Evaluated articles

Recording γ-secretase activity in living mouse brains

1. Steven S. Hou
2. Yuya Ikegawa
3. Yeseo Kwon
4. Mei C.Q. Houser
5. Brianna Lundin
6. Brian J. Bacskai
7. Oksana Berezovska
8. Masato Maesako

• Curated by eLife

  eLife assessment

  Hou and colleagues describe the the use of a previously characterized FRET sensor for use in determining gamma secretase activity in the brain of living mice. In an approach that targeted the sensor to neurons, they observe patterns of fluorescent sensor readout suggesting clustered regions of secretase activity. These results once validated would be valuable in the field of Alzheimer's Disease research, yet further validation of the approach is required, as the current evidence provided is inadequate to support the conclusions.

Reviewed by eLife, Arcadia Science

Staphylococcus aureus counters organic acid anion-mediated inhibition of peptidoglycan cross-linking through robust alanine racemase activity

1. Sasmita Panda
2. Yahani P. Jayasinghe
3. Dhananjay D. Shinde
4. Emilio Bueno
5. Amanda Stastny
6. Blake P. Bertrand
7. Sujata S. Chaudhari
8. Tammy Kielian
9. Felipe Cava
10. Donald R. Ronning
11. Vinai C. Thomas

• Curated by eLife

  eLife assessment

  In this valuable study, the authors use Staphylococcus aureus to understand how organic acids inhibit bacterial growth. They provide convincing evidence that acetic acid specifically inhibits the activity of the Ddl enzyme and that S. aureus maintains a high intracellular D-ala concentration to circumvent acetate-mediated growth inhibition. This work will be of interest to researchers studying bacteria and antimicrobials.

Reviewed by eLife, Arcadia Science

Revealing global stoichiometry conservation architecture in cells from Raman spectral patterns

1. Ken-ichiro F. Kamei
2. Koseki J. Kobayashi-Kirschvink
3. Takashi Nozoe
4. Hidenori Nakaoka
5. Miki Umetani
6. Yuichi Wakamoto

Reviewed by Arcadia Science

Growing a cystic fibrosis-relevant polymicrobial biofilm to probe community phenotypes

1. Sarah Poirier
2. Fabrice Jean-Pierre

Reviewed by Arcadia Science

The LH receptor regulates hippocampal spatial memory and restores dendritic spine density in ovariectomized APP/PS1 AD mice

1. Megan Mey
2. Sabina Bhatta
3. Sneha Suresh
4. Luis Montero Labrador
5. Helen Piontkivska
6. Gemma Casadesus

Reviewed by Arcadia Science

High-volume, label-free imaging for quantifying single-cell dynamics in induced pluripotent stem cell colonies

1. Anthony Asmar
2. Zack Benson
3. Adele P. Peskin
4. Joe Chalfoun
5. Mylene Simon
6. Michael Halter
7. Anne Plant

Reviewed by Arcadia Science

Phylogenomics reveals coincident divergence between giant host sea anemones and the clownfish adaptive radiation

1. Aurelien De Jode
2. Andrea M. Quattrini
3. Tommaso Chiodo
4. Marymegan Daly
5. Catherine S. McFadden
6. Michael L. Berumen
7. Christopher P. Meyer
8. Suzanne Mills
9. Ricardo Beldade
10. Aaron Bartholomew
11. Anna Scott
12. James D Reimer
13. Kensuke Yanagi
14. Takuma Fuji
15. Estefanía Rodríguez
16. Benjamin M. Titus

Reviewed by Arcadia Science

Excessive F-Actin and Microtubule Formation Mediates Primary Cilia Shortening and Loss in Response to Increased Extracellular Osmotic Pressure

1. Hiroshi Otani
2. Ryota Nakazato
3. Faryal Ijaz
4. Kanae Koike
5. Koji Ikegami

Reviewed by Arcadia Science

Pinpointing the microbiota of tardigrades: what is really there?

1. Bartłomiej Surmacz
2. Daniel Stec
3. Monika Prus-Frankowska
4. Mateusz Buczek
5. Łukasz Michalczyk
6. Piotr Łukasik

Reviewed by Arcadia Science

AutoPeptideML: A study on how to build more trustworthy peptide bioactivity predictors

1. Raul Fernandez-Diaz
2. Rodrigo Cossio-Pérez
3. Clement Agoni
4. Hoang Thanh Lam
5. Vanessa Lopez
6. Denis C. Shields

Reviewed by Arcadia Science

TRESK background potassium channel in MrgprA3 ⁺ pruriceptors regulates acute and chronic itch

1. Júlia Llimós-Aubach
2. Alba Andres-Bilbe
3. Anna Pujol-Coma
4. Irene Pallás
5. Josep Maria de Anta
6. Concepció Soler
7. Núria Comes
8. Gerard Callejo
9. Xavier Gasull

Reviewed by Arcadia Science

All three MutL complexes are required for repeat expansion in a human stem cell model of CAG-repeat expansion mediated glutaminase deficiency

1. Bruce Hayward
2. Daman Kumari
3. Clara D.M. van Karnebeek
4. André B.P. van Kuilenburg
5. Karen Usdin

Reviewed by Arcadia Science

Mantis: high-throughput 4D imaging and analysis of the molecular and physical architecture of cells

1. Ivan E. Ivanov
2. Eduardo Hirata-Miyasaki
3. Talon Chandler
4. Rasmi Cheloor Kovilakam
5. Ziwen Liu
6. Chad Liu
7. Manuel D. Leonetti
8. Bo Huang
9. Shalin B. Mehta

Reviewed by Arcadia Science

Classification of bioactive peptides: a comparative analysis of models and encodings

1. Edoardo Bizzotto
2. Guido Zampieri
3. Laura Treu
4. Pasquale Filannino
5. Raffaella Di Cagno
6. Stefano Campanaro

Reviewed by Arcadia Science

Biophysical mechanism of ultrafast helical twisting contraction in the giant unicellular ciliate Spirostomum ambiguum

1. L. X. Xu
2. M. S. Bhamla

Reviewed by Arcadia Science

Multistability driven by cooperative growth in microbial communities

1. William Lopes
2. Daniel R. Amor
3. Jeff Gore

Reviewed by Arcadia Science

Disease-associated astrocyte epigenetic memory promotes CNS pathology

1. Hong-Gyun Lee
2. Joseph M. Rone
3. Zhaorong Li
4. Camilo Faust Akl
5. Seung Won Shin
6. Joon-Hyuk Lee
7. Lucas E. Flausino
8. Florian Pernin
9. Chun-Cheih Chao
10. Kilian L. Kleemann
11. Lena Srun
12. Tomer Illouz
13. Federico Giovannoni
14. Marc Charabati
15. Liliana M. Sanmarco
16. Jessica E. Kenison
17. Gavin Piester
18. Stephanie E. J. Zandee
19. Jack Antel
20. Veit Rothhammer
21. Michael A. Wheeler
22. Alexandre Prat
23. Iain C. Clark
24. Francisco J. Quintana

Reviewed by Arcadia Science

Sweet and fatty symbionts: photosynthetic productivity and carbon storage boosted in microalgae within a host

1. A. Catacora-Grundy
2. F. Chevalier
3. D. Yee
4. C. LeKieffre
5. N. L. Schieber
6. Y. Schwab
7. B. Gallet
8. P.H. Jouneau
9. G. Curien
10. J. Decelle

Reviewed by Arcadia Science

Comparative Hox genes expression within the dimorphic annelid Streblospio benedicti reveals patterning variation during development

1. Jose Maria Aguilar-Camacho
2. Nathan D. Harry
3. Christina Zakas

Reviewed by Arcadia Science

BioLLMBench: A Comprehensive Benchmarking of Large Language Models in Bioinformatics

1. Varuni Sarwal
2. Viorel Munteanu
3. Timur Suhodolschi
4. Dumitru Ciorba
5. Eleazar Eskin
6. Wei Wang
7. Serghei Mangul

Reviewed by Arcadia Science