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  1. Chemogenetics defines a short-chain fatty acid receptor gut–brain axis

    This article has 12 authors:
    1. Natasja Barki
    2. Daniele Bolognini
    3. Ulf Börjesson
    4. Laura Jenkins
    5. John Riddell
    6. David I Hughes
    7. Trond Ulven
    8. Brian D Hudson
    9. Elisabeth Rexen Ulven
    10. Niek Dekker
    11. Andrew B Tobin
    12. Graeme Milligan
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      In this paper the authors study the Rolle of small chain fatty acids receptors FFA2 and FFA3 in the dorsal root ganglia with the goal to define molecularly a gut to brain axis. They identified MOMBA as a compound that binds to FFA2. This paper presents a powerful screening strategy to identify receptor agonists. The main concerns are the specificity of the model, and the functional purpose of this gut to brain axis.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife, preLights

    This article has 5 evaluationsAppears in 2 listsLatest version Latest activity
  2. Ageing-associated myelin dysfunction drives amyloid deposition in mouse models of Alzheimer’s disease

    This article has 23 authors:
    1. Constanze Depp
    2. Ting Sun
    3. Andrew Octavian Sasmita
    4. Lena Spieth
    5. Stefan A. Berghoff
    6. Agnes A. Steixner-Kumar
    7. Swati Subramanian
    8. Wiebke Möbius
    9. Sandra Göbbels
    10. Gesine Saher
    11. Silvia Zampar
    12. Oliver Wirths
    13. Maik Thalmann
    14. Takashi Saito
    15. Takaomi Saido
    16. Dilja Krueger-Burg
    17. Riki Kawaguchi
    18. Michael Willem
    19. Christian Haass
    20. Daniel Geschwind
    21. Hannelore Ehrenreich
    22. Ruth Stassart
    23. Klaus-Armin Nave

    Reviewed by preLights

    This article has 1 evaluationAppears in 2 listsLatest version Latest activity
  3. A transcriptional switch governs fibroblast activation in heart disease

    This article has 25 authors:
    1. Michael Alexanian
    2. Pawel F. Przytycki
    3. Rudi Micheletti
    4. Arun Padmanabhan
    5. Lin Ye
    6. Joshua G. Travers
    7. Barbara Gonzalez-Teran
    8. Ana Catarina Silva
    9. Qiming Duan
    10. Sanjeev S. Ranade
    11. Franco Felix
    12. Ricardo Linares-Saldana
    13. Li Li
    14. Clara Youngna Lee
    15. Nandhini Sadagopan
    16. Angelo Pelonero
    17. Yu Huang
    18. Gaia Andreoletti
    19. Rajan Jain
    20. Timothy A. McKinsey
    21. Michael G. Rosenfeld
    22. Casey A. Gifford
    23. Katherine S. Pollard
    24. Saptarsi M. Haldar
    25. Deepak Srivastava

    Reviewed by preLights

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  4. A unified platform to manage, share, and archive morphological and functional data in insect neuroscience

    This article has 13 authors:
    1. Stanley Heinze
    2. Basil el Jundi
    3. Bente G Berg
    4. Uwe Homberg
    5. Randolf Menzel
    6. Keram Pfeiffer
    7. Ronja Hensgen
    8. Frederick Zittrell
    9. Marie Dacke
    10. Eric Warrant
    11. Gerit Pfuhl
    12. JĂŒrgen Rybak
    13. Kevin Tedore
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      This manuscript will be of interest to insect neuroscientists and broadly to the neuroanatomy community. It presents a new web resource that collects and displays neuron, brain region and species data in user-friendly ways. If taken up by the community, it has the potential to become an important data hub.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife, preLights

    This article has 5 evaluationsAppears in 2 listsLatest version Latest activity