Biochemistry

Viral proteins activate PARIS-mediated tRNA degradation and viral tRNAs rescue infection

1. Nathaniel Burman
2. Svetlana Belukhina
3. Florence Depardieu
4. Royce A. Wilkinson
5. Mikhail Skutel
6. Andrew Santiago-Frangos
7. Ava B. Graham
8. Alexei Livenskyi
9. Anna Chechenina
10. Natalia Morozova
11. Trevor Zahl
12. William S. Henriques
13. Murat Buyukyoruk
14. Christophe Rouillon
15. Lena Shyrokova
16. Tatsuaki Kurata
17. Vasili Hauryliuk
18. Konstantin Severinov
19. Justine Groseille
20. Agnès Thierry
21. Romain Koszul
22. Florian Tesson
23. Aude Bernheim
24. David Bikard
25. Blake Wiedenheft
26. Artem Isaev

Reviewed by Rapid Reviews Infectious Diseases

Aggregation-dependent epitope sequence and modification fingerprints of anti-Aβ antibodies

1. Ivan Talucci
2. Timon Leske
3. Hans-Wolfgang Klafki
4. Mohammed Mehedi Hassan
5. Annik Steiert
6. Barbara Morgado
7. Sebastian Bothe
8. Lars van Werven
9. Thomas Liepold
10. Jochen Walter
11. Hermann Schindelin
12. Jens Wiltfang
13. Oliver Wirths
14. Olaf Jahn
15. Hans Michael Maric

• Curated by eLife

  eLife Assessment

  Antibodies that selectively bind distinct amyloid-beta variants are vital tools for Alzheimer's disease research. This valuable manuscript aims to delineate the epitope specificity in a panel of anti-amyloid-beta antibodies, including some with clinical relevance. The experiments were rigorously conducted, employing an interesting combination of established and state-of-the-art methodologies, yielding convincing findings.

Reviewed by eLife

Inhibition of NF-κB Signaling by the Reactive Glycolytic Metabolite Methylglyoxal

1. Caroline Stanton
2. Woojin Choi
3. R. Luke Wiseman
4. Michael J. Bollong

Reviewed by preLights

The malate–aspartate shuttle supports thermogenic lipid mobilization in brown adipocytes

1. Michaela Veliova
2. Caroline M. Ferreira
3. Katrina P. Montales
4. Francisco Villalobos
5. Alexandra J. Brownstein
6. Rebeca Acín‐Pérez
7. Gabrielly S. Ferreira
8. Anthony E. Jones
9. Linsey Stiles
10. Ajit S. Divakaruni
11. Marc Liesa
12. Orian S. Shirihai
13. Marcus F. Oliveira

Reviewed by Review Commons

NanoBlocks: creating fluorescent biosensors from affinity binders using competitive binding

1. Silke Denis
2. Vincent Van Deuren
3. Desiree I. Frecot
4. Ulrich Rothbauer
5. Shehab Ismail
6. Alison G. Tebo
7. Peter Dedecker

Reviewed by Arcadia Science

Intrinsic specificity of a ‘core’ TIP60 acetyltransferase complex in Drosophila

1. Silke Krause
2. Marco Borsò
3. Marisa Müller
4. Axel Imhof
5. Zivkos Apostolou
6. Peter B. Becker

Reviewed by Review Commons

Computational design of pH-sensitive binders

1. Green Ahn
2. Brian Coventry
3. Ella Haefner
4. Shayan Sadre
5. Jenny Hu
6. Mimosa Van
7. Buwei Huang
8. Isaac Sappington
9. Adam J. Broerman
10. Mauriz A. Lichtenstein
11. Matthias Glögl
12. Inna Goreshnik
13. Dionne Vafeados
14. David Baker

Reviewed by preLights

Integrated Respirometry and Metabolomics Unveil Circadian Metabolic Dynamics in Drosophila

1. Farheen Akhtar
2. Dania Malik
3. Arjun Sengupta
4. Paula Haynes
5. Jaco Klok
6. Amita Sehgal
7. Aalim M Weljie

• Curated by eLife

  eLife Assessment

  This study investigates how sleep loss and circadian disruption affect whole-organ metabolism in flies (Drosophila melanogaster) and reports that wild-type flies align metabolism in anticipation of diurnal rhythm, while mutant flies with impaired sleep or circadian function shift to reactive or misaligned metabolism. The integration of chamber-based flow-through respirometry with LC-MS metabolomics is innovative, and the significance of the findings is valuable. However, the strength of evidence needed to support the conclusions is incomplete based on concerns regarding the inappropriate use of constant darkness to disrupt circadian rhythms and the lack of details justifying the methods used to correlate respirometry data with whole-body metabolomics.

Reviewed by eLife

Structure-based Design of Chimeric Influenza Hemagglutinins to Elicit Cross-group Immunity

1. Karla M Castro
2. Reyhaneh Ayardulabi
3. Sarah Wehrle
4. Hongrui Cui
5. Sandrine Georgeon
6. Joseph Schmidt
7. Shuhao Xiao
8. Nishat Seraj
9. Wayne Harshbarger
10. Corey P Mallett
11. Ventzislav Vassilev
12. Xavier Saelens
13. Bruno E Correia

• Curated by eLife

  eLife Assessment

  This important study presents a thoughtful design and characterization of chimeric influenza hemagglutinin (HA) head domains combining elements of distinct receptor-binding sites. The results provide convincing evidence that polyclonal cross-group responses to influenza A virus can be elicited by a single immunization. While the mechanistic basis of heterotrimer formation and immunodominance differences remains unclear, the authors provide new insights for protein design, vaccinology, and computational vaccine design.

Reviewed by eLife

Cryo‐EM structures of multiple‐peptide resistance factor ( MprF ) from Pseudomonas aeruginosa

1. Shaileshanand Jha
2. Kutti R. Vinothkumar

Reviewed by Review Commons