Biochemistry

Integrating computational protein structure predictions and genetic dependencies yields an atlas of human multi-protein complexes (AHMPC)

1. Michael Uckelmann
2. Daniel Alvarez Salmoral
3. Carmen Maiella
4. Onno Bleijerveld
5. Ceri Zwart
6. Eric Marcus
7. Joren Brunekreef
8. Jonas Teuwen
9. Roderick Beijersbergen
10. Anastassis Perrakis

Reviewed by Review Commons

The structure of Egalitarian in complex with the K10 mRNA localization signal reveals a modular binding surface required for function

1. Zebin Hong
2. Li Jin
3. Jonas Mühle
4. Fulvia Bono

• Curated by eLife

  eLife Assessment

  This manuscript has convincing data that provides a high-resolution structure of the Egl-RNA complex. The findings are important to understand the formation, stability, and interactions of this complex. However, the manuscript could be improved by conducting a rigorous statistical analysis, a deeper understanding of apparent discrepancies in the stoichiometric Egl-to-RNA ratio, and exploring the specificity of this complex using a more diverse set of control RNAs.

Reviewed by eLife

Exogenous Amyloid Sequences: Their Role in Amyloid-Beta Heterotypic Aggregation

1. Jofre Seira Curto
2. Marina Romero Ruiz
3. Genís Pérez Collell
4. Sandra Villegas
5. Maria Rosario Fernandez
6. Natalia Sanchez de Groot

Reviewed by preLights

A potential anti-amyloidogenic therapy for type 2 diabetes based on the QBP1 peptide

1. María M. Tejero-Ojeda
2. Ada Bernaus Vives
3. Michal Wojciechowski
4. Dinh Quoc Huy Pham
5. Mateusz Chwastyk
6. Mario Vallejo
7. Anna Novials
8. Mariano Carrión-Vázquez

Reviewed by preLights