A synthetic mechanogenetic gene circuit for autonomous drug delivery in engineered tissues

  1. Robert J. Nims
  2. Lara Pferdehirt
  3. Noelani B. Ho
  4. Alireza Savadipour
  5. Jeremiah Lorentz
  6. Sima Sohi
  7. Jordan Kassab
  8. Alison K. Ross
  9. Christopher J. O’Conor
  10. Wolfgang B. Liedtke
  11. Bo Zhang
  12. Amy L. McNulty
  13. Farshid Guilak

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Abstract

A mechanogenetic system was developed using a synthetic gene circuit to produce biologic drugs in response to mechanical loading.

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  1. Version published to 10.1126/sciadv.abd9858
  2. Version published to 10.1101/2020.04.29.069294v2 on bioRxiv
  4. Version published to 10.1101/2020.04.29.069294v1 on bioRxiv