1. CRISPR-Edited DPSCs, Constitutively Expressing BDNF Enhance Dentin Regeneration in Injured Teeth

    This article has 6 authors:
    1. Ji Hyun Kim
    2. Muhammad Irfan
    3. Sreelekshmi Sreekumar
    4. Stephanie Kim
    5. Atsawasuwan Phimon
    6. Seung Chung
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study provides a potentially useful investigation into the positive role of BDNF/TrkB signaling in implanted dental pulp stem cells to enhance dentin regeneration in the context of dental caries. Some of the key methods used need to be much better documented, and the data should be strengthened and added to in support of several of the claims of functional benefit, which are inadequately supported at present. Additional details for the validation of the reagents and techniques are needed to support the interpretation of the results.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. Mitochondrial adenine base editing of mouse somatic tissues via adeno-associated viral delivery

    This article has 6 authors:
    1. Christian D Mutti
    2. Lindsey Van Haute
    3. Lucia Luengo-Gutierrez
    4. Keira Turner
    5. Pedro Silva-Pinheiro
    6. Michal Minczuk
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The authors have demonstrated the use of adenine base editors delivered via adeno-associated viruses to introduce edits in the mitochondrial genome. The manuscript describes the methodology well, and the conclusions are convincingly supported by the results. The valuable results highlight the potential of these base editors to model mtDNA variations in somatic tissues in animal models.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  3. Scaly-Tail Organ Enhances Static Stability during Pel’s Scaly-tailed Flying Squirrels’ Arboreal Locomotion

    This article has 6 authors:
    1. Andrew K. Schulz
    2. Mrudul Chellapurath
    3. Pranav C. Khandelwal
    4. SeyedReza Rezaei
    5. Stefan Merker
    6. Ardian Jusufi

    Reviewed by preLights

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  4. Semantical and Geometrical Protein Encoding Toward Enhanced Bioactivity and Thermostability

    This article has 5 authors:
    1. Yang Tan
    2. Bingxin Zhou
    3. Lirong Zheng
    4. Guisheng Fan
    5. Liang Hong
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      ProtSSN is a valuable approach that generates protein embeddings by integrating sequence and structural information, demonstrating improved prediction of mutation effects on thermostability compared to competing models. The evidence supporting the authors' claims is compelling, with well-executed comparisons. This work will be of particular interest to researchers in bioinformatics and structural biology, especially those focused on protein function and stability.

    Reviewed by eLife

    This article has 11 evaluationsAppears in 1 listLatest version Latest activity
  5. DyAb: sequence-based antibody design and property prediction in a low-data regime

    This article has 16 authors:
    1. Joshua Yao-Yu Lin
    2. Jennifer L. Hofmann
    3. Andrew Leaver-Fay
    4. Wei-Ching Liang
    5. Stefania Vasilaki
    6. Edith Lee
    7. Pedro O. Pinheiro
    8. Natasa Tagasovska
    9. James R. Kiefer
    10. Yan Wu
    11. Franziska Seeger
    12. Richard Bonneau
    13. Vladimir Gligorijevic
    14. Andrew Watkins
    15. Kyunghyun Cho
    16. Nathan C. Frey

    Reviewed by Arcadia Science

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  6. Gut-on-Chip Methodology Based on 3D-Printed Molds: A Cost-Effective and Accessible Approach

    This article has 5 authors:
    1. Elise Delannoy
    2. Aurélie Burette
    3. Sébastien Janel
    4. Catherine Daniel
    5. Alexandre Grassart

    Reviewed by Arcadia Science

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  7. Discovery of Expression-Governing Residues in Proteins

    This article has 7 authors:
    1. Fan Jiang
    2. Mingchen Li
    3. Banghao Wu
    4. Liang Zhang
    5. Bozitao Zhong
    6. Yuanxi Yu
    7. Liang Hong

    Reviewed by Arcadia Science

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  8. AI-enabled alkaline-resistant evolution of protein to apply in mass production

    This article has 10 authors:
    1. Liqi Kang
    2. Banghao Wu
    3. Bingxin Zhou
    4. Pan Tan
    5. Yun (Kenneth) Kang
    6. Yongzhen Yan
    7. Yi Zong
    8. Shuang Li
    9. Zhuo Liu
    10. Liang Hong
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important work demonstrates the application of Pro-PRIME, a large language model, to engineer VHH antibodies with enhanced stability for extreme industrial environments. The evidence is convincing, showing through two rounds of design and experimental validation that AI-guided approaches can outperform traditional rational design methods. The solid methodology and results establish a foundation for further exploration of LLM-assisted protein engineering.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  9. Compositional editing of extracellular matrices by CRISPR/Cas9 engineering of human mesenchymal stem cell lines

    This article has 13 authors:
    1. Sujeethkumar Prithiviraj
    2. Alejandro Garcia Garcia
    3. Karin Linderfalk
    4. Bai Yiguang
    5. Sonia Ferveur
    6. Ludvig Nilsén Falck
    7. Agatheeswaran Subramaniam
    8. Sofie Mohlin
    9. David Hidalgo
    10. Steven J Dupard
    11. Dimitra Zacharaki
    12. Deepak Bushan Raina
    13. Paul E Bourgine
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The study presents a potentially valuable approach to genetically modify cells to produce extracellular matrices with altered compositions, termed cell-laid, engineered extracellular matrices (eECM). The evidence supporting the authors' conclusions regarding the utility of eECM for endogenous repair is solid, although there are some disagreements on the chondrogenicity of lyophilized constructs which was viewed as lacking robust evidence for endochondral ossification.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  10. Coagulative Granular Hydrogels with an Enzyme Catalyzed Fibrin Network for Endogenous Tissue Regeneration

    This article has 10 authors:
    1. Zhipeng Deng
    2. Camila B. Tovani
    3. Simona Bianco
    4. Gianni Comandini
    5. Aya Elghajiji
    6. Dave J. Adams
    7. Fabrizio Scarpa
    8. Michael R. Whitehouse
    9. Annela M. Seddon
    10. James P. K. Armstrong

    Reviewed by preLights

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
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