1. Allosteric modulation by the fatty acid site in the glycosylated SARS-CoV-2 spike

    This article has 9 authors:
    1. A. Sofia F. Oliveira
    2. Fiona L. Kearns
    3. Mia A. Rosenfeld
    4. Lorenzo Casalino
    5. Imre Berger
    6. Christiane Schaffitzel
    7. Andrew D. Davidson
    8. Rommie E. Amaro
    9. Adrian J. Mulholland
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This manuscript focuses on understanding if and how the glycosylation of SARS-CoV2 spike protein affects a putative allosteric network of interactions controlled by the binding of a fatty acid. The main conclusion is that glycans do not significantly affect the network of allosteric interactions. This useful information - albeit mainly consisting of negative results - is based on solid evidence. It will be of interest to scientists focusing on SARS CoV2 protein structure and dynamics.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. Effects of Gallic Acid on Antioxidant Defense System in Mice with Benzene-Induced Myelotoxicity

    This article has 2 authors:
    1. Toba Isaac Olatoye
    2. Joseph O. Adebayo

    Reviewed by PREreview

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  3. Structural basis for CCR6 modulation by allosteric antagonists

    This article has 35 authors:
    1. David Jonathan Wasilko
    2. Brian S. Gerstenberger
    3. Kathleen A. Farley
    4. Wei Li
    5. Jennifer Alley
    6. Mark E. Schnute
    7. Ray J. Unwalla
    8. Jorge Victorino
    9. Kimberly K. Crouse
    10. Ru Ding
    11. Parag V. Sahasrabudhe
    12. Fabien Vincent
    13. Richard K. Frisbie
    14. Alpay Dermenci
    15. Andrew Flick
    16. Chulho Choi
    17. Gary Chinigo
    18. James J. Mousseau
    19. John I. Trujillo
    20. Philippe Nuhant
    21. Prolay Mondal
    22. Vincent Lombardo
    23. Daniel Lamb
    24. Barbara J. Hogan
    25. Gurdeep Singh Minhas
    26. Elena Segala
    27. Christine Oswald
    28. Ian W. Windsor
    29. Seungil Han
    30. Mathieu Rappas
    31. Robert M. Cooke
    32. Matthew F. Calabrese
    33. Gabriel Berstein
    34. Atli Thorarensen
    35. Huixian Wu

    Reviewed by PREreview

    This article has 1 evaluationAppears in 3 listsLatest version Latest activity
  4. SARS-CoV-2 methyltransferase nsp10-16 in complex with natural and drug-like purine analogs for guiding structure-based drug discovery

    This article has 15 authors:
    1. Viviane Kremling
    2. Sven Falke
    3. Yaiza Fernández-García
    4. Christiane Ehrt
    5. Antonia Kiene
    6. Bjarne Klopprogge
    7. Emilie Scheer
    8. Fabian Barthels
    9. Philipp Middendorf
    10. Sebastian Kühn
    11. Stephan Günther
    12. Matthias Rarey
    13. Henry N Chapman
    14. Dominik Oberthür
    15. Janina Sprenger
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study describes the crystallographic screening of a number of small molecules against a viral enzyme critical for the 5' capping of SARS-CoV-2 RNA and viral replication. While the high-quality crystal structures and complementary biophysical assays in this study provide solid evidence to support the major claims regarding how these small molecule compounds bind to the viral enzyme, the mismatch between the antiviral activity and binding to the viral enzyme of several small molecule compounds could have been more thoroughly investigated or discussed. This paper would be of interest to the fields of coronavirus biology, structural biology, and drug discovery.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  5. Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPARγ

    This article has 2 authors:
    1. Jinsai Shang
    2. Douglas J Kojetin
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This fundamental study uncovers the detailed structural mechanisms by which covalent and non-covalent synthetic ligands can simultaneously occupy the binding pocket of the nuclear receptor transcription factor PPARγ. Supported by a compelling set of structural, biochemical, and biophysical data, the findings challenge the reliability of two widely used covalent inhibitors and have broader implications for nuclear receptor research. This study will interest structural biologists and biochemists investigating the binding mechanisms of ligands targeting the nuclear receptor superfamily.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  6. The LC3-interacting region of NBR1 is a protein interaction hub enabling optimal flux

    This article has 4 authors:
    1. Brian J North
    2. Amelia E Ohnstad
    3. Michael J Ragusa
    4. Christopher J Shoemaker

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  7. Proteome of human glioblastoma and meningioma tissue small extracellular vesicles

    This article has 7 authors:
    1. Huaqi Su
    2. Adityas Purnianto
    3. Andrew Kaye
    4. Andrew Morokoff
    5. Katherine j Drummond
    6. Stanley Stylli
    7. Laura J Vella

    Reviewed by Arcadia Science

    This article has 2 evaluationsAppears in 1 listLatest version Latest activity
  8. Structural Characterization of DNA Binding Domain of Essential Mammalian Protein TTF 1

    This article has 7 authors:
    1. Gajender Singh
    2. Abhinetra Jagdish Bhopale
    3. Saloni Khatri
    4. Prashant Prakash
    5. Rajnish Kumar
    6. Sukh Mahendra Singh
    7. Samarendra Kumar Singh

    Reviewed by Arcadia Science

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  9. Effect of truffle extracts on growth of Chlorella vulgaris

    This article has 13 authors:
    1. Anfisa A. Vlasova
    2. Olga E. Lipatova
    3. Alexander Y. Belyshenko
    4. Elena I. Martynova
    5. Natalia A. Imidoeva
    6. Tamara Y. Telnova
    7. Ekaterina V. Malygina
    8. Maria M. Morgunova
    9. Maria E. Dmitrieva
    10. Victoria N. Shelkovnikova
    11. Sophia S. Shashkina
    12. Tatiana N. Vavilina
    13. Denis V. Axenov-Gribanov

    Reviewed by Arcadia Science

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  10. Dimer-monomer transition defines a novel hyper-thermostable peptidoglycan hydrolase mined from bacterial proteome

    This article has 12 authors:
    1. Li Zhang
    2. Fen Hu
    3. Zirong Zhao
    4. Xinfeng Li
    5. Mingyue Zhong
    6. Jiajun He
    7. Fangfang Yao
    8. Xiaomei Zhang
    9. Yuxuan Mao
    10. Hongping Wei
    11. Jin He
    12. Hang Yang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable study explores a new strategy of lysin-derived antimicrobial peptide-primed screening to find peptidoglycan hydrolases from bacterial proteomes. Using this strategy, the authors identified five peptidoglycan hydrolases from Acinetobacter baumannii, which they tested on various Gram-positive and Gram-negative pathogens for antimicrobial activity. The data presented are solid and will be of interest to microbiologists.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity