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  1. Atlas of Plasmodium falciparum intraerythrocytic development using expansion microscopy

    This article has 9 authors:
    1. Benjamin Liffner
    2. Ana Karla Cepeda Diaz
    3. James Blauwkamp
    4. David Anaguano
    5. Sonja Frolich
    6. Vasant Muralidharan
    7. Danny W Wilson
    8. Jeffrey D Dvorin
    9. Sabrina Absalon
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study provides an unprecedented overview of the subcellular organization of proliferative blood stage malaria parasites using expansion microscopy. The localization of multiple parasite organelles is comprehensively probed using three-dimensional super-resolution microscopy throughout the entire intraerythrocytic development cycle. This work provides a compelling framework to investigate in future more deeply the unconventional cell biology of malaria-causing parasites.

    Reviewed by eLife, preLights, Life Science Editors

    This article has 11 evaluationsAppears in 6 listsLatest version Latest activity

    Paul Shannon

    A number of revisions, a number of groups providing expert opinion and now a link at the top of the timeline to the eLife Reviewed Preprint.

  2. lncRNA H19/Let7b/EZH2 axis regulates somatic cell senescence

    This article has 5 authors:
    1. Manali Potnis
    2. Justin Do
    3. Olivia El Naggar
    4. Eishi Noguchi
    5. Christian Sell
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this manuscript, Sell et al., investigate the role of the long non-coding RNA H19 in regulating cellular senescence. Using several cell models they identify upstream and downstream effectors of H19 including let-7 and EZH2. The advances in this work include the identification of a specific cascade of factors connecting H19, senescence and the actions of rapamycin.

    Reviewed by eLife, ASAPbio crowd review

    This article has 4 evaluationsAppears in 5 listsLatest version Latest activity

    Paul Shannon

    ASAPbio's Crowd Review group first picked this paper up and it was later submitted to eLife where further peer review resulted in the eLife assessment and creation of a Reviewed Preprint at eLife. Another example of more than one group sharing their expertise about a paper.

  3. Dynamic allosteric networks drive adenosine A1 receptor activation and G-protein coupling

    This article has 2 authors:
    1. Miguel A Maria-Solano
    2. Sun Choi
    This article has been curated by 2 groups:
    • Curated by eLife

      eLife assessment

      The authors describe the dynamics underlying allostery of the adenosine A1 receptor, providing valuable insights into the receptor's activation pathway. The enhanced sampling molecular dynamics simulations of available structural data, followed by network analysis, reveal transient conformational states and communication between functional regions. The authors carefully state the limitations of their work, including the restricted convergence of the free energy landscape and missing water-mediated hydrogen bond coordination. Collectively, they provide a convincing framework for advancing rational design strategies of specific modulators with desired modes of action.

      [Editors' note: this was originally reviewed and assessed by Biophysics Colab]

    • Curated by Biophysics Colab

      Evaluation statement (16 June 2023)

      Maria-Solano and Choi present the dynamics underlying allostery of the adenosine A1 receptor, providing valuable insights into the receptor's activation pathway. The enhanced sampling molecular dynamics simulations of available structural data, followed by network analysis, reveal transient conformational states and communication between functional regions. The authors carefully state the limitations of their work, including the restricted convergence of the free energy landscape and missing water-mediated hydrogen bond coordination. Collectively, the findings provide a convincing framework to advance rational design strategies of specific modulators with desired modes of action.

      Biophysics Colab considers this to be a convincing study and recommends it to scientists interested in the structural dynamics, allosteric pathway activations, and free energy landscapes of GPCRs.

      (This evaluation by Biophysics Colab refers to version 5 of this preprint, which has been revised in response to peer review of versions 3 and 4.)

    Reviewed by eLife, Biophysics Colab

    This article has 5 evaluationsAppears in 7 listsLatest version Latest activity

    Paul Shannon

    Two of the first groups to embrace the PRC publishing model have curated this preprint with their own distinct method of providing a "curation statement". The paper was originally reviewed and assessed by Biophysics Colab before it was submitted to eLife where that information was taken to provide further review and assessment. A great example of more than one reviewing organisation collaborating to provide a broader range of expertise and views.

  4. Atlas of Plasmodium falciparum intraerythrocytic development using expansion microscopy

    This article has 9 authors:
    1. Benjamin Liffner
    2. Ana Karla Cepeda Diaz
    3. James Blauwkamp
    4. David Anaguano
    5. Sonja Frolich
    6. Vasant Muralidharan
    7. Danny W Wilson
    8. Jeffrey D Dvorin
    9. Sabrina Absalon
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study provides an unprecedented overview of the subcellular organization of proliferative blood stage malaria parasites using expansion microscopy. The localization of multiple parasite organelles is comprehensively probed using three-dimensional super-resolution microscopy throughout the entire intraerythrocytic development cycle. This work provides a compelling framework to investigate in future more deeply the unconventional cell biology of malaria-causing parasites.

    Reviewed by eLife, preLights, Life Science Editors

    This article has 11 evaluationsAppears in 6 listsLatest version Latest activity

    Paul Shannon

    Three groups have shared opinions and expertise on this preprint - first reviewed by Life Science Editors, then later reviewed by 3 reviewers at eLife with as resulting eLife assessment, before it was also highlighted on prelights. A good example of the breadth and diversity of approach to curation, highlighting and review that you can see on Sciety.

  5. DNMT3B PWWP mutations cause hypermethylation of heterochromatin

    This article has 19 authors:
    1. Francesca Taglini
    2. Ioannis Kafetzopoulos
    3. Willow Rolls
    4. Kamila Irena Musialik
    5. Heng Yang Lee
    6. Yujie Zhang
    7. Mattia Marenda
    8. Lyndsay Kerr
    9. Hannah Finan
    10. Cristina Rubio-Ramon
    11. Philippe Gautier
    12. Hannah Wapenaar
    13. Dhananjay Kumar
    14. Hazel Davidson-Smith
    15. Jimi Wills
    16. Laura C Murphy
    17. Ann Wheeler
    18. Marcus D Wilson
    19. Duncan Sproul

    Reviewed by Review Commons, PREreview

    This article has 6 evaluationsAppears in 4 listsLatest version Latest activity

    Paul Shannon

    A neat example of two reviewing groups covering the same paper with PREreview and Review Commons involved.

  6. Recommendations for accelerating open preprint peer review to improve the culture of science

    This article has 53 authors:
    1. Michele Avissar-Whiting
    2. Frédérique Belliard
    3. Stefano M. Bertozzi
    4. Amy Brand
    5. Katherine Brown
    6. Géraldine Clément-Stoneham
    7. Stephanie Dawson
    8. Gautam Dey
    9. Daniel Ecer
    10. Scott C. Edmunds
    11. Ashley Farley
    12. Tara D. Fischer
    13. Maryrose Franko
    14. James S. Fraser
    15. Kathryn Funk
    16. Clarisse Ganier
    17. Melissa Harrison
    18. Anna Hatch
    19. Haley Hazlett
    20. Samantha Hindle
    21. Daniel W. Hook
    22. Phil Hurst
    23. Sophien Kamoun
    24. Robert Kiley
    25. Michael M. Lacy
    26. Marcel LaFlamme
    27. Rebecca Lawrence
    28. Thomas Lemberger
    29. Maria Leptin
    30. Elliott Lumb
    31. Catriona J. MacCallum
    32. Christopher Steven Marcum
    33. Gabriele Marinello
    34. Alex Mendonça
    35. Sara Monaco
    36. Kleber Neves
    37. Damian Pattinson
    38. Jessica K. Polka
    39. Iratxe Puebla
    40. Martyn Rittman
    41. Stephen J. Royle
    42. Daniela Saderi
    43. Richard Sever
    44. Kathleen Shearer
    45. John E. Spiro
    46. Bodo Stern
    47. Dario Taraborelli
    48. Ron Vale
    49. Claudia G. Vasquez
    50. Ludo Waltman
    51. Fiona M. Watt
    52. Zara Y. Weinberg
    53. Mark Williams
    This article has no evaluationsAppears in 5 listsLatest version

    Paul Shannon

    If you look very closely at the author list, you'll notice Sciety's very own Product Manager, Mark, in the list. This is an exciting preprint as it's about the world that Sciety focuses on - the world of peer-reviewed and curated preprints. It uses data from Sciety to illustrate points too. As a result of it's significance to Sciety you'll also notice it appears in lots of different lists already.

  7. BNT162b2 Vaccine‐Associated Myo/Pericarditis in Adolescents: A Stratified Risk‐Benefit Analysis

    This article has 3 authors:
    1. Allison Krug
    2. Josh Stevenson
    3. Tracy Beth Høeg

    Reviewed by NCRC, ScreenIT

    This article has 2 evaluationsAppears in 5 listsLatest version Latest activity

    Paul Shannon

    This paper was getting a lot of attention when we were all amid COVID-19 pandemic chaos. We enabled NCRC to showcase their take on it coupled with the ScreenIT scan of the content. While Sciety has grown in many respects since then, this earlier example of the impact it had on the world's pandemic response is worthy of any list highlighting the significance of preprint review.

  8. Transferred mitochondria accumulate reactive oxygen species, promoting proliferation

    This article has 14 authors:
    1. Chelsea U Kidwell
    2. Joseph R Casalini
    3. Soorya Pradeep
    4. Sandra D Scherer
    5. Daniel Greiner
    6. Defne Bayik
    7. Dionysios C Watson
    8. Gregory S Olson
    9. Justin D Lathia
    10. Jarrod S Johnson
    11. Jared Rutter
    12. Alana L Welm
    13. Thomas A Zangle
    14. Minna Roh-Johnson
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This manuscript provides compelling evidence that macrophages transfer mitochondria to cancer cells and that transferred mitochondria stimulate proliferation in recipient cells. The usage an array of clever cell biology-based tools provides compelling evidence for these claims despite the difficulties associated with studying a relatively low probability event. Solid evidence supports the proposed model that transferred mitochondria induce proliferation by stimulating ERK signaling in a ROS dependent manner, although at present some aspects of the proposed model are incomplete. The work has broad significance for both mitochondrial biology and cancer biology as the authors show clear evidence of mitochondrial transfer in mouse models of human tumors.

    Reviewed by eLife, ASAPbio crowd review

    This article has 6 evaluationsAppears in 6 listsLatest version Latest activity
  9. Inhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial

    This article has 24 authors:
    1. Sanjay Ramakrishnan
    2. Dan V Nicolau
    3. Beverly Langford
    4. Mahdi Mahdi
    5. Helen Jeffers
    6. Christine Mwasuku
    7. Karolina Krassowska
    8. Robin Fox
    9. Ian Binnian
    10. Victoria Glover
    11. Stephen Bright
    12. Christopher Butler
    13. Jennifer L Cane
    14. Andreas Halner
    15. Philippa C Matthews
    16. Louise E Donnelly
    17. Jodie L Simpson
    18. Jonathan R Baker
    19. Nabil T Fadai
    20. Stefan Peterson
    21. Thomas Bengtsson
    22. Peter J Barnes
    23. Richard E K Russell
    24. Mona Bafadhel

    Reviewed by Rapid Reviews Infectious Diseases, PREreview, ScreenIT

    This article has 5 evaluationsAppears in 6 listsLatest version Latest activity
  10. Evidence for increased breakthrough rates of SARS-CoV-2 variants of concern in BNT162b2-mRNA-vaccinated individuals

    This article has 29 authors:
    1. Talia Kustin
    2. Noam Harel
    3. Uriah Finkel
    4. Shay Perchik
    5. Sheri Harari
    6. Maayan Tahor
    7. Itamar Caspi
    8. Rachel Levy
    9. Michael Leshchinsky
    10. Shifra Ken Dror
    11. Galit Bergerzon
    12. Hala Gadban
    13. Faten Gadban
    14. Eti Eliassian
    15. Orit Shimron
    16. Loulou Saleh
    17. Haim Ben-Zvi
    18. Elena Keren Taraday
    19. Doron Amichay
    20. Anat Ben-Dor
    21. Dana Sagas
    22. Merav Strauss
    23. Yonat Shemer Avni
    24. Amit Huppert
    25. Eldad Kepten
    26. Ran D. Balicer
    27. Doron Netzer
    28. Shay Ben-Shachar
    29. Adi Stern

    Reviewed by NCRC, Rapid Reviews Infectious Diseases, ScreenIT

    This article has 6 evaluationsAppears in 6 listsLatest version Latest activity

    Paul Shannon

    A SARS-CoV-2 pandemic-related paper that saw interest from all three groups on Sciety focused on that research area.

  11. Safety and Efficacy of NVX-CoV2373 Covid-19 Vaccine

    This article has 45 authors:
    1. Paul T. Heath
    2. Eva P. Galiza
    3. David N. Baxter
    4. Marta Boffito
    5. Duncan Browne
    6. Fiona Burns
    7. David R. Chadwick
    8. Rebecca Clark
    9. Catherine Cosgrove
    10. James Galloway
    11. Anna L. Goodman
    12. Amardeep Heer
    13. Andrew Higham
    14. Shalini Iyengar
    15. Arham Jamal
    16. Christopher Jeanes
    17. Philip A. Kalra
    18. Christina Kyriakidou
    19. Daniel F. McAuley
    20. Agnieszka Meyrick
    21. Angela M. Minassian
    22. Jane Minton
    23. Patrick Moore
    24. Imrozia Munsoor
    25. Helen Nicholls
    26. Orod Osanlou
    27. Jonathan Packham
    28. Carol H. Pretswell
    29. Alberto San Francisco Ramos
    30. Dinesh Saralaya
    31. Ray P. Sheridan
    32. Richard Smith
    33. Roy L. Soiza
    34. Pauline A. Swift
    35. Emma C. Thomson
    36. Jeremy Turner
    37. Marianne E. Viljoen
    38. Gary Albert
    39. Iksung Cho
    40. Filip Dubovsky
    41. Greg Glenn
    42. Joy Rivers
    43. Andreana Robertson
    44. Kathy Smith
    45. Seth Toback

    Reviewed by NCRC, ScreenIT

    This article has 2 evaluationsAppears in 4 listsLatest version Latest activity
  12. Heritable functional architecture in human visual cortex

    This article has 6 authors:
    1. Ivan Alvarez
    2. Nonie J. Finlayson
    3. Shwe Ei
    4. Benjamin de Haas
    5. John A. Greenwood
    6. D. Samuel Schwarzkopf
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      The paper was viewed as generally sound. There main concern was that the findings were viewed as incremental without a demonstration of a link between the heritability of pRF properties and visual perception. The speculation in the Discussion about shared perceptual experience is intriguing, but psychophysical (or other) evidence would be needed to really make that point clearly. In addition, there was some discussion about the non-independence of vertices and correlation values. In the end, we all agreed that non-independent vertices may inflate correlation coefficient values, but that this is unlikely to substantially affect conclusions drawn from comparisons of monozygotic and dizygotic twins.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife

    This article has 3 evaluationsAppears in 4 listsLatest version Latest activity
  13. Household COVID-19 risk and in-person schooling

    This article has 8 authors:
    1. Justin Lessler
    2. M. Kate Grabowski
    3. Kyra H. Grantz
    4. Elena Badillo-Goicoechea
    5. C. Jessica E. Metcalf
    6. Carly Lupton-Smith
    7. Andrew S. Azman
    8. Elizabeth A. Stuart

    Reviewed by NCRC, ScreenIT

    This article has 2 evaluationsAppears in 4 listsLatest version Latest activity

    Paul Shannon

    One of NCRC's "High interest" articles, this preprint had a lot of attention at the time it was posted so having their review of the article appear within a month of first being posted was significant.

  14. A novel SARS-CoV-2 related coronavirus in bats from Cambodia

    This article has 16 authors:
    1. Vibol Hul
    2. Deborah Delaune
    3. Erik A Karlsson
    4. Alexandre Hassanin
    5. Putita Ou Tey
    6. Artem Baidaliuk
    7. Fabiana Gámbaro
    8. Vuong Tan Tu
    9. Lucy Keatts
    10. Jonna Mazet
    11. Christine Johnson
    12. Philippe Buchy
    13. Philippe Dussart
    14. Tracey Goldstein
    15. Etienne Simon-Lorière
    16. Veasna Duong

    Reviewed by ScreenIT, NCRC

    This article has 2 evaluationsAppears in 3 listsLatest version Latest activity
  15. Insulin-producing β-cells regenerate ectopically from a mesodermal origin under the perturbation of hemato-endothelial specification

    This article has 11 authors:
    1. Ka-Cheuk Liu
    2. Alethia Villasenor
    3. Maria Bertuzzi
    4. Nicole Schmitner
    5. Niki Radros
    6. Linn Rautio
    7. Kenny Mattonet
    8. Ryota L Matsuoka
    9. Sven Reischauer
    10. Didier YR Stainier
    11. Olov Andersson
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      This is an elegant study demonstrating the emergence of mesoderm-derived beta-like cells following beta-cell ablation in an endothelial cell deficient context. These findings will be of interest to scientists in the areas of regeneration and reprogramming, as they reveal a previously unknown degree of germ layer plasticity in the embryo. In the long term the study has potential impact in the diabetes field, as it reveals a novel path for redirecting somatic cells into insulin-producing cells in an in vivo context.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their names with the authors.)

    Reviewed by eLife

    This article has 2 evaluationsAppears in 3 listsLatest version Latest activity