingcai Adrian Tan
4. Joseph HyungJoon Na
5. Zhengming Chen
6. Priyadarshan Damle
7. Xiang Chen
8. Soyoung Choi
9. Bikash Mishra
10. Dunrui Wang
11. Steven R. Grossman
12. Xuejun Jiang
13. Yi Li
14. Yao-Tseng Chen
15. Jenny Z. Xiang
16. Yi-Chieh Nancy Du

Reviewed by Review Commons

CDK12/CDK13 inhibition disrupts a transcriptional program critical for glioblastoma survival

1. Silje Lier
2. Solveig Osnes Lund
3. Anuja Lipsa
4. Katrin B. M. Frauenknecht
5. Idun Dale Rein
6. Preeti Jain
7. Anna Ulrika Lång
8. Emma Helena Lång
9. Niklas Meyer
10. Aparajita Dutta
11. Santosh Anand
12. Gaute Johan Nesse
13. Rune Forstrøm Johansen
14. Arne Klungland
15. Johanne Egge Rinholm
16. Stig Ove Bøe
17. Ashish Anand
18. Steven Michael Pollard
19. Simone P. Niclou
20. Mads Lerdrup
21. Deo Prakash Pandey

Reviewed by Review Commons

Ferredoxin 1 is essential for embryonic development and lipid homeostasis

1. Shakur Mohibi
2. Yanhong Zhang
3. Vivian Perng
4. Mingyi Chen
5. Jin Zhang
6. Xinbin Chen

• Curated by eLife

  eLife assessment

  The findings provided by Mohibi et al. are important to the field of lipid metabolism and cancer and provide insight for an in vivo role of FDX1. The evidence is solid, utilizing multiple modalities and both in vitro and in vivo lines of investigation.

Reviewed by eLife

GABRD promotes the progression of breast cancer through CDK1-dependent cell cycle regulation

1. Qingyao Shang
2. Fei Ren
3. Kexin Feng
4. Chenxuan Yang
5. Shuangtao Zhao
6. Jiaxiang Liu
7. Xiyu Kang
8. Jiaxian Yue
9. Ruixuan Zhang
10. Xiangzhi Meng
11. Xiang Wang
12. Xin Wang

• Curated by eLife

  eLife assessment

  This study presents a useful finding on the role of GABRD and its downstream target CDK1 in the progression of breast cancer. The evidence supporting the claims of the authors is somewhat incomplete and the elaboration of the mechanistic details on GABARD/CDK1 regulation would have strengthened the study. The work will be of interest to clinicians and biologists working on breast cancer.

Reviewed by eLife