Biochemistry

Structural insights into human propionyl-CoA carboxylase (PCC) and 3-methylcrotonyl-CoA carboxylase (MCC)

1. Fayang Zhou
2. Yuanyuan Zhang
3. Yuyao Zhu
4. Qiang Zhou
5. Yigong Shi
6. Qi Hu

• Curated by eLife

  eLife Assessment

  This study presents the cryo-EM structures of two human biotin-dependent mitochondria carboxylases involved in various biological pathways, including the metabolism of certain amino acids, cholesterol, and odd chain fatty acids. The cryo-EM structures offer a valuable addition to the structural description of biotin-dependent carboxylases and provide solid evidence to support the major conclusions of this study. This paper would be of interest to biochemists and structural biologists working on biotin-dependent carboxylases.

Reviewed by eLife

The intrinsically disordered N-terminus of SUMO1 is an intramolecular inhibitor of SUMO1 interactions

1. Sebastian M Richter
2. Fan Jin
3. Tobias Ritterhoff
4. Aleksandra Fergin
5. Eric Maurer
6. Andrea Frank
7. Michael Daube
8. Alex Hajnal
9. Rachel Klevit
10. Frauke Gräter
11. Annette Flotho
12. Frauke Melchior

• Curated by eLife

  eLife assessment

  This work demonstrates an important regulatory role of the N-terminal disordered tail of small ubiquitin-like modifier (SUMO) proteins, which modulate the function of various proteins in eukaryotic cells. The authors present convincing evidence that the N-terminal tail of SUMO inhibits SUMO's interaction with downstream effector proteins and SUMOylation targets, and that this regulatory mechanism depends on the SUMO paralogue or the phosphorylation of the N-terminal tail. This discovery significantly advances the field by providing a possible explanation of how SUMO paralogues select their effectors and SUMOylation targets.

Reviewed by eLife

Bioorthogonal labeling of chitin in pathogenic Candida species reveals biochemical mechanisms of hyphal growth and homeostasis

1. Caroline Williams
2. Bella R. Carnahan
3. Stephen N. Hyland
4. Catherine L. Grimes

Reviewed by PREreview

Evolutionarily divergent Mycobacterium tuberculosis CTP synthase filaments are under selective pressure

1. Eric M. Lynch
2. Yao Lu
3. Jin Ho Park
4. Lin Shao
5. Justin Kollman
6. E. Hesper Rego

Reviewed by PREreview