Bioengineering

Rationally designed multimeric nanovaccines using icosahedral DNA origami for molecularly controlled display of SARS-CoV-2 receptor binding domain

1. Qingqing Feng
2. Keman Cheng
3. Lizhuo Zhang
4. Xiaoyu Gao
5. Jie Liang
6. Guangna Liu
7. Nana Ma
8. Chen Xu
9. Ming Tang
10. Liting Chen
11. Xinwei Wang
12. Xuehui Ma
13. Jiajia Zou
14. Quanwei Shi
15. Pei Du
16. Qihui Wang
17. Guangjun Nie
18. Xiao Zhao

Reviewed by Rapid Reviews Infectious Diseases

Kinetic properties of optogenetic site-specific DNA recombination by LiCre- loxP

1. Alice Dufour
2. Hélène Duplus-Bottin
3. Thomas Boukéké-Lesplulier
4. Eliane Casassa
5. Gérard Triqueneaux
6. Léo Tarbouriech
7. Camille Darthenay-Kiennemann
8. Agnès Dumont
9. Catherine Moali
10. Franck Vittoz
11. Daniel Jost
12. Gaël Yvert

Reviewed by Review Commons

RamanBot: Versatile high throughput Raman system

1. Khaled Atia
2. Robert Hunter
3. Meshach Asare-Werehene
4. Benjamin K. Tsang
5. Hanan Anis

Reviewed by Arcadia Science

Matrix viscoelasticity regulates dendritic cell migration and immune priming

1. Wei-Hung Jung
2. Emie Humann
3. Joshua M Price
4. Yoav Binenbaum
5. Azra Haseki
6. Sanjana Iyer
7. Daivd J Mooney

Reviewed by preLights

Glycogen Engineering Improves the Starvation Resistance of Mesenchymal stem cells and their Therapeutic Efficacy in Pulmonary Fibrosis

1. Yongyue Xu
2. Mamatali Rahman
3. Zhaoyan Wang
4. Bo Zhang
5. Hanqi Xie
6. Lei Wang
7. Haowei Xu
8. Xiaodan Sun
9. Shan Cheng
10. Qiong Wu

• Curated by eLife

  eLife Assessment

  This important study presents a novel approach to enhance the therapeutic potential of mesenchymal stromal cells (MSCs) by genetically modifying their glycogen synthesis pathway, resulting in increased glycogen accumulation and improved cell survival under starvation conditions, particularly in the context of experimental pulmonary fibrosis. The methods and findings are generally solid and could be strengthened in the future by investigating the kinetics of persistence, the immunomodulatory effects, and the underlying improved mechanism of action of MSCs in this pulmonary fibrosis model. If confirmed, this approach could suggest potential methods to improve the therapeutic functionality of MSCs in cell therapy strategies.

Reviewed by eLife

Comparing Linear and Nonlinear Finite Element Models of Vertebral Strength Across the Thoracolumbar Spine: A Benchmark from Density-Calibrated Computed Tomography

1. Matthias Walle
2. Bryn E. Matheson
3. Steven K. Boyd

Reviewed by GigaScience

Dissecting organoid-bacteria interaction highlights decreased contractile force as a key factor for heart infection

1. Anheng Wang
2. Jiaxian Wang
3. Zhe Zhang
4. Chuan Yang
5. Chunhao Deng
6. Guokai Chen
7. Chengwu Li
8. Qian Wang
9. Lei Dong
10. Chunming Wang

• Curated by eLife

  eLife Assessment

  This manuscript reports important findings that have theoretical or practical implications beyond a single subfield. However, despite the combination of numerous analytical tools established and applied in the study, the work has substantial experimental limitations leading to incomplete evidence, indicating that the conclusions may be an over-interpretation of the findings.

Reviewed by eLife

XAI-based Data Visualization in Multimodal Medical Data

1. Sahil Sharma
2. Muskaan Singh
3. Liam McDaid
4. Saugat Bhattacharyya

Reviewed by PREreview

Targeted Computational Design of an Interleukin-7 Superkine with Enhanced Folding Efficiency and Immunotherapeutic Efficacy

1. See-Khai Lim
2. Wen-Ching Lin
3. Yi-Chung Pan
4. Sin-Wei Huang
5. Yao-An Yu
6. Cheng-Hung Chang
7. Che-Ming Jack Hu
8. Chung-Yuan Mou
9. Kurt Yun Mou

• Curated by eLife

  eLife Assessment

  This important study presents the rational redesign and engineering of interleukin-7. The data from the integrated approach of using computational, biophysical, and cellular experiments are convincing, but this study can further benefit from more quantitative analyses and structural data. This paper is broadly relevant to those studying immunomodulation using biologics.

Reviewed by eLife

The heterogeneity of dermal mesenchymal cells reproduced in skin equivalents regulates barrier function and elasticity

1. Shun Kimura
2. Sachiko Sekiya
3. Sawa Yamashiro
4. Tetsutaro Kikuchi
5. Masatoshi Haga
6. Tatsuya Shimizu

Reviewed by Review Commons