Cancer Biology

Prostate cancer associated fibroblasts have distinct morphomechanical features that are associated with patient outcome

1. Antje Garside
2. Angela Jacobi
3. Shivakumar Keerthikumar
4. Vaibhav Mahajan
5. Michelle Richards
6. Birunthi Niranjan
7. Linda Teng
8. Nicholas Choo
9. Gail P Risbridger
10. Mitchell G Lawrence
11. Anna V. Taubenberger

Reviewed by Life Science Editors Foundation

Ezh2 Delays Activation of Differentiation Genes During Normal Cerebellar Granule Neuron Development and in Medulloblastoma

1. James Purzner
2. Alexander S Brown
3. Teresa Purzner
4. Lauren Ellis
5. Sara Broski
6. Ulrike Litzenburger
7. Kaytlin Andrews
8. Aryaman Sharma
9. Xin Wang
10. Michael D Taylor
11. Yoon-Jae Cho
12. Margaret T Fuller
13. Matthew P Scott

• Curated by eLife

  eLife Assessment

  Using an unbiased approach, this important study discovered a role of Ezh2 in the differentiation of granule neuron precursors, the cell of origin for Shh group of medulloblastoma. Furthermore, the authors also provided solid evidence that combined inhibition of Ezh2 and CDK4/6 likely represents a promising strategy for the treatment of this subgroup of MB. Validation of these findings using the FDA-approved Ezh2 inhibitor is needed to further strengthen this preclinical study.

Reviewed by eLife

Notch signaling maintains a progenitor-like subclass of hepatocellular carcinoma

1. Kerstin Seidel
2. Robert Piskol
3. Thi Thu Thao Nguyen
4. Amy Shelton
5. Charisa Cottonham
6. Cecile C de la Cruz
7. Joseph Castillo
8. Jesse Garcia
9. Udi Segal
10. Mark Merchant
11. Yeqing Angela Yang
12. Jasmine Chen
13. Musa Ahmed
14. Alexis Scherl
15. Rajesh Vij
16. Lluc Mosteiro
17. Yan Wu
18. Zora Modrusan
19. Ciara Metcalfe
20. Chris Siebel

• Curated by eLife

  eLife Assessment

  In this valuable study, Seidel et al. identify and characterize a novel subset of hepatocellular carcinoma patient-derived xenograft models defined by active Jagged 1-Notch2 signaling and a distinctive progenitor-like gene expression profile. Within the limitations of the PDX system they used, their methods are state-of-the-art, their data are strong and believable, and their conclusions are convincing. However, the ability to identify HCC patients that might respond is limited, and the mechanistic assessment downstream of JAG1/NOTCH2 is relatively descriptive. Some additional clarifications and experiments would strengthen the paper.

Reviewed by eLife

Spatial multi-omics defines a shared glioblastoma infiltrative signature at the resection margin

1. Balagopal Pai
2. Susana Isabel Ramos
3. Wan Sze Cheng
4. Tanvi Joshi
5. Gabrielle Price
6. Jessica Tome-Garcia
7. German Nudelman
8. Sanjana Shroff
9. Kristin Beaumont
10. Yong Raymund
11. Robert Sebra
12. Elena Zaslavsky
13. Nadejda Mincheva Tsankova

Reviewed by PREreview

Tks5 interactome reveals ER-associated machinery translation in invadosomes

1. Léa Normand
2. Benjamin Bonnard
3. Margaux Sala
4. Sylvaine Di-Tommaso
5. Cyril Dourthe
6. Anne-Aurélie Raymond
7. Jean-William Dupuy
8. Luc Mercier
9. Jacky G. Goetz
10. Violaine Moreau
11. Elodie Henriet
12. Frédéric Saltel

Reviewed by Review Commons