Evaluated articles

Discovery and Validation of Context-Dependent Synthetic Mammalian Promoters

1. Adam M. Zahm
2. William S. Owens
3. Samuel R. Himes
4. Kathleen E. Rondem
5. Braden S. Fallon
6. Alexa N. Gormick
7. Joshua S. Bloom
8. Sriram Kosuri
9. Henry Chan
10. Justin G. English

Reviewed by preLights

Planarians employ diverse and dynamic stem cell microenvironments to support whole-body regeneration

1. Blair W. Benham-Pyle
2. Frederick G. Mann
3. Carolyn E. Brewster
4. Enya R. Dewars
5. Dung M. Vuu
6. Stephanie H. Nowotarski
7. Carlos Guerrero-Hernández
8. Seth Malloy
9. Kate E. Hall
10. Lucinda E. Maddera
11. Shiyuan Chen
12. Jason A. Morrison
13. Sean A. McKinney
14. Brian D. Slaughter
15. Anoja Perera
16. Alejandro Sánchez Alvarado

Reviewed by preLights

Caveola mechanotransduction reinforces the cortical cytoskeleton to promote epithelial resilience

1. John W. Brooks
2. Vikas Tillu
3. Julia Eckert
4. Suzie Verma
5. Brett M. Collins
6. Robert G. Parton
7. Alpha S. Yap

Reviewed by preLights

Atlas of Plasmodium falciparum intraerythrocytic development using expansion microscopy

1. Benjamin Liffner
2. Ana Karla Cepeda Diaz
3. James Blauwkamp
4. David Anaguano
5. Sonja Frolich
6. Vasant Muralidharan
7. Danny W Wilson
8. Jeffrey D Dvorin
9. Sabrina Absalon

• Curated by eLife

  eLife assessment

  This important study provides an unprecedented overview of the subcellular organization of proliferative blood stage malaria parasites using expansion microscopy. The localization of multiple parasite organelles is comprehensively probed using three-dimensional super-resolution microscopy throughout the entire intraerythrocytic development cycle. This work provides a compelling framework to investigate in future more deeply the unconventional cell biology of malaria-causing parasites.

Reviewed by eLife, preLights, Life Science Editors

Glioblastoma extracellular vesicles influence glial cell hyaluronic acid deposition to promote invasiveness

1. Dominik Koessinger
2. David Novo
3. Anna Koessinger
4. America Campos
5. Jasmine Peters
6. Louise Dutton
7. Peggy Paschke
8. Désirée Zerbst
9. Madeleine Moore
10. Louise Mitchell
11. Matthew Neilson
12. Katrina Stevenson
13. Anthony Chalmers
14. Stephen Tait
15. Joanna Birch
16. Jim Norman

Reviewed by preLights

DNA methylation rates scale with maximum lifespan across mammals

1. Samuel J. C. Crofts
2. Eric Latorre-Crespo
3. Tamir Chandra

Reviewed by preLights

Polθ is phosphorylated by Polo-like kinase 1 (PLK1) to enable repair of DNA double strand breaks in mitosis

1. Camille Gelot
2. Marton Tibor Kovacs
3. Simona Miron
4. Emilie Mylne
5. Rania Ghouil
6. Tatiana Popova
7. Florent Dingli
8. Damarys Loew
9. Josée Guirouilh-Barbat
10. Elaine Del Nery
11. Sophie Zinn-Justin
12. Raphael Ceccaldi

Reviewed by preLights

Biologically informed NeuralODEs for genome-wide regulatory dynamics

1. Intekhab Hossain
2. Viola Fanfani
3. Jonas Fischer
4. John Quackenbush
5. Rebekka Burkholz

Reviewed by preLights

Interspecies blastocyst complementation generates functional rat cell-derived forebrain tissues in mice

1. Jia Huang
2. Bingbing He
3. Xiali Yang
4. Xin Long
5. Yinghui Wei
6. Yanxia Gao
7. Yuan Fang
8. Wenqin Ying
9. Zikang Wang
10. Chao Li
11. Yingsi Zhou
12. Shuaishuai Li
13. Linyu Shi
14. Fan Guo
15. Haibo Zhou
16. Hui Yang
17. Jun Wu

Reviewed by preLights

Insights from a survey of mentorship experiences by graduate and postdoctoral researchers

1. Sarvenaz Sarabipour
2. Natalie M Niemi
3. Steven J Burgess
4. Christopher T Smith
5. Alexandre W Bisson Filho
6. Ahmed Ibrahim
7. Kelly Clark

Reviewed by preLights

EXO1-mediated DNA repair by single-strand annealing is essential for BRCA1-deficient cells

1. B. van de Kooij
2. A. Schreuder
3. R.S. Pavani
4. V. Garzero
5. A. Van Hoeck
6. M. San Martin Alonso
7. D. Koerse
8. T.J. Wendel
9. E. Callen
10. J. Boom
11. H. Mei
12. E. Cuppen
13. A. Nussenzweig
14. H. van Attikum
15. S.M. Noordermeer

Reviewed by preLights

A single laccase acts as a key component of environmental sensing in a broad host range fungal pathogen

1. Nathaniel M. Westrick
2. Eddie G. Dominguez
3. Madeline Bondy
4. Christina M. Hull
5. Damon L. Smith
6. Mehdi Kabbage

Reviewed by preLights

Susceptible bacteria survive antibiotic treatment in the mammalian gastrointestinal tract without evolving resistance

1. Marinelle Rodrigues
2. Parastoo Sabaeifard
3. Muhammed Sadik Yildiz
4. Laura Coughlin
5. Sara Ahmed
6. Cassie Behrendt
7. Xiaoyu Wang
8. Marguerite Monogue
9. Jiwoong Kim
10. Shuheng Gan
11. Xiaowei Zhan
12. Laura Filkins
13. Noelle S. Williams
14. Lora V. Hooper
15. Andrew Y. Koh
16. Erdal Toprak

Reviewed by preLights

Coxiella burnetii actively blocks IL-17-induced oxidative stress in macrophages

1. Tatiana M. Clemente
2. Leonardo Augusto
3. Rajendra K. Angara
4. Stacey D. Gilk

Reviewed by preLights

The antiviral effects of a MEK1/2 inhibitor promote tumor regression in a preclinical model of human papillomavirus infection-induced tumorigenesis

1. Adrian J. Luna
2. Jesse M. Young
3. Rosa T. Sterk
4. Virginie Bondu
5. Fred A. Schultz
6. Donna F. Kusewitt
7. Huining Kang
8. Michelle A. Ozbun

Reviewed by preLights

A survey of Rare Disease awareness among healthcare professionals and researchers in India

1. Laxmikant Vashishta
2. Purna Bapat
3. Yashodhara Bhattacharya
4. Mohua Chakraborty Choudhury
5. Narendra Chirmule
6. Susan D’Costa
7. Shilpa Jindani
8. Manohar Rao
9. Smritie Sheth

Reviewed by preLights

daf-42 is an evolutionarily young gene essential for dauer development in Caenorhabditis elegans

1. Daisy S. Lim
2. Jun Kim
3. Wonjoo Kim
4. Nari Kim
5. Sang-Hee Lee
6. Daehan Lee
7. Junho Lee

Reviewed by preLights

Complete male-to-female sex reversal in XY mice lacking the miR-17∼92 cluster

1. Alicia Hurtado
2. Irene Mota-Gómez
3. Miguel Lao
4. Francisca M. Real
5. Johanna Jedamzick
6. Miguel Burgos
7. Darío G. Lupiáñez
8. Rafael Jiménez
9. Francisco J. Barrionuevo

Reviewed by preLights

Phosphorylation controls spatial and temporal activities of motor‐PRC1 complexes to complete mitosis

1. Agata Gluszek‐Kustusz
2. Benjamin Craske
3. Thibault Legal
4. Toni McHugh
5. Julie PI Welburn

Reviewed by preLights

SQ3370, the first clinical click chemistry-activated cancer therapeutic, shows safety in humans and translatability across species

1. Sangeetha Srinivasan
2. Nathan A. Yee
3. Michael Zakharian
4. Maša Alečković
5. Amir Mahmoodi
6. Tri-Hung Nguyen
7. José M. Mejía Oneto

Reviewed by preLights