Evaluated articles

Balancing stability and flexibility when reshaping archaeal membranes

1. Miguel Amaral
2. Felix Frey
3. Xiuyun Jiang
4. Buzz Baum
5. Anđela Šarić

• Curated by eLife

  eLife Assessment

  This fundamental study characterizes the mechanics and stability of bolalipids from archaeal membranes using a minimalist, physics-based computational model. The authors present a robust mesoscale model of bolalipids-containing membranes, systematically evaluating it across diverse membrane configurations. The results are compelling, demonstrating that the incorporation of bolalipids and regular bilayer lipids in archaeal membranes significantly enhances membrane fluidity and structural stability.

Reviewed by eLife, Arcadia Science

Toward De Novo Protein Design from Natural Language

1. Fengyuan Dai
2. Shiyang You
3. Yudian Zhu
4. Yuan Gao
5. Lihao Fu
6. Xibin Zhou
7. Jin Su
8. Chentong Wang
9. Yuliang Fan
10. Xiaoxiao Ma
11. Xianjun Deng
12. Letong Yu
13. Hui Qian
14. Yan He
15. Yitao Ke
16. Chenchen Han
17. Xing Chang
18. Liangzhen Zheng
19. Sheng Wang
20. Yajie Wang
21. Anping Zeng
22. Shunzhi Wang
23. Tong Si
24. Jianming Liu
25. Hongyuan Lu
26. Fajie Yuan

Reviewed by Arcadia Science

Varicose-projection astrocytes: a reactive phenotype associated with neuropathology

1. Caterina Ciani
2. Giulio Pistorio
3. Simona Giancola
4. Marika Mearelli
5. Francesca Emma Mongelli
6. Delaram Forouzeh
7. Luca Mio
8. Paula Ramos-Gonzalez
9. Carlos Matute
10. Ugne Kuliesiute
11. Sari Elena Dötterer
12. Gediminas Luksys
13. Saulius Rocka
14. Urte Neniskyte
15. Marya Ayub
16. Jean-Marie Graïc
17. Francesco Petrelli
18. Alexei Verkhratsky
19. Nunzio Iraci
20. Fabio Cavaliere
21. Carmen Falcone

Reviewed by Arcadia Science

Self-Organizing Neural Networks in Novel Moving Bodies: Anatomical, Behavioral, and Transcriptional Characterization of a Living Construct with a Nervous System

1. Haleh Fotowat
2. Laurie O’Neill
3. Léo Pio-Lopez
4. Megan Sperry
5. Patrick Erickson
6. Tiffany Lin
7. Michael Levin

Reviewed by Arcadia Science

Inferring genotype-phenotype maps using attention models

1. Krishna Rijal
2. Caroline M. Holmes
3. Samantha Petti
4. Gautam Reddy
5. Michael M. Desai
6. Pankaj Mehta

Reviewed by Arcadia Science

Free‐Form Microfluidic Microneedle Array Patches

1. Ian A. Coates
2. Madison M. Driskill
3. Netra U. Rajesh
4. Gabriel Lipkowitz
5. Dan Ilyn
6. Yue Xu
7. Maria T. Dulay
8. Gunilla B. Jacobson
9. John R. Tumbleston
10. Jillian L. Perry
11. Shaomin Tian
12. Joseph M. DeSimone

Reviewed by Arcadia Science

Life as a Function: Why Transformer Architectures Struggle to Gain Genome-Level Foundational Capabilities

1. Hassan Hassan
2. Kyle Puhger
3. Ali Saadat
4. Johannes Mayer
5. Maximilian Sprang

Reviewed by Arcadia Science

Evolution of gene order in prokaryotes is driven primarily by gene gain and loss

1. Shelly Brezner
2. Sofya K. Garushyants
3. Yuri I. Wolf
4. Eugene V. Koonin
5. Sagi Snir

Reviewed by Arcadia Science

The visual system of the longest-living vertebrate, the Greenland shark

1. Lily G. Fogg
2. Emily Tom
3. Maxime Policarpo
4. William Cho
5. Fangyuan Gao
6. Steven F. Grieco
7. Doreen Hii
8. Aaron E. Fawcett
9. Nicolas Boileau
10. Amalie Bech-Poulsen
11. Kirstine F. Steffensen
12. Cherlyn J Ng
13. Peter G. Bushnell
14. John Fleng Steffensen
15. Richard Brill
16. Walter Salzburger
17. Dorota Skowronska-Krawczyk

Reviewed by Arcadia Science

Low-dimensional genotype-fitness mapping across divergent environments suggests a limiting functions model of fitness

1. Olivia M. Ghosh
2. Grant Kinsler
3. Benjamin H. Good
4. Dmitri A. Petrov

Reviewed by Arcadia Science

Evolutionary adaptations of TRPA1 thermosensitivity and skin thermoregulation in vertebrates

1. Gabriel E. Bertolesi
2. Neda Heshami
3. Sarah McFarlane

Reviewed by Arcadia Science

The retinoic acid receptor regulates development of a key evolutionary novelty - the molluscan shell

1. Keisuke Shimizu
2. Paul A. O’Neill
3. Kazuyoshi Endo
4. Tetsuhiro Kudoh

Reviewed by Arcadia Science

Contributions of T helper 9 cells in endometriosis-associated inflammation and lesion growth

1. Alison McCallion
2. Katherine B. Zutautas
3. Danielle J. Sisnett
4. Priyanka Yolmo
5. Harshavardhan Lingegowda
6. Asha K. Ravishanker
7. Dan Vo Hoang
8. Chandrakant Tayade

Reviewed by Arcadia Science

Machine learning-assisted enzyme engineering through ultra-high throughput sorting and large-scale sequence-function data generation

1. Jingyun Zhang
2. Sangeetha Shanmugam
3. Jing Wui Yeoh
4. Dan Zheng
5. Jan Ron Goh
6. Zhangyuan Lin
7. Chueh Loo Poh

Reviewed by Arcadia Science

Dominant contribution of Asgard archaea to eukaryogenesis

1. Victor Tobiasson
2. Jacob Luo
3. Yuri I Wolf
4. Eugene V Koonin

Reviewed by Arcadia Science

Scaling and merging macromolecular diffuse scattering with mdx2

1. Steve P. Meisburgera
2. Nozomi Andob

Reviewed by Arcadia Science

Closest relatives of poxviruses are spread in the gut of humans and animals worldwide: the egoviruses

1. Morgan Gaïa
2. Hans-Joachim Ruscheweyh
3. A. Murat Eren
4. Eugene V. Koonin
5. Shinichi Sunagawa
6. Mart Krupovic
7. Tom O. Delmont

Reviewed by Arcadia Science

The structure of an ancient genotype–phenotype map shaped the functional evolution of a protein family

1. Santiago Herrera-Álvarez
2. Jaeda E. J. Patton
3. Joseph W. Thornton

Reviewed by Arcadia Science

ESM-Effect: An Effective and Efficient Fine-Tuning Framework towards accurate prediction of Mutation’s Functional Effect

1. Moritz Glaser
2. Johannes Brägelmann

Reviewed by Arcadia Science

Anti-citrullinated protein antibodies arise during affinity maturation of germline antibodies to carbamylated proteins in rheumatoid arthritis

1. Marta Escarra-Senmarti
2. Michael Chungyoun
3. Dylan Ferris
4. Jeffrey J. Gray
5. Felipe Andrade

Reviewed by Arcadia Science