Evaluated articles

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Articles that have been evaluated by preLights.

1433 articlesLast updated

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  10. Stress resets ancestral heritable small RNA responses

    1. Leah Houri-Zeevi
    2. Guy Teichman
    3. Hila Gingold
    4. Oded Rechavi

    • Curated by eLife

      Evaluation Summary:

      In humans, extreme stresses, such as famine, can trigger multi-generational physiological responses through altered metabolism. In C. elegans, environmental stresses, such as heat shock, can similarly promote changes in gene expression and physiology. Here, the authors convincingly show that environmental stress can alter small RNA populations in such a manner that can alter gene expression over multiple generations. The work is beginning to tease out some of the mechanisms by which non-genetic information can regulate descendants biology.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife, preLights

    5 evaluationsAppears in 2 listsLatest version Latest activity

  15. An engineered transcriptional reporter of protein localization identifies regulators of mitochondrial and ER membrane protein trafficking in high-throughput CRISPRi screens

    1. Robert Coukos
    2. David Yao
    3. Mateo I Sanchez
    4. Eric T Strand
    5. Meagan E Olive
    6. Namrata D Udeshi
    7. Jonathan S Weissman
    8. Steven A Carr
    9. Michael C Bassik
    10. Alice Y Ting

    • Curated by eLife

      Evaluation Summary:

      Here authors present a robust, high-throughput and genome-wide strategy to identify genes that influence protein localization in individual subcellular compartments. The results profile subsets of genes that are involved in localization of tail-anchored proteins to mitochondrial and endoplasmic reticulum membranes and identify several unexpected regulators. This new tool is adaptable to studying various types of protein trafficking processes to shed light on their molecular mechanisms.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1, Reviewer #2 and Reviewer #3 agreed to share their names with the authors.)

    Reviewed by eLife, preLights

    6 evaluationsAppears in 2 listsLatest version Latest activity

  17. Cell patterning by secretion-induced plasma membrane flows

    1. Veneta Gerganova
    2. Iker Lamas
    3. David M. Rutkowski
    4. Aleksandar Vještica
    5. Daniela Gallo Castro
    6. Vincent Vincenzetti
    7. Dimitrios Vavylonis
    8. Sophie G Martin

    Reviewed by preLights

    1 evaluationAppears in 1 listLatest version Latest activity

  19. Aberrant replication licensing drives Copy Number Gains across species

    1. Patroula Nathanailidou
    2. Michalis Petropoulos
    3. Styliani Maxouri
    4. Eirini Kasselimi
    5. Ioanna Eleni Symeonidou
    6. Ourania Preza
    7. Iris Spiliopoulou-Sdougkou
    8. Vladimir Beneš
    9. Stavros Taraviras
    10. Zoi Lygerou

    Reviewed by preLights

    1 evaluationAppears in 1 listLatest version Latest activity
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