Evaluated articles

A list by preLights

Articles that have been evaluated by preLights.

1420 articlesLast updated

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  5. HIF1A-mediated pathways promote euploid cell survival in chromosomally mosaic embryos

    1. Estefania Sanchez-Vasquez
    2. Marianne E Bronner
    3. Magdalena Zernicka-Goetz

    • Curated by eLife

      eLife Assessment

      Sanchez-Vasquez et al establish an innovative approach to induce aneuploidy in preimplantation embryos. This important study extends the author's previous publications evaluating the consequences of aneuploidy in the mammalian embryo. In this work, the authors investigate the developmental potential of aneuploid embryos and characterize changes in gene expression profiles under normoxic and hypoxic culture conditions. Using a solid methodology they identify sensitivity to Hif1alpha loss in aneuploid embryos, and in further convincing experiments they assess how levels of DNA damage and DNA repair are altered under hypoxic and normoxic conditions.

    Reviewed by eLife, preLights

    11 evaluationsAppears in 2 listsLatest version Latest activity

  6. Global coordination of protrusive forces in migrating immune cells

    1. Patricia Reis-Rodrigues
    2. Nikola Canigova
    3. Mario J. Avellaneda
    4. Florian Gaertner
    5. Kari Vaahtomeri
    6. Michael Riedl
    7. Jack Merrin
    8. Robert Hauschild
    9. Yoshinori Fukui
    10. Alba Juanes Garcia
    11. Michael Sixt

    Reviewed by preLights

    1 evaluationAppears in 1 listLatest version Latest activity

  10. Integrin conformation-dependent neutrophil slowing obstructs the capillaries of the pre-metastatic lung in a model of breast cancer

    1. Frédéric Fercoq
    2. Gemma S. Cairns
    3. Marco De Donatis
    4. John B. G. Mackey
    5. Alessia Floerchinger
    6. Amanda McFarlane
    7. Ximena L. Raffo-Iraolagoitia
    8. Declan Whyte
    9. Lindsey W. G. Arnott
    10. Colin Nixon
    11. Robert Wiesheu
    12. Anna Kilbey
    13. Leah Brown
    14. Sarwah Al-Khalidi
    15. Jim C. Norman
    16. Edward W. Roberts
    17. Karen Blyth
    18. Seth B. Coffelt
    19. Leo M. Carlin

    Reviewed by preLights

    1 evaluationAppears in 1 listLatest version Latest activity

  14. Engineered Nanotopographies Induce Transient Openings in the Nuclear Membrane

    1. Einollah Sarikhani
    2. Vrund Patel
    3. Zhi Li
    4. Dhivya Pushpa Meganathan
    5. Keivan Rahmani
    6. Leah Sadr
    7. Ryan Hosseini
    8. Diether Visda
    9. Shivani Shukla
    10. Hamed Naghsh‐Nilchi
    11. Adarsh Balaji
    12. Gillian McMahon
    13. Shaoming Chen
    14. Johannes Schöneberg
    15. Colleen A. McHugh
    16. Lingyan Shi
    17. Zeinab Jahed

    Reviewed by preLights

    1 evaluationAppears in 1 listLatest version Latest activity

  15. Pharyngeal neuronal mechanisms governing sour taste perception in Drosophila melanogaster

    1. Bhanu Shrestha
    2. Jiun Sang
    3. Suman Rimal
    4. Youngseok Lee

    • Curated by eLife

      eLife Assessment

      This is a useful contribution to our understanding of taste perception. The idea that specific receptors function in the pharynx to mediate responses to carboxylic acids is interesting, although the expression analysis is incomplete. Reviewers also have a number of other suggestions for improvement, including the request that authors provide more details about the methodology used. In general, the claims are supported by solid evidence and add to a growing body of literature on this topic.

    Reviewed by eLife, preLights

    6 evaluationsAppears in 2 listsLatest version Latest activity

  19. Spiral-eyes: A soft active matter model of in vivo corneal epithelial cell migration

    1. Kaja Kostanjevec
    2. Rastko Sknepnek
    3. Jon Martin Collinson
    4. Silke Henkes

    • Curated by eLife

      eLife Assessment

      This useful study describes a physical mechanism for the emergence of spiral patterns in the outer epithelial layer of the mammalian cornea independent of pre-patterning or guidance cues, using an agent-based model of self-propelled particles with alignment. The model is well constructed, however the central premise of the manuscript, that the spiral patterning of epithelial corneal cells occurs without guidance cues, is incomplete and not fully supported. Several significant questions remain unanswered, such as the role of the corneal curvature or the importance of topological defects. Furthermore, comparison between the model and data are qualitative at best for the moment.

    Reviewed by eLife, preLights

    5 evaluationsAppears in 2 listsLatest version Latest activity
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