Biochemistry

  5. In vivo exchange of glucose and lactate between photoreceptors and the retinal pigment epithelium

    1. Daniel T Hass
    2. Elizabeth Giering
    3. John YS Han
    4. Celia M Bisbach
    5. Kriti Pandey
    6. Brian M Robbings
    7. Thomas O Mundinger
    8. Nicholas D Nolan
    9. Stephen H Tsang
    10. Neal S Peachey
    11. Nancy J Philp
    12. James B Hurley

    • Curated by eLife

      eLife Assessment

      This research is valuable as it investigates metabolic shuttling between photoreceptors and retinal pigment epithelium (RPE) using in vivo infusion techniques and mouse models. The authors find that the retina significantly relies on circulating glucose, with photoreceptors being the primary consumers of glucose, which is convincing. However, the study has incomplete evidence to support the claims that photoreceptors can use lactate as a fuel source, that lactate exported from photoreceptors is utilized by the RPE, and that lactate contributes to the TCA cycle in the RPE. These claims need substantial revision to include potential alternative explanations or perform key experiments.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  6. Unconventional structure and function of PHD domains from additional sex combs‐like proteins

    1. Cameron J. Reddington
    2. Annabel R. Walsh
    3. Torsten Kleffmann
    4. Christoph Göbl
    5. Peter D. Mace

    Reviewed by Review Commons

    3 evaluationsAppears in 1 listLatest version Latest activity

  7. Butyrolactol A enhances caspofungin efficacy via flippase inhibition in drug-resistant fungi

    1. Xuefei Chen
    2. H. Diessel Duan
    3. Michael J. Hoy
    4. Kalinka Koteva
    5. Michaela Spitzer
    6. Allison K. Guitor
    7. Emily Puumala
    8. Aline A. Fiebig
    9. Guanggan Hu
    10. Bonnie Yiu
    11. Sommer Chou
    12. Zhuyun Bian
    13. Yeseul Choi
    14. Amelia Bing Ya Guo
    15. Wenliang Wang
    16. Sheng Sun
    17. Nicole Robbins
    18. Anna Floyd Averette
    19. Michael A. Cook
    20. Ray Truant
    21. Lesley T. MacNeil
    22. Eric D. Brown
    23. James W. Kronstad
    24. Brian K. Coombes
    25. Leah E. Cowen
    26. Joseph Heitman
    27. Huilin Li
    28. Gerard D. Wright

    Reviewed by PREreview

    1 evaluationAppears in 2 listsLatest version Latest activity

  9. Hepatic HKDC1 deletion alleviates western diet-induced MASH in mice

    1. Kai Xu
    2. Irene Corona-Avila
    3. María Dolores Frutos
    4. María Ángeles Núñez-Sánchez
    5. Dhruvi Makhanasa
    6. Pratham Viral Shah
    7. Grace Guzman
    8. Bruno Ramos-Molina
    9. Medha Priyadarshini
    10. Md. Wasim Khan

    Reviewed by PREreview, Arcadia Science

    6 evaluationsAppears in 2 listsLatest version Latest activity

  10. Protein codes promote selective subcellular compartmentalization

    1. Henry R. Kilgore
    2. Itamar Chinn
    3. Peter G. Mikhael
    4. Ilan Mitnikov
    5. Catherine Van Dongen
    6. Guy Zylberberg
    7. Lena Afeyan
    8. Salman F. Banani
    9. Susana Wilson-Hawken
    10. Tong Ihn Lee
    11. Regina Barzilay
    12. Richard A. Young

    Reviewed by Arcadia Science

    1 evaluationAppears in 1 listLatest version Latest activity
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