Bioinformatics

SpaceBF: spatial coexpression analysis using Bayesian fused approaches in spatial omics datasets

1. Souvik Seal
2. Brian Neelon

Reviewed by GigaScience

nf-core/proteinfamilies: a scalable pipeline for the generation of protein families

1. Evangelos Karatzas
2. Martin Beracochea
3. Fotis A Baltoumas
4. Eleni Aplakidou
5. Lorna Richardson
6. James A Fellows Yates
7. Daniel Lundin
8. nf-core community
9. Aydin Buluç
10. Nikos C Kyrpides
11. Ilias Georgakopoulos-Soares
12. Georgios A Pavlopoulos
13. Robert D Finn

Reviewed by GigaScience

The Hok bacterial toxin: diversity, toxicity, distribution and genomic localization

1. Andrés Escalera-Maurer
2. Adriana Messineo
3. Thibaud T. Renault
4. Elena Nicollin
5. Erika Castaneda-Sastre
6. Matthieu Brunot
7. Cléo Berrehail
8. Anaïs Le Rhun

Reviewed by Review Commons

Interpreting the Effects of DNA Polymerase Variants at the Structural Level Using MAVISp and Molecular Dynamics Simulations

1. Matteo Arnaudi
2. Karolina Krzesińska
3. Ludovica Beltrame
4. Pablo Sánchez-Izquierdo Besora
5. Matteo Tiberti
6. Mef Nilbert
7. Anna Rohlin
8. Elena Papaleo

Reviewed by Review Commons

A genotype-phenotype transformer to assess and explain polygenic risk

1. Ingoo Lee
2. Zachary S. Wallace
3. Yuqi Wang
4. Sungjoon Park
5. Hojung Nam
6. Amit R. Majithia
7. Trey Ideker

Reviewed by Review Commons

Comparative evaluation of computational methods for reconstruction of human viral genomes

1. Maria J. P. Sousa
2. Mari Toppinen
3. Lari Pyöriä
4. Klaus Hedman
5. Antti Sajantila
6. Maria F. Perdomo
7. Diogo Pratas

Reviewed by GigaScience

An integrative multiomics random forest framework for robust biomarker discovery

1. Wei Zhang
2. Hanchen Huang
3. Lily Wang
4. Brian D Lehmann
5. X Steven Chen

Reviewed by GigaScience

Squidly harnesses enzyme functional hierarchy and contrastive learning to efficiently predict catalytic residues from sequence

1. William JF Rieger
2. Mikael Bodén
3. Frances Arnold
4. Ariane Mora

• Curated by eLife

  eLife Assessment

  This important contribution to enzyme annotation offers a deep learning framework for catalytic site prediction. Integrating biochemical knowledge with large language models, the authors demonstrate how to extract meaningful information from sequence alone. They introduce Squidly, a freely available new ML modeling framework, that outperforms existing tools on standard benchmarks, including the CataloDB dataset. The evidence is convincing, with an extensively and carefully addressed narrative upon revision.

Reviewed by eLife

Generative modeling for RNA splicing prediction and design

1. Di Wu
2. Natalie Maus
3. Anupama Jha
4. Kevin Yang
5. Benjamin D Wales-McGrath
6. San Jewell
7. Anna Tangiyan
8. Peter Choi
9. Jake R Gardner
10. Yoseph Barash

• Curated by eLife

  eLife Assessment

  TrASPr is an important contribution that leverages transformer models focused on regulatory regions to enhance predictions of tissue-specific splicing events. The revisions strengthen the manuscript by clarifying methodology and expanding analyses across exon and intron sizes, and the evidence supporting TrASPr's predictive performance is compelling. This work will be of interest to researchers in computational genomics and RNA biology, offering an improved model for splicing prediction and a promising approach to RNA sequence design.

Reviewed by eLife

Beyond P-values: A Multi-Metric Framework for Robust Feature Selection and Predictive Modeling

1. Raelynn Chen
2. Attri Ghosh
3. Jie Hu
4. Yong Chen
5. Jason H. Moore
6. Ruowang Li

Reviewed by Arcadia Science