Evaluated articles

Mast cells promote pathology and susceptibility in tuberculosis

1. Ananya Gupta
2. Vibha Taneja
3. Javier Rangel-Moreno
4. Nilofer Naqvi
5. Abhimanyu
6. Yun Tao
7. Mushtaq Ahmed
8. Kuldeep Singh Chauhan
9. Daniela Trejo-Ponce de Leon
10. Gustavo Ramírez-Martínez
11. Luis Jiménez-Alvarez
12. Cesar Luna-Rivero
13. Joaquin Zuniga
14. Deepak Kaushal
15. Shabaana A Khader

• Curated by eLife

  eLife Assessment

  In this useful study, the authors utilize published scRNA-seq data to highlight the potential importance of mast cells (MCs) in TB granulomas, presenting a solid comparative assessment of chymase- and tryptase-expressing MCs in the lungs of Mycobacterium tuberculosis-infected individuals and non-human primates. While the authors appropriately discussed the inconsistencies across models, adoptive transfer experiments in MC-deficient mice would substantially strengthen the causal link between MCs and TB outcomes, providing more direct functional validation of the proposed role of MCs in TB pathogenesis.

Reviewed by eLife, Arcadia Science

Population genomics reveals strong impacts of genetic drift without purging and guides conservation of bull and giant kelp

1. Jordan B. Bemmels
2. Samuel Starko
3. Brooke L. Weigel
4. Kaede Hirabayashi
5. Alex Pinch
6. Cassandra Elphinstone
7. Megan N. Dethier
8. Loren H. Rieseberg
9. Jonathan E. Page
10. Christopher J. Neufeld
11. Gregory L. Owens

Reviewed by Arcadia Science

Cigarette smoke impairs the endocytotic process in Saccharomyces cerevisiae

1. Aditya Shukla
2. Srimonti Sarkar
3. Alok Kumar Sil

Reviewed by Arcadia Science

BFVD—a large repository of predicted viral protein structures

1. Rachel Seongeun Kim
2. Eli Levy Karin
3. Milot Mirdita
4. Rayan Chikhi
5. Martin Steinegger

Reviewed by Arcadia Science

Mechanical Centrosome Fracturing during Cell Navigation

1. Madeleine T. Schmitt
2. Mauricio J.A. Ruiz-Fernandez
3. Kasia Stefanowski
4. Janina Kroll
5. Robert Hauschild
6. Jack Merrin
7. Thomas Penz
8. Eva Kiermaier
9. Christoph Bock
10. Tobias Straub
11. Jörg Renkawitz

Reviewed by Arcadia Science

An automated microfluidic platform for toxicity testing based on Caenorhabditis elegans

1. Jiaying Wu
2. Jing Xi
3. Zhouhai Zhu
4. Wei Zhao
5. Qiyuan Peng
6. Chunbo Liu
7. Ziqian Wan
8. Yiyi Cao
9. Xiang Chen
10. Yang Luan

Reviewed by Arcadia Science

Reduced gravity and muon flux absence affect Caenorhabditis elegans life history traits and viral infection

1. Ana Villena-Giménez
2. Victoria G. Castiglioni
3. Juan C. Muñoz-Sánchez
4. Esmeralda G. Legarda
5. Rubén González
6. Santiago F. Elena

Reviewed by Arcadia Science

Intestinal helminth skews DC2 development towards regulatory phenotype to counter the anti-helminth immune response

1. Anna Andrusaite
2. Olivia Ridgewell
3. Anna Ahlback
4. Holly Webster
5. Hiroki Yamaguchi
6. Molly Peel
7. Annika Frede
8. Sarwah Al-Khalidi
9. Andrew Farthing
10. Anna Heawood
11. Annabelle Smith
12. Edward Roberts
13. Allan Mowat
14. Richard Maizels
15. Georgia Perona-Wright
16. Simon Milling

Reviewed by Arcadia Science

Dimensionality reduction of genetic data using contrastive learning

1. Filip Thor
2. Carl Nettelblad

Reviewed by Arcadia Science

Evolutionary trends in the emergence of skeletal cell types

1. Amor Damatac
2. Sara Koska
3. Kristian K Ullrich
4. Tomislav Domazet-Lošo
5. Alexander Klimovich
6. Markéta Kaucká

Reviewed by Arcadia Science

Quantitative Comparison of Monomeric StayGold Variants Using Protein Nanocages in Living Cells

1. Giulia Viola
2. Kyle A. Jacobs
3. Joël Lemière
4. Matthew L. Kutys
5. Torsten Wittmann

Reviewed by Arcadia Science

A novel channel invariant architecture for the segmentation of cells and nuclei in multiplexed images using InstanSeg

1. Thibaut Goldsborough
2. Alan O’Callaghan
3. Fiona Inglis
4. Léo Leplat
5. Andrew Filby
6. Hakan Bilen
7. Peter Bankhead

Reviewed by Arcadia Science

Functional Diversification of Gene Duplicates under the Constraint of Protein Structure

1. Kangning Guo
2. Yuqing Yang
3. Tingting You
4. Kangli Zhu

Reviewed by Arcadia Science

Opening the species box: what parsimonious microscopic models of speciation have to say about macroevolution

1. Élisa Couvert
2. François Bienvenu
3. Jean-Jil Duchamps
4. Adélie Erard
5. Verónica Miró Pina
6. Emmanuel Schertzer
7. Amaury Lambert

Reviewed by Arcadia Science

Exploring breast cancer-related biochemical changes in circulating extracellular vesicles using Raman spectroscopy

1. Arianna Bonizzi
2. Lorena Signati
3. Maria Grimaldi
4. Marta Truffi
5. Francesca Piccotti
6. Stella Gagliardi
7. Giulia Dotti
8. Serena Mazzucchelli
9. Sara Albasini
10. Roberta Cazzola
11. Debanjan Bhowmik
12. Chandrabhas Narayana
13. Fabio Corsi
14. Carlo Morasso

Reviewed by Arcadia Science

Morphology-based classification of sickle cell disease and β-thalassemia using a low-cost automated microscope and machine learning

1. Pranav Shrestha
2. Hendrik Lohse
3. Christopher Bhatla
4. Heather McCartney
5. Alaa Alzaki
6. Navdeep Sandhu
7. Pradip Kumar Oli
8. Hongquan Li
9. Manu Prakash
10. Ali Amid
11. Rodrigo Onell
12. Nicholas Au
13. Hayley Merkeley
14. Videsh Kapoor
15. Rajan Pande
16. Boris Stoeber

Reviewed by Arcadia Science

Host transcriptional signatures associated with disease tolerance and environmental persistence in a mosquito–microsporidian system

1. Luís M. Silva

Reviewed by Arcadia Science

Molecular Insights into Single-Chain Lipid Modulation of Acid-Sensing Ion Channel 3

1. Ramya Bandarupalli
2. Rebecca Roth
3. Robert C Klipp
4. John R Bankston
5. Jing Li

Reviewed by Arcadia Science

Two mechanisms of photoenergy regulation revealed by kinetic behaviors of chlorophyll fluorescence during light adaptation

1. Junqing Chen
2. Lijiang Fu
3. Ya Guo
4. Jinglu Tan

Reviewed by Arcadia Science

Distinct bacterial and protist plankton diversity dynamics uncovered through DNA-based monitoring in the Baltic Sea area

1. Krzysztof T Jurdzinski
2. Meike AC Latz
3. Anders Torstensson
4. Sonia Brugel
5. Mikael Hedblom
6. Yue O O Hu
7. Markus Lindh
8. Agneta Andersson
9. Bengt Karlson
10. Anders F Andersson

Reviewed by Arcadia Science