Conditional Guide RNAs: Programmable Conditional Regulation of CRISPR/Cas Function in Bacterial and Mammalian Cells via Dynamic RNA Nanotechnology

  1. Mikhail H. Hanewich-Hollatz
  2. Zhewei Chen
  3. Lisa M. Hochrein
  4. Jining Huang
  5. Niles A. Pierce

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Abstract

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  1. Version published to 10.1021/acscentsci.9b00340
  2. preLights

    Excerpt

    gRNAs for Cas9 are engineered such that they only get activated upon specific RNA triggers. This could one day open the door to linking signaling pathways with Cas9 function!

  3. Version published to 10.1101/525857v1 on bioRxiv