Cancer Biology

Charting the liver and lung metastatic niche in breast cancer

1. Magdalena K. Sznurkowska
2. Francesc Castro-Giner
3. Ilona Krol
4. Yongzhan Zhang
5. Lauren L. Ozimski
6. Irene D’Anna
7. Alexander Ring
8. Fabienne Dominique Schwab
9. Yu Wei Zhang
10. Jianwen Zhou
11. Massimo Saini
12. Karin Strittmatter
13. Selina Budinjas
14. Marko Vujanovic
15. Zacharias Kontarakis
16. Giada Pontecorvi
17. Francesca Albrecht
18. Kirsten D. Mertz
19. Gaël Auray
20. Claudio Giachino
21. Verdon Taylor
22. Ana Gvozdenovic
23. Werner J. Kovacs
24. Ilaria Malanchi
25. Heike Frauchiger-Heuer
26. Andreas Wicki
27. Marcus Vetter
28. Matteo Ligorio
29. Nicola Aceto

Reviewed by Life Science Editors Foundation

A Novel HER2 Protein Identification Methodology in Breast Cancer Cells Using Raman Spectroscopy and Raman Imaging: An Analytical Validation Study

1. Halina Abramczyk
2. Jakub Maciej Surmacki
3. Monika Kopeć

Reviewed by Arcadia Science

Bestrophin-4 relays HES4 and interacts with TWIST1 to suppress epithelial-to-mesenchymal transition in colorectal cancer cells

1. Zijing Wang
2. Bihan Xia
3. Shaochong Qi
4. Xian Zhang
5. Xiaoshuang Zhang
6. Yan Li
7. Huimin Wang
8. Miao Zhang
9. Ziyi Zhao
10. David Kerr
11. Li Yang
12. Shijie Cai
13. Jilin Yang

• Curated by eLife

  eLife Assessment

  The findings of this valuable manuscript advance our understanding of the significance of Bestrophin isoform 4 (BEST4) in suppressing colorectal cancer (CRC) progression. The authors used appropriate and validated methodology, such as the knockout of BEST4 using CRISPR/Cas9 in CRC cells, to provide a solid foundation for elucidating the potential link between BEST4 and CRC progression.

Reviewed by eLife

High-density sampling reveals volume growth in human tumours

1. Arman Angaji
2. Michel Owusu
3. Christoph Velling
4. Nicola Dick
5. Donate Weghorn
6. Johannes Berg

• Curated by eLife

  eLife Assessment

  The article uses a cell-based model to investigate how mutations and cells spread throughout a tumour. The paper uses published data and the proposed model to understand how growth and death mechanisms lead to the observed data. This work provides an important insight into the early stages of tumour development. From the work provided here, the results are convincing, using a thorough analysis.

Reviewed by eLife

Restraint of melanoma progression by cells in the local skin environment

1. Yilun Ma
2. Mohita Tagore
3. Miranda V Hunter
4. Ting-Hsiang Huang
5. Emily Montal
6. Joshua M Weiss
7. Richard M White

• Curated by eLife

  eLife Assessment

  In this important study, the authors used a zebrafish model and scRNAseq analysis to show that a subset of keratinocytes within melanoma microenvironment highly up-regulate Twist and undergo Epithelial-Mesenchymal Transition (EMT). Surprisingly, when overexpressing Twist in keratinocytes, the resulting alteration in keratinocytes is inhibitory for melanoma invasion in both zebrafish and human cell culture models. The results are supported by overall convincing experimental data that provide new insights into the interactions between melanoma cells and their environment.

Reviewed by eLife

ME3BP-7 is a targeted cytotoxic agent that rapidly kills pancreatic cancer cells expressing high levels of monocarboxylate transporter MCT1

1. Jordina Rincon-Torroella
2. Marco Dal Molin
3. Brian Mog
4. Gyuri Han
5. Evangeline Watson
6. Nicolas Wyhs
7. Shun Ishiyama
8. Taha Ahmedna
9. Il Minn
10. Nilofer Azad
11. Chetan Bettegowda
12. Nickolas Papadopoulos
13. Kenneth W Kinzler
14. Shibin Zhou
15. Bert Vogelstein
16. Kathleen Gabrielson
17. Surojit Sur

• Curated by eLife

  eLife assessment

  This study presents a valuable finding and developed ME3BP-7 as a novel microencapsulated formulation of 3BP, which specifically targets MCT1-overexpressing PDAC cells. It demonstrates its specificity and efficacy in vitro and in PDAC mouse models, with significant anti-tumor effects and improved serum stability. Overall, the evidence supporting the authors' claims is solid.

Reviewed by eLife

Super-enhancer-driven ZFP36L1 promotes PD-L1 expression in infiltrative gastric cancer

1. Xujin Wei
2. Jie Liu
3. Jia Cheng
4. Wangyu Cai
5. Wen Xie
6. Kang Wang
7. Lingyun Lin
8. Jingjing Hou
9. Jianchun Cai
10. Huiqin Zhuo

• Curated by eLife

  eLife assessment

  The authors provide useful data to support the existence of a regulatory pathway starting with SPI1-driven ZFP36L1 expression, that goes on to downregulate HDAC3 expression at the transcript level, leading to PD-L1 upregulation due to implied enhanced acetylation of its promoter region. This is therefore an interesting pathway that adds to our understanding of how PD-L1 expression is controlled in gastric cancer. However, this is likely one of many possible pathways that impact PD-L1 expression, and the data are currently incomplete to support the claims made.

Reviewed by eLife

The T cell receptor β chain repertoire of tumor infiltrating lymphocytes improves neoantigen prediction and prioritization

1. Thi Mong Quynh Pham
2. Thanh Nhan Nguyen
3. Bui Que Tran Nguyen
4. Thi Phuong Diem Tran
5. Nguyen My Diem Pham
6. Hoang Thien Phuc Nguyen
7. Thi Kim Cuong Ho
8. Dinh Viet Linh Nguyen
9. Huu Thinh Nguyen
10. Duc Huy Tran
11. Thanh Sang Tran
12. Truong Vinh Ngoc Pham
13. Minh Triet Le
14. Thi Tuong Vy Nguyen
15. Minh-Duy Phan
16. Hoa Giang
17. Hoai-Nghia Nguyen
18. Le Son Tran

• Curated by eLife

  eLife assessment

  The study presents a potentially valuable approach by combining two measurements (pHLA binding and pHLA-TCR binding) to improve predictions of which mutations in colorectal cancer are likely to be presented to and recognised by the immune system. While this approach is promising, the evidence supporting the primary claim remains somewhat incomplete. The experimental validation of the computational predictions with actual immune responses is still limited, despite the increase in sample size from 4 to 8 in this revision.

Reviewed by eLife

TAK1-mediated phosphorylation of PLCE1 represses PIP2 hydrolysis to impede esophageal squamous cancer metastasis

1. Qianqian Ju
2. Wenjing Sheng
3. Meichen Zhang
4. Jing Chen
5. Liucheng Wu
6. Xiaoyu Liu
7. Wentao Fang
8. Hui Shi
9. Cheng Sun

• Curated by eLife

  eLife assessment

  This work provides solid evidence that Transforming Growth Factor β Activated Kinase 1 (TAK1) regulates esophageal squamous cell carcinoma (ESCC) tumor proliferation and metastasis. The findings are valuable to the field of molecular tumor biology in general and to the understanding of ESCC tumor invasiveness and metastatic potential.

Reviewed by eLife

The mitochondrial stress-induced protein carboxyl-terminal alanine and threonine tailing (msiCAT-tailing) promotes glioblastoma tumorigenesis by modulating mitochondrial functions

1. Ting Cai
2. Bei Zhang
3. Esha Reddy
4. Yuanna Wu
5. Yinglu Tang
6. Isha Mondal
7. Jerry Wang
8. Winson S Ho
9. Rongze Olivia Lu
10. Zhihao Wu

• Curated by eLife

  eLife assessment

  Glioblastoma is one of the most aggressive cancers without a cure. Glioblastoma cells are known to have high mitochondrial potential. This useful study demonstrates the critical role of the ribosome-associated quality control (RQC) pathway in regulating mitochondrial membrane potential and glioblastoma growth. Some assays are incomplete; further revision will improve the significance of this study.

Reviewed by eLife