Biophysics

Single-molecule imaging with cell-derived nanovesicles reveals early binding dynamics at a cyclic nucleotide-gated ion channel

1. Vishal R. Patel
2. Arturo M. Salinas
3. Darong Qi
4. Shipra Gupta
5. David J. Sidote
6. Marcel P. Goldschen-Ohm

• Curated by Biophysics Colab

  Endorsement statement (30 August 2021)

  The preprint by Patel et al. describes the development of a single molecule approach for studying individual ligand binding events in membrane proteins within native lipid environments. The approach represents an elegant way to investigate the dynamics of ligand binding, and potential relationships with conformational changes, in molecules embedded within physiological membranes. The work makes an important contribution that will be of interest to scientists working on molecular mechanisms in ion channels and other membrane proteins.

  (This endorsement by Biophysics Colab refers to version 2 of this preprint, which has been revised in response to peer review of version 1.)

Reviewed by Biophysics Colab

Quantitative theory for the diffusive dynamics of liquid condensates

1. Lars Hubatsch
2. Louise M Jawerth
3. Celina Love
4. Jonathan Bauermann
5. TY Dora Tang
6. Stefano Bo
7. Anthony A Hyman
8. Christoph A Weber

• Curated by eLife

  Evaluation Summary:

  This paper will be of broad interest to chemists and biologists studying complex coacervate systems, including biomolecular condensates. Its model provides a new way of obtaining diffusion properties inside and outside the condensates without the necessity of nontrivial assumptions. The model's capability is well presented by applying to experimental data and through further investigating the model through simulations.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

Strikingly Different Roles of SARS-CoV-2 Fusion Peptides Uncovered by Neutron Scattering

1. Andreas Santamaria
2. Krishna C. Batchu
3. Olga Matsarskaia
4. Sylvain F. Prévost
5. Daniela Russo
6. Francesca Natali
7. Tilo Seydel
8. Ingo Hoffmann
9. Valérie Laux
10. Michael Haertlein
11. Tamim A. Darwish
12. Robert A. Russell
13. Giacomo Corucci
14. Giovanna Fragneto
15. Armando Maestro
16. Nathan R. Zaccai

Reviewed by ScreenIT

Allosteric Regulation of 3CL Protease of SARS-CoV-2 and SARS-CoV Observed in the Crystal Structure Ensemble

1. Akinori Kidera
2. Kei Moritsugu
3. Toru Ekimoto
4. Mitsunori Ikeguchi

Reviewed by ScreenIT

Structure-based screening of drug candidates targeting the SARS-CoV-2 envelope protein

1. Xin Xia
2. Yuwei Zhang
3. Songling Li
4. Hengwei Lin
5. Zhiqiang Yan

Reviewed by ScreenIT

Structural dynamics of SARS-CoV-2 nucleocapsid protein induced by RNA binding

1. Helder Veras Ribeiro Filho
2. Gabriel Ernesto Jara
3. Fernanda Aparecida Heleno Batista
4. Gabriel Ravanhani Schleder
5. Celisa Caldana Tonoli
6. Adriana Santos Soprano
7. Samuel Leite Guimarães
8. Antonio Carlos Borges
9. Alexandre Cassago
10. Marcio Chaim Bajgelman
11. Rafael Elias Marques
12. Daniela Barreto Barbosa Trivella
13. Kleber Gomes Franchini
14. Ana Carolina Migliorini Figueira
15. Celso Eduardo Benedetti
16. Paulo Sergio Lopes de Oliveira

Reviewed by ScreenIT

Defective ORF8 dimerization in delta variant of SARS CoV2 leads to abrogation of ORF8 MHC-I interaction and overcome suppression of adaptive immune response

1. Armi M Chaudhari
2. Indra Singh
3. Madhvi Joshi
4. Amrutlal Patel
5. Chaitanya Joshi

Reviewed by ScreenIT

Interaction between Spike Protein of SARS-CoV-2 and Human Virus Receptor ACE2 Using Two-Color Fluorescence Cross-Correlation Spectroscopy

1. Ai Fujimoto
2. Yidan Lyu
3. Masataka Kinjo
4. Akira Kitamura

Reviewed by ScreenIT

Modeling coronavirus spike protein dynamics: implications for immunogenicity and immune escape

1. Genevieve Kunkel
2. Mohammad Madani
3. Simon J. White
4. Paulo H. Verardi
5. Anna Tarakanova

Reviewed by ScreenIT

SARS-CoV-2 spike opening dynamics and energetics reveal the individual roles of glycans and their collective impact

1. Yui Tik Pang
2. Atanu Acharya
3. Diane L. Lynch
4. Anna Pavlova
5. James C. Gumbart

Reviewed by ScreenIT