Cancer Biology

STAMBPL1 activates the GRHL3/HIF1A/VEGFA axis through interaction with FOXO1 to promote angiogenesis in triple-negative breast cancer

1. Huan Fang
2. Huichun Liang
3. Chuanyu Yang
4. Dewei Jiang
5. Qianmei Luo
6. Wen-Ming Cao
7. Huifeng Zhang
8. Ceshi Chen

• Curated by eLife

  eLife Assessment

  The study conducted by Fang et al. offers significant and fundamental insights, notably enhancing our understanding of angiogenesis. While some of the claims are supported by convincing experimental approaches, others lack sufficient validation. Additionally, there are instances where critical experimental controls appear to be absent.

Reviewed by eLife

Propionyl-CoA carboxylase subunit B regulates anti-tumor T cells in a pancreatic cancer mouse model

1. Han V Han
2. Richard Efem
3. Barbara Rosati
4. Kevin Lu
5. Sara Maimouni
6. Ya-Ping Jiang
7. Valeria Montoya
8. Ando Van Der Velden
9. Wei-Xing Zong
10. Richard Z Lin

• Curated by eLife

  eLife assessment

  The significance of the findings is valuable, with implications for immunotherapy design in pancreatic ductal adenocarcinoma. The evidence was considered incomplete and partially supportive of the major claims.

Reviewed by eLife

Spatial multi-omics defines a shared glioblastoma infiltrative signature at the resection margin

1. Balagopal Pai
2. Susana Isabel Ramos
3. Wan Sze Cheng
4. Tanvi Joshi
5. Gabrielle Price
6. Jessica Tome-Garcia
7. German Nudelman
8. Sanjana Shroff
9. Kristin Beaumont
10. Yong Raymund
11. Robert Sebra
12. Elena Zaslavsky
13. Nadejda Mincheva Tsankova

Reviewed by PREreview

Tks5 interactome reveals ER-associated machinery translation in invadosomes

1. Léa Normand
2. Benjamin Bonnard
3. Margaux Sala
4. Sylvaine Di-Tommaso
5. Cyril Dourthe
6. Anne-Aurélie Raymond
7. Jean-William Dupuy
8. Luc Mercier
9. Jacky G. Goetz
10. Violaine Moreau
11. Elodie Henriet
12. Frédéric Saltel

Reviewed by Review Commons

Loss of ZNRF3/RNF43 unleashes EGFR in cancer

1. Fei Yue
2. Amy T Ku
3. Payton D Stevens
4. Megan N Michalski
5. Weiyu Jiang
6. Jianghua Tu
7. Zhongcheng Shi
8. Yongchao Dou
9. Yi Wang
10. Xin-Hua Feng
11. Galen Hostetter
12. Xiangwei Wu
13. Shixia Huang
14. Noah F Shroyer
15. Bing Zhang
16. Bart O Williams
17. Qingyun Liu
18. Xia Lin
19. Yi Li

• Curated by eLife

  eLife Assessment

  This manuscript presents solid evidence suggesting that the loss of ZNRF3 and RNF43, two E3 ubiquitin ligases, leads to dysregulation of EGFR signaling in cancer. The authors propose that EGFR is a direct substrate of ZNRF3/RNF43. While the authors provide immunoprecipitation data showing increased detection of ubiquitinated species, this evidence does not definitively establish that EGFR itself is ubiquitinated by RNF43/ZNRF3. The absence of direct evidence for EGFR ubiquitination is a major limitation, although the findings are useful as they may provide novel insights into the mechanisms underlying EGFR-driven cancers and open new therapeutic avenues.

Reviewed by eLife

Systemic and local chronic inflammation and hormone disposition promote a tumor-permissive environment for breast cancer in older women

1. Neil Carleton
2. Sanghoon Lee
3. Ruxuan Li
4. Jian Zou
5. Daniel D Brown
6. Jagmohan Hooda
7. Alexander Chang
8. Rahul Kumar
9. Linda R Klei
10. Lora H Rigatti
11. Joseph Newsome
12. Dixcy Jaba Sheeba John Mary
13. Jennifer M Atkinson
14. Raymond E West
15. Thomas D Nolin
16. Patrick J Oberly
17. Ziyu Huang
18. Donald Poirier
19. Emilia J Diego
20. Peter C Lucas
21. George Tseng
22. Michael T Lotze
23. Priscilla F McAuliffe
24. Ioannis K Zervantonakis
25. Steffi Oesterreich
26. Adrian V Lee

Reviewed by PREreview

NAB2-STAT6 drives an EGR1-dependent neuroendocrine program in solitary fibrous tumors

1. Connor Hill
2. Alexandra Indeglia
3. Francis Picone
4. Maureen E Murphy
5. Cara Cipriano
6. Robert G Maki
7. Alessandro Gardini

• Curated by eLife

  eLife Assessment

  This study provides compelling data regarding the molecular characterization of a rare tumor type with few treatment options. This fundamental work significantly advances our mechanistic understanding of solitary fibrous tumours, a critical first step towards targeted precision medicine approaches. The results of this study will be of broad interest to cancer biologists and experimental oncologists.

Reviewed by eLife

Deuterium metabolic imaging phenotypes mouse glioblastoma heterogeneity through glucose turnover kinetics

1. Rui Vasco Simoes
2. Rafael Neto Henriques
3. Jonas L Olesen
4. Beatriz M Cardoso
5. Francisca F Fernandes
6. Mariana AV Monteiro
7. Sune N Jespersen
8. Tânia Carvalho
9. Noam Shemesh

• Curated by eLife

  eLife Assessment

  This study provides a valuable approach to image and analyze in vivo metabolic flux through glucose turnover kinetics in glioblastoma tumor microenvironments. The evidence for the method's validity is convincing, which establishes the dynamic Deuterium Metabolic Imaging technique as an effective tool enabling non-invasive exploration of various tumors.

Reviewed by eLife

Combinatorial CRISPR screen reveals FYN and KDM4 as targets for synergistic drug combination for treating triple negative breast cancer

1. Tackhoon Kim
2. Byung-Sun Park
3. Soobeen Heo
4. Heeju Jeon
5. Jaeyeal Kim
6. Donghwa Kim
7. Sang Kook Lee
8. So-Youn Jung
9. Sun-Young Kong
10. Timothy Lu

• Curated by eLife

  eLife Assessment

  This study presents a valuable finding that synthetically lethal kinase genes FYN and KDM4 may play a role in drug resistance to kinase inhibitors in TNBC. The evidence supporting the claims of the authors is solid, although the exploration of the upstream mechanisms regulating KDM4A or the downstream pathways through which FYN upregulation confers drug resistance would have strengthened the study. The work will be of interest to medical biologists working in the field of breast cancer.

Reviewed by eLife

Plectin-mediated cytoskeletal crosstalk as a target for inhibition of hepatocellular carcinoma growth and metastasis

1. Zuzana Outla
2. Gizem Oyman-Eyrilmez
3. Katerina Korelova
4. Magdalena Prechova
5. Lukas Frick
6. Lenka Sarnova
7. Piyush Bisht
8. Petra Novotna
9. Jan Kosla
10. Patricia Bortel
11. Yasmin Borutzki
12. Andrea Bileck
13. Christopher Gerner
14. Mohammad Rahbari
15. Nuh Rahbari
16. Emrullah Birgin
17. Bibiana Kvasnicova
18. Andrea Galisova
19. Katerina Sulkova
20. Andreas Bauer
21. Njainday Jobe
22. Ondrej Tolde
23. Eva Sticova
24. Daniel Rösel
25. Tracy O'Connor
26. Martin Otahal
27. Daniel Jirak
28. Mathias Heikenwälder
29. Gerhard Wiche
30. Samuel M Meier-Menches
31. Martin Gregor

• Curated by eLife

  eLife Assessment

  This valuable study investigated the role of PLECTIN, a cytoskeletal crosslinker protein, in hepatocellular carcinoma development and progression. Using a liver-specific Plectin knockout mouse model, the authors showed solid evidence that PLECTIN is critical for hepatocarcinogenesis, since inhibition of PLECTIN suppressed tumor formation in multiple models. They also show that PLECTIN is key for HCC invasion and metastasis. They show a correlation between PLECTIN inhibition and attenuated FAK, MAPK/ERK, and PI3K/AKT signaling.

Reviewed by eLife