Evaluated articles

Amyotrophic lateral sclerosis associated mislocalisation of TDP-43 to the cytoplasm causes cortical hyperexcitability and reduced excitatory neurotransmission in the motor cortex

1. MS Dyer
2. KE Lewis
3. AK Walker
4. TC Dickson
5. A Woodhouse
6. CA Blizzard

Reviewed by preLights

Mechanical control of morphogenetic robustness in an inherently challenging environment

1. Emmanuel Martin
2. Sophie Theis
3. Guillaume Gay
4. Bruno Monier
5. Christian Rouvière
6. Magali Suzanne

Reviewed by preLights

Two FtsZ proteins orchestrate archaeal cell division through distinct functions in ring assembly and constriction

1. Yan Liao
2. Solenne Ithurbide
3. Christian Evenhuis
4. Jan Löwe
5. Iain G. Duggin

Reviewed by preLights

Antifungal effects of PC945, a novel inhaled triazole, on Candida albicans -infected immunocompromised mice

1. Yuki Nishimoto
2. Kazuhiro Ito
3. Genki Kimura
4. Kirstie A. Lucas
5. Leah Daly
6. Pete Strong
7. Yasuo Kizawa

Reviewed by preLights

Obesity-driven changes in ECM composition promote local invasion and metastasis of breast tumors

1. Andrew Wishart
2. Yifan Peng
3. Sydney Conner
4. Justinne Guarin
5. Rebecca Crews
6. Jackson Fatherree
7. Andrew S. Greenberg
8. Madeleine J. Oudin

Reviewed by preLights

On-Site Ribosome Remodeling by Locally Synthesized Ribosomal Proteins in Axons

1. Toshiaki Shigeoka
2. Max Koppers
3. Hovy Ho-Wai Wong
4. Julie Qiaojin Lin
5. Roberta Cagnetta
6. Asha Dwivedy
7. Janaina de Freitas Nascimento
8. Francesca W. van Tartwijk
9. Florian Ströhl
10. Jean-Michel Cioni
11. Julia Schaeffer
12. Mark Carrington
13. Clemens F. Kaminski
14. Hosung Jung
15. William A. Harris
16. Christine E. Holt

Reviewed by preLights

Dynamics of Meiotic Sex Chromosome Inactivation and Pachytene Activation in Mice Spermatogenesis

1. Ábel Vértesy
2. Javier Frias-Aldeguer
3. Zeliha Sahin
4. Nicolas Rivron
5. Alexander van Oudenaarden
6. Niels Geijsen

Reviewed by preLights

Cholesterol determines the cytosolic entry and seeded aggregation of tau

1. Benjamin J. Tuck
2. Lauren V.C. Miller
3. Taxiarchis Katsinelos
4. Annabel E. Smith
5. Emma L. Wilson
6. Sophie Keeling
7. Shi Cheng
8. Marina J. Vaysburd
9. Claire Knox
10. Lucy Tredgett
11. Emmanouil Metzakopian
12. Leo C. James
13. William A. McEwan

Reviewed by preLights

Defining totipotency using criteria of increasing stringency

1. Eszter Posfai
2. John Paul Schell
3. Adrian Janiszewski
4. Isidora Rovic
5. Alexander Murray
6. Brian Bradshaw
7. Tine Pardon
8. Mouna El Bakkali
9. Irene Talon
10. Natalie De Geest
11. Pankaj Kumar
12. San Kit To
13. Sophie Petropoulos
14. Andrea Jurisicova
15. Vincent Pasque
16. Fredrik Lanner
17. Janet Rossant

Reviewed by preLights

Molecular and cellular dissection of the OSBP cycle through a fluorescent inhibitor

1. Tiphaine Péresse
2. David Kovacs
3. Mélody Subra
4. Joëlle Bigay
5. Meng-Chen Tsai
6. Joël Polidori
7. Romain Gautier
8. Sandy Desrat
9. Lucile Fleuriot
10. Delphine Debayle
11. Marc Litaudon
12. Van-Cuong Pham
13. Jérôme Bignon
14. Bruno Antonny
15. Fanny Roussi
16. Bruno Mesmin

Reviewed by preLights

SCHENGEN receptor module drives localized ROS production and lignification in plant roots

1. Satoshi Fujita
2. Damien De Bellis
3. Kai H Edel
4. Philipp Köster
5. Tonni Grube Andersen
6. Emanuel Schmid‐Siegert
7. Valérie Dénervaud Tendon
8. Alexandre Pfister
9. Peter Marhavý
10. Robertas Ursache
11. Verónica G Doblas
12. Marie Barberon
13. Jean Daraspe
14. Audrey Creff
15. Gwyneth Ingram
16. Jörg Kudla
17. Niko Geldner

Reviewed by preLights

Immunometabolic hijacking of immune cells by a Pseudomonas aeruginosa quorum-sensing signal

1. Arunava Bandyopadhaya
2. Vijay K Singh
3. Arijit Chakraborty
4. A. Aria Tzika
5. Laurence G Rahme

• Curated by eLife

  Evaluation Summary:

  In a previous study the authors showed that the quorum sensing signal molecule 2-aminoacetophenone (2-AA) produced by Pseudomonas aeruginosa enables persistence in host tissue of this pathogen. They propose that this effect depends on a Warburg-like metabolic reprogramming effect in macrophages.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife, preLights

Large-scale curvature sensing by epithelial monolayers depends on active cell mechanics and nuclear mechanoadaptation

1. Marine Luciano
2. Shi-Lei Xue
3. Winnok H. De Vos
4. Lorena Redondo Morata
5. Mathieu Surin
6. Frank Lafont
7. Edouard Hannezo
8. Sylvain Gabriele

Reviewed by preLights

SARS-CoV-2 infects brain choroid plexus and disrupts the blood-CSF-barrier

1. Laura Pellegrini
2. Anna Albecka
3. Donna L. Mallery
4. Max J. Kellner
5. David Paul
6. Andrew P. Carter
7. Leo C. James
8. Madeline A. Lancaster

Reviewed by ScreenIT, preLights

Resolving the 3D Landscape of Transcription-Linked Mammalian Chromatin Folding

1. Tsung-Han S. Hsieh
2. Claudia Cattoglio
3. Elena Slobodyanyuk
4. Anders S. Hansen
5. Oliver J. Rando
6. Robert Tjian
7. Xavier Darzacq

Reviewed by preLights

Physical constraints on early blastomere packings

1. James Giammona
2. Otger Campàs

Reviewed by preLights

Repurposing of synaptonemal complex proteins for kinetochores in Kinetoplastida

1. Eelco C. Tromer
2. Thomas A. Wemyss
3. Patryk Ludzia
4. Ross F. Waller
5. Bungo Akiyoshi

Reviewed by preLights

Analysis of subcellular transcriptomes by RNA proximity labeling with Halo-seq

1. Krysta L Engel
2. Hei-Yong G Lo
3. Raeann Goering
4. Ying Li
5. Robert C Spitale
6. J Matthew Taliaferro

Reviewed by preLights

TGFβ restricts expansion, survival, and function of T cells within the tuberculous granuloma

1. Benjamin H. Gern
2. Kristin N. Adams
3. Courtney R. Plumlee
4. Caleb R. Stoltzfus
5. Laila Shehata
6. Albanus O. Moguche
7. Kathleen Busman-Sahay
8. Scott G. Hansen
9. Michael K. Axthelm
10. Louis J. Picker
11. Jacob D. Estes
12. Kevin B. Urdahl
13. Michael Y. Gerner

Reviewed by preLights

SCHEEPDOG: programming electric cues to dynamically herd large-scale cell migration

1. Tom J. Zajdel
2. Gawoon Shim
3. Linus Wang
4. Alejandro Rossello-Martinez
5. Daniel J. Cohen

Reviewed by preLights