Biochemistry

Acetylation-Primed SUMOylation Drives RORβ Turnover via a p300-SIRT1 Regulatory Axis

1. Timothy R. O’Leary
2. Denis Shutin
3. Nadeska I. Montalvan
4. Nereida M. Abad-Yang
5. Vuong Dang
6. Dean P. Edwards
7. Patrick R. Griffin
8. Mi Ra Chang

Reviewed by Arcadia Science

Computational enzyme design by catalytic motif scaffolding

1. Markus Braun
2. Adrian Tripp
3. Morakot Chakatok
4. Sigrid Kaltenbrunner
5. Celina Fischer
6. David Stoll
7. Aleksandar Bijelic
8. Wael Elaily
9. Massimo G. Totaro
10. Melanie Moser
11. Shlomo Y. Hoch
12. Horst Lechner
13. Federico Rossi
14. Matteo Aleotti
15. Mélanie Hall
16. Gustav Oberdorfer

Reviewed by PREreview

Allosteric modulation of the Lon protease by effector binding and local charges

1. Justyne L Ogdahl
2. Peter Chien

Reviewed by PREreview

Mechanistic studies of small molecule ligands selective to RNA single G bulges

1. Shalakha Hegde
2. Sana Akhter
3. Zhichao Tang
4. Chang Qi
5. Chenguang Yu
6. Anna Lewicka
7. Yu Liu
8. Kushal Koirala
9. Mikhail Reibarkh
10. Kevin P Battaile
11. Anne Cooper
12. Scott Lovell
13. Erik D Holmstrom
14. Xiao Wang
15. Joseph A Piccirilli
16. Qi Gao
17. Yinglong Miao
18. Jingxin Wang

Reviewed by PREreview

Protonation/deprotonation-driven switch for the redox stability of low-potential [4Fe-4S] ferredoxin

1. Kei Wada
2. Kenji Kobayashi
3. Iori Era
4. Yusuke Isobe
5. Taigo Kamimura
6. Masaki Marukawa
7. Takayuki Nagae
8. Kazuki Honjo
9. Noriko Kaseda
10. Yumiko Motoyama
11. Kengo Inoue
12. Masakazu Sugishima
13. Katsuhiro Kusaka
14. Naomine Yano
15. Keiichi Fukuyama
16. Masaki Mishima
17. Yasutaka Kitagawa
18. Masaki Unno

• Curated by eLife

  eLife Assessment

  Ferredoxins are ubiquitous electron transfer proteins that drive essential metabolic processes across all domains of life. This fundamental contribution to the field provides the first description of how specific amino acids, though a series of hydrogen bonds, control the ability of iron-sulfur clusters in ferrodoxins to accept and donate electrons. The evidence supporting the conclusions is compelling as is the combined use of neutron crystallography with X-ray crystallography and classical spectral/redox studies.

Reviewed by eLife

Interactions with multiple inner kinetochore proteins determine mitotic localization of FACT

1. Julia Schweighofer
2. Bhagyashree Mulay
3. Ingrid Hoffmann
4. Doro Vogt
5. Marion E. Pesenti
6. Andrea Musacchio

Reviewed by Review Commons

Seeing Double: Molecular dynamics simulations reveal the stability of certain alternate protein conformations in crystal structures

1. Aviv A. Rosenberg
2. Sanketh Vedula
3. Alex M. Bronstein
4. Ailie Marx

Reviewed by PREreview

Increased bone inflammation in type 2 diabetes and obesity correlates with Wnt signaling downregulation and reduced bone strength

1. Giulia Leanza
2. Malak Faraj
3. Francesca Cannata
4. Viola Viola
5. Niccolò Pellegrini
6. Flavia Tramontana
7. Claudio Pedone
8. Gianluca Vadalà
9. Alessandra Piccoli
10. Rocky Strollo
11. Francesca Zalfa
12. Roberto Civitelli
13. Mauro Maccarrone
14. Rocco Papalia
15. Nicola Napoli

• Curated by eLife

  eLife Assessment

  This is a convincing paper that addresses topics important in our understanding of how inflammatory markers are modulated in both obesity and type 2 diabetes and their effects on Wnt signaling mediators in human bone. There are changes in bone at the tissue level in these 2 common metabolic disorders that ultimately lead to compromised bone strength. These data will be critical to our understanding of the pathophysiology of skeletal fragility in obesity and diabetes.

Reviewed by eLife