Biochemistry

Tryptanthrin Analogs Substoichiometrically Inhibit Seeded and Unseeded Tau4RD Aggregation

1. Ellie I James
2. David W Baggett
3. Edcon Chang
4. Joel Schachter
5. Thomas Nixey
6. Karoline Choi
7. Miklos Guttman
8. Abhinav Nath

• Curated by eLife

  eLife assessment

  This study provides a valuable contribution to the development of small molecules that inhibit the aggregation of tau, a protein involved in several neurodegenerative diseases. The authors present convincing evidence that analogs of the plant alkaloid tryptanthrin can prevent the formation of larger aggregates by targeting the early stages of tau oligomerization. Nevertheless, further studies are needed to elucidate the precise mechanisms of action and to provide a detailed kinetic analysis. This work will be of interest to biochemists and biophysicists focused on designing small molecules to inhibit fibril formation.

Reviewed by eLife

Effects of Gallic Acid on Antioxidant Defense System in Mice with Benzene-Induced Myelotoxicity

1. Toba Isaac Olatoye
2. Joseph O. Adebayo

Reviewed by PREreview

Structural basis for CCR6 modulation by allosteric antagonists

1. David Jonathan Wasilko
2. Brian S. Gerstenberger
3. Kathleen A. Farley
4. Wei Li
5. Jennifer Alley
6. Mark E. Schnute
7. Ray J. Unwalla
8. Jorge Victorino
9. Kimberly K. Crouse
10. Ru Ding
11. Parag V. Sahasrabudhe
12. Fabien Vincent
13. Richard K. Frisbie
14. Alpay Dermenci
15. Andrew Flick
16. Chulho Choi
17. Gary Chinigo
18. James J. Mousseau
19. John I. Trujillo
20. Philippe Nuhant
21. Prolay Mondal
22. Vincent Lombardo
23. Daniel Lamb
24. Barbara J. Hogan
25. Gurdeep Singh Minhas
26. Elena Segala
27. Christine Oswald
28. Ian W. Windsor
29. Seungil Han
30. Mathieu Rappas
31. Robert M. Cooke
32. Matthew F. Calabrese
33. Gabriel Berstein
34. Atli Thorarensen
35. Huixian Wu

Reviewed by PREreview

SARS-CoV-2 methyltransferase nsp10-16 in complex with natural and drug-like purine analogs for guiding structure-based drug discovery

1. Viviane Kremling
2. Sven Falke
3. Yaiza Fernández-García
4. Christiane Ehrt
5. Antonia Kiene
6. Bjarne Klopprogge
7. Emilie Scheer
8. Fabian Barthels
9. Philipp Middendorf
10. Sebastian Kühn
11. Stephan Günther
12. Matthias Rarey
13. Henry N Chapman
14. Dominik Oberthür
15. Janina Sprenger

• Curated by eLife

  eLife assessment

  This important study describes the crystallographic screening of a number of small molecules against a viral enzyme critical for the 5' capping of SARS-CoV-2 RNA and viral replication. While the high-quality crystal structures and complementary biophysical assays in this study provide solid evidence to support the major claims regarding how these small molecule compounds bind to the viral enzyme, the mismatch between the antiviral activity and binding to the viral enzyme of several small molecule compounds could have been more thoroughly investigated or discussed. This paper would be of interest to the fields of coronavirus biology, structural biology, and drug discovery.

Reviewed by eLife

The LC3-interacting region of NBR1 is a protein interaction hub enabling optimal flux

1. Brian J. North
2. Amelia E. Ohnstad
3. Michael J. Ragusa
4. Christopher J. Shoemaker

Reviewed by Review Commons

Proteome of human glioblastoma and meningioma tissue small extracellular vesicles

1. Huaqi Su
2. Adityas Purnianto
3. Andrew Kaye
4. Andrew Morokoff
5. Katherine j Drummond
6. Stanley Stylli
7. Laura J Vella

Reviewed by Arcadia Science

Structural characterization of DNA-binding domain of essential mammalian protein TTF 1

1. Gajender Singh
2. Abhinetra Jagdish Bhopale
3. Saloni Khatri
4. Prashant Prakash
5. Rajnish Kumar
6. Sukh Mahendra Singh
7. Samarendra Kumar Singh

Reviewed by Arcadia Science

Effect of truffle extracts on growth of Chlorella vulgaris

1. Anfisa A. Vlasova
2. Olga E. Lipatova
3. Alexander Y. Belyshenko
4. Elena I. Martynova
5. Natalia A. Imidoeva
6. Tamara Y. Telnova
7. Ekaterina V. Malygina
8. Maria M. Morgunova
9. Maria E. Dmitrieva
10. Victoria N. Shelkovnikova
11. Sophia S. Shashkina
12. Tatiana N. Vavilina
13. Denis V. Axenov-Gribanov

Reviewed by Arcadia Science

Specific proteolysis mediated by a p97-directed proteolysis-targeting chimera (PROTAC)

1. Constanza Salinas-Rebolledo
2. Javier Blesa
3. Guillermo Valenzuela-Nieto
4. David Schwefel
5. Natalia López González del Rey
6. Maxs Méndez-Ruette
7. Janine Burkhalter
8. Luis Federico Bátiz
9. Ronald Jara
10. José A. Obeso
11. Pedro Chana-Cuevas
12. Gopal P. Sapkota
13. Alejandro Rojas-Fernandez

Reviewed by Review Commons

Plasticity of the proteasome-targeting signal Fat10 enhances substrate degradation

1. Hitendra Negi
2. Aravind Ravichandran
3. Pritha Dasgupta
4. Shridivya Reddy
5. Ranabir Das

• Curated by eLife

  eLife assessment

  This manuscript probes the ways in which a protein tag might influence the structure, dynamics and stability of a covalently-attached substrate protein. Such findings are of important significance to several fields, particularly in understanding how these influences control the abundance of proteins within a cell. The evidence provided to support the authors' conclusions are, however, incomplete and further control experiments are necessary to fully support the proposed model.

Reviewed by eLife