Biochemistry

Proximity Interactome analyses unveil novel regulators of IRE1α canonical signaling

1. Simon Le Goupil
2. Céline Philippe
3. Hadrien Laprade
4. Mathéo Lode
5. Rachel Boniface
6. Diana Pelizzari-Raymundo
7. Kurt Dejgaard
8. Gregor Jansen
9. Celia Limia
10. Claudio Hetz
11. S. Jalil Mahdizadeh
12. Luc Negroni
13. Marc Aubry
14. Jean-Ehrland Ricci
15. Leif A. Eriksson
16. Eric Chevet

Reviewed by Review Commons

Reduction of DNA Topoisomerase Top2 Reprograms the Epigenetic Landscape and Extends Health and Life Span Across Species

1. Man Zhu
2. Meng Ma
3. Lunan Luo
4. Feiyang Li
5. Jiashun Zheng
6. Yan Pan
7. Lu Yang
8. Ying Xiao
9. Ziyan Wang
10. Bo Xian
11. Yi Zheng
12. Hao Li
13. Jing Yang

• Curated by eLife

  eLife Assessment

  Building on earlier evidence that Topoisomerase 2 depletion can extend yeast lifespan, the authors present convincing data demonstrating that reduced Top2 levels confer significant longevity benefits in C. elegans and mice. They show that these benefits encompass not only extended survival but also improved healthspan and mitigation of aging phenotypes, supported by robust transcriptomic, epigenetic, and histological analyses. While the exact mechanistic underpinnings-such as the potential connection to classical aging pathways and the selective down-regulation of genes with active promoters-remain to be fully elucidated, the breadth of these important findings strongly indicates a conserved role for Top2 in aging regulation.

Reviewed by eLife

Enzymatic access to the rare ΔUA (1→4) Glc 3, 6, N-sulfated heparin disaccharide, implications for heparin quality control

1. T. K. Kandola
2. C. J. Mycroft-West
3. M. L. Andrade De Lima
4. A. Turner
5. C. Gardini
6. E. Urso
7. G.J. Miller
8. A. Bisio
9. E. A. Yates
10. M. Guerrini
11. L. Wu
12. M. A. Skidmore

Reviewed by preLights

Curcuma longa Essential Oil Topically Mitigates Inflammatory Markers in Acetone-Induced Atopic Dermatitis in Wistar Albino Rats

1. Nathiim Namale
2. Deusdedit Tusubira
3. Kenneth Male
4. Angela Mumbua Musyoka
5. Patrick Maduabuchi Aja

Reviewed by Arcadia Science

The conserved biochemical activity and function of an early metazoan phosphatidylinositol 5 phosphate 4-kinase regulates growth and development

1. Harini Krishnan
2. Suhail Muzaffar
3. Sanjeev Sharma
4. Visvanathan Ramya
5. Avishek Ghosh
6. Ramanathan Sowdhamini
7. Padinjat Raghu

Reviewed by Review Commons

Medium-sized protein language models perform well at transfer learning on realistic datasets

1. Luiz C. Vieira
2. Morgan L. Handojo
3. Claus O. Wilke

Reviewed by Arcadia Science