Biochemistry

Alzheimer-mutant γ-secretase complexes stall amyloid β-peptide production

1. Parnian Arafi
2. Sujan Devkota
3. Emily Williams
4. Masato Maesako
5. Michael S Wolfe

• Curated by eLife

  eLife Assessment

  This manuscript provides fundamental studies to gain insight into the mutations in the presenilin-1 (PSEN1) gene on proteolytic processing of the amyloid precursor protein (APP). The authors provide compelling evidence using mutations in PSEN to understand what drives alternative substrate turnover with convincing data and rigorous analysis. This deep mechanistic study provides a framework towards the development of small molecule inhibitors to treat AD.

Reviewed by eLife

Enzymatic access to the rare ΔUA (1→4) Glc 3, 6, N-sulfated heparin disaccharide, implications for heparin quality control

1. T. K. Kandola
2. C. J. Mycroft-West
3. M. L. Andrade De Lima
4. A. Turner
5. C. Gardini
6. E. Urso
7. G.J. Miller
8. A. Bisio
9. E. A. Yates
10. M. Guerrini
11. L. Wu
12. M. A. Skidmore

Reviewed by preLights

Curcuma longa Essential Oil Topically Mitigates Inflammatory Markers in Acetone-Induced Atopic Dermatitis in Wistar Albino Rats

1. Nathiim Namale
2. Deusdedit Tusubira
3. Kenneth Male
4. Angela Mumbua Musyoka
5. Patrick Maduabuchi Aja

Reviewed by Arcadia Science

Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant

1. Patsy R Tomlinson
2. Rachel G Knox
3. Olga Perisic
4. Helen Su
5. Gemma V Brierley
6. Roger L Williams
7. Robert K Semple

• Curated by eLife

  eLife Assessment

  This important study reports on PI3KR mutations and a paradoxical mechanism of PI3KR signaling. The strength of evidence for the study is mostly convincing, as conclusions are supported by a variety of mutational strategies and cellular systems to look at interactions among signaling pathways.

Reviewed by eLife

The conserved biochemical activity and function of an early metazoan phosphatidylinositol 5 phosphate 4-kinase regulates growth and development

1. Harini Krishnan
2. Suhail Muzaffar
3. Sanjeev Sharma
4. Visvanathan Ramya
5. Avishek Ghosh
6. Ramanathan Sowdhamini
7. Padinjat Raghu

Reviewed by Review Commons

Medium-sized protein language models perform well at transfer learning on realistic datasets

1. Luiz C. Vieira
2. Morgan L. Handojo
3. Claus O. Wilke

Reviewed by Arcadia Science

Acetylation of RORβ by histone acetyltransferase p300 and deacetylation by SIRT1 modulates receptor stability, turnover and transcriptional activity

1. Timothy O’Leary
2. Denis Shutin
3. Dean P. Edwards
4. Patrick R. Griffin
5. Mi Ra Chang

Reviewed by Arcadia Science

Computational enzyme design by catalytic motif scaffolding

1. Markus Braun
2. Adrian Tripp
3. Morakot Chakatok
4. Sigrid Kaltenbrunner
5. Celina Fischer
6. David Stoll
7. Aleksandar Bijelic
8. Wael Elaily
9. Massimo G. Totaro
10. Melanie Moser
11. Shlomo Y. Hoch
12. Horst Lechner
13. Federico Rossi
14. Matteo Aleotti
15. Mélanie Hall
16. Gustav Oberdorfer

Reviewed by PREreview

Allosteric modulation of the Lon protease by effector binding and local charges

1. Justyne L Ogdahl
2. Peter Chien

Reviewed by PREreview

Mechanistic studies of small molecule ligands selective to RNA single G bulges

1. Shalakha Hegde
2. Sana Akhter
3. Zhichao Tang
4. Chang Qi
5. Chenguang Yu
6. Anna Lewicka
7. Yu Liu
8. Kushal Koirala
9. Mikhail Reibarkh
10. Kevin P Battaile
11. Anne Cooper
12. Scott Lovell
13. Erik D Holmstrom
14. Xiao Wang
15. Joseph A Piccirilli
16. Qi Gao
17. Yinglong Miao
18. Jingxin Wang

Reviewed by PREreview