Biochemistry | Sciety

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10.1101/2024.05.04.592262
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10.1101/2023.12.18.572223
Biochemical and structural insights into the auto-inhibited state of Mical1 and its activation by Rab8

This article has 4 authors:
1. Amrita Rai
2. Petra Janning
3. Ingrid R Vetter
4. Roger S Goody
This article has been curated by 1 group:
- Curated by eLife
  
  eLife Assessment
  
  This fundamental study addresses the regulation of the MICAL-family of actin regulators by Rab GTPases, which play a key role in directing membrane trafficking within cells. The compelling evidence explains how Rab8 family members bind at two sites to allosterically regulate MICAL1, and relieve an auto-inhibited state unable to bind actin. This study lays the basis for further progress in understanding membrane trafficking and cytoskeleton dynamics in eukaryotic cells.
Reviewed by eLife

This article has 3 evaluationsAppears in 1 listLatest version Nov 15, 2024Latest activity Nov 14, 2024
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10.1101/2024.05.30.596652
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10.1101/2024.01.26.577428
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10.1101/2024.08.06.606792
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10.1101/2024.05.15.594037

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