Biochemistry

The High Transmission of SARS-CoV-2 Omicron (B.1.1.529) Variant is Not Only Due to Its hACE2 binding: A Free Energy of Perturbation Study

1. Filip Fratev

Reviewed by ScreenIT

Interactions of SARS-CoV-2 protein E with cell junctions and polarity PDZ-containing proteins

1. Yanlei Zhu
2. Flavio Alvarez
3. Nicolas Wolff
4. Ariel Mechaly
5. Sébastien Brûlé
6. Benoit Neitthoffer
7. Sandrine Etienne-Manneville
8. Ahmed Haouz
9. Batiste Boëda
10. Célia Caillet-Saguy

Reviewed by ScreenIT

Alzheimer's Aβ assembly binds sodium pump and blocks endothelial NOS activity via ROS-PKC pathway in brain vascular endothelial cells

1. Tomoya Sasahara
2. Kaori Satomura
3. Mari Tada
4. Akiyoshi Kakita
5. Minako Hoshi

• Curated by eLife

  Evaluation Summary:

  This paper examines the effects of amylospheroids, highly neurotoxic assemblies of β-amyloid, on aortic function and on cultured cells. The authors propose that the interaction of amylospheroids with the sodium pump in endothelial cells induces production of reactive oxygen species to ultimately comprise nitric oxide generation. The study provides some new insight into mechanisms underlying brain blood vessel dysfunction and will be interesting neuroscientists who study neurovascular contribution to neurodegenerative diseases. The conclusions of the manuscript are supported by the data, but alternative approaches would make the study stronger.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

Possible Interference in Protein – Protein interaction as a new approach in microinhibition of respiratory pathogens on nasal– oral epithelium: An early on-screen study with reference toSARS-Cov-2–ACE2 binding interference

1. Debatosh Datta
2. Suyash Pant
3. Devendra Kumar Dhaked
4. Somasundaram Arumugam
5. Ravichandiran Velayutham
6. Pallab Datta

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Delta Variant with P681R Critical Mutation Revealed by Ultra-Large Atomic-Scale Ab Initio Simulation: Implications for the Fundamentals of Biomolecular Interactions

1. Puja Adhikari
2. Bahaa Jawad
3. Praveen Rao
4. Rudolf Podgornik
5. Wai-Yim Ching

Reviewed by ScreenIT

Main protease mutants of SARS-CoV-2 variants remain susceptible to nirmatrelvir

1. Sven Ullrich
2. Kasuni B. Ekanayake
3. Gottfried Otting
4. Christoph Nitsche

Reviewed by ScreenIT

Coiled coil control of growth factor and inhibitor-dependent EGFR trafficking and degradation

1. Deepto Mozumdar
2. Sol Hsun-Hui Chang
3. Kim Quach
4. Amy Doerner
5. Alanna Schepartz

• Curated by eLife

  Evaluation Summary:

  This manuscript investigates the cellular role of the juxtamembrane region in the EGF receptor, a poorly understood portion of the EGFR cytosolic domain that connects the transmembrane segment to the kinase domain. Through a series of well-designed experiments, the work shows that the endocytic trafficking route of EGFR following its activation is determined by the juxtamembrane coiled-coil conformation in a model cell line. This finding is important for three reasons. It identifies a critical role for the juxtamembrane region; it resolves the discrepancy that TGF-beta dissociation from EGFR is supposed to occur at higher pH, yet the EGFR-TGF-beta complex continues to signal from endosomes; and it pinpoints the mechanism of EGFR inhibition by a new class of tyrosine kinase inhibitors.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. All reviewers agreed to share their names with the authors.)

Reviewed by eLife

Stabilization of the SARS-CoV-2 receptor binding domain by protein core redesign and deep mutational scanning

1. Alison C Leonard
2. Jonathan J Weinstein
3. Paul J Steiner
4. Annette H Erbse
5. Sarel J Fleishman
6. Timothy A Whitehead

Reviewed by ScreenIT

Neurotoxic Amyloidogenic Peptides Identified in the Proteome of SARS-COV2: Potential Implications for Neurological Symptoms in COVID-19

1. Saba Islam
2. Mirren Charnley
3. Guneet Bindra
4. Julian Ratcliffe
5. Jiangtao Zhou
6. Raffaele Mezzenga
7. Mark Hulett
8. Kyunghoon Han
9. Joshua T. Berryman
10. Nicholas P. Reynolds

Reviewed by ScreenIT

Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease

1. Vasundara Srinivasan
2. Hévila Brognaro
3. Prince R. Prabhu
4. Edmarcia Elisa de Souza
5. Sebastian Günther
6. Patrick Y. A. Reinke
7. Thomas J. Lane
8. Helen Ginn
9. Huijong Han
10. Wiebke Ewert
11. Janina Sprenger
12. Faisal H. M. Koua
13. Sven Falke
14. Nadine Werner
15. Hina Andaleeb
16. Najeeb Ullah
17. Bruno Alves Franca
18. Mengying Wang
19. Angélica Luana C. Barra
20. Markus Perbandt
21. Martin Schwinzer
22. Christina Schmidt
23. Lea Brings
24. Kristina Lorenzen
25. Robin Schubert
26. Rafael Rahal Guaragna Machado
27. Erika Donizette Candido
28. Danielle Bruna Leal Oliveira
29. Edison Luiz Durigon
30. Stephan Niebling
31. Angelica Struve Garcia
32. Oleksandr Yefanov
33. Julia Lieske
34. Luca Gelisio
35. Martin Domaracky
36. Philipp Middendorf
37. Michael Groessler
38. Fabian Trost
39. Marina Galchenkova
40. Aida Rahmani Mashhour
41. Sofiane Saouane
42. Johanna Hakanpää
43. Markus Wolf
44. Maria Garcia Alai
45. Dusan Turk
46. Arwen R. Pearson
47. Henry N. Chapman
48. Winfried Hinrichs
49. Carsten Wrenger
50. Alke Meents
51. Christian Betzel

Reviewed by ScreenIT