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  1. Mast cells promote pathology and susceptibility in tuberculosis

    This article has 14 authors:
    1. Ananya Gupta
    2. Vibha Taneja
    3. Javier Rangel Moreno
    4. Abhimanyu
    5. Mushtaq Ahmed
    6. Nilofer Naqvi
    7. Kuldeep S Chauhan
    8. Daniela Trejo-Ponce de León
    9. Gustavo Ramírez-Martínez
    10. Luis Jiménez-Alvarez
    11. Cesar Luna-Rivero
    12. Joaquin Zuniga
    13. Deepak Kaushal
    14. Shabaana A Khader
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this useful study, the authors use published scRNA-seq data to highlight the importance of mast cells (MCs) in TB granulomas, reporting a comparative assessment of chymase- and tryptase-expressing MCs in the lungs of tuberculosis-infected individuals and non-human primates, with MC-deficient mice showing reduced lung bacterial burden and pathology during infection. Whilst the findings are helpful, the evidence to support conclusions is inconsistent across models and thus incomplete. Specifically, the data supporting a role for MCs in coordinating cytokine responses to modulate pathology, susceptibility to tuberculosis, and dissemination during infection are weak.

    Reviewed by eLife, Arcadia Science

    This article has 6 evaluationsAppears in 2 listsLatest version Latest activity
  2. Mechanical Centrosome Fracturing during Cell Navigation

    This article has 11 authors:
    1. Madeleine T. Schmitt
    2. Mauricio J.A. Ruiz-Fernandez
    3. Kasia Stefanowski
    4. Janina Kroll
    5. Robert Hauschild
    6. Jack Merrin
    7. Thomas Penz
    8. Eva Kiermaier
    9. Christoph Bock
    10. Tobias Straub
    11. Jörg Renkawitz

    Reviewed by Arcadia Science

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  3. Intestinal helminth skews DC2 development towards regulatory phenotype to counter the anti-helminth immune response

    This article has 16 authors:
    1. Anna Andrusaite
    2. Olivia Ridgewell
    3. Anna Ahlback
    4. Holly Webster
    5. Hiroki Yamaguchi
    6. Molly Peel
    7. Annika Frede
    8. Sarwah Al-Khalidi
    9. Andrew Farthing
    10. Anna Heawood
    11. Annabelle Smith
    12. Edward Roberts
    13. Allan Mowat
    14. Richard Maizels
    15. Georgia Perona-Wright
    16. Simon Milling

    Reviewed by Arcadia Science

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity