Evaluated articles

Genome-wide modeling of DNA replication in space and time confirms the emergence of replication specific patterns in vivo in eukaryotes

1. Dario D’Asaro
2. Jean-Michel Arbona
3. Vinciane Piveteau
4. Aurèle Piazza
5. Cédric Vaillant
6. Daniel Jost

Reviewed by Review Commons

Transient hypoxia followed by progressive reoxygenation is required for efficient skeletal muscle repair through Rev-ERBα modulation

1. Marie Quétin
2. Audrey Der Vartanian
3. Christelle Dubois
4. Juliette Berthier
5. Marine Ledoux
6. Stéphanie Michineau
7. Bernadette Drayton-Libotte
8. Athanassia Sotiropoulos
9. Frédéric Relaix
10. Marianne Gervais

Reviewed by Review Commons

Reconfiguration of tumor cells with LCOR transcription factor mRNA nanotherapy to enhance immunotherapy efficacy

1. Gabriel Serra-Mir
2. Elena Haro-Martínez
3. Chiara Cannatà
4. José Ángel Palomeque
5. Sandra Blasco-Benito
6. Anna López-Plana
7. María Sanz-Flores
8. Marc Sabartés
9. Cristina Fornaguera
10. Toni Celià-Terrassa

Reviewed by Review Commons

FAK modulates glioblastoma stem cell energetics via regulation of glycolysis and glutamine oxidation

1. Roza H. A. Masalmeh
2. John C. Dawson
3. Virginia Alvarez Garcia
4. Morwenna T. Muir
5. Roderick N. Carter
6. Giles Hardingham
7. Cameron Davies
8. Rosina Graham
9. Alex von Kriegsheim
10. Jair Marques Junior
11. Chinmayi Pednekar
12. Steven M. Pollard
13. Neil O. Carragher
14. Valerie G. Brunton
15. Margaret C. Frame

Reviewed by Review Commons

Fertilization triggers cytosolic functions and P-body recruitment of the RNA-binding protein Mei2 to drive fission yeast zygotic development

1. Ayokunle Araoyinbo
2. Clàudia Salat-Canela
3. Aleksandar Vještica

Reviewed by Review Commons

Genome-directed study reveals the diversity of Salmonella T6SS effectors and identifies a novel family of lipid-targeting antibacterial toxins

1. Gianlucca G. Nicastro
2. Stephanie Sibinelli-Sousa
3. Julia Takuno Hespanhol
4. Thomas W. C. Santos
5. Joseph P. Munoz
6. Rosangela S. Santos
7. Blanca M. Perez-Sepulveda
8. Sayuri Miyamoto
9. L. Aravind
10. Robson F. de Souza
11. Ethel Bayer-Santos

Reviewed by Review Commons

Single-cell analysis of signalling and transcriptional responses to type I interferons

1. Rachel E. Rigby
2. Kevin Rue-Albrecht
3. David Sims
4. Jan Rehwinkel

Reviewed by Review Commons

Live-cell imaging reveals nutrient-dependent dynamics of ER-mitochondria contact formation via PDZD8

1. Saeko Aoyama-Ishiwatari
2. Koki Nakamura
3. Takahiro Nagao
4. Yusuke Hirabayashi

Reviewed by Review Commons

The heterogeneity of dermal mesenchymal cells reproduced in skin equivalents regulates barrier function and elasticity

1. Shun Kimura
2. Sachiko Sekiya
3. Sawa Yamashiro
4. Tetsutaro Kikuchi
5. Masatoshi Haga
6. Tatsuya Shimizu

Reviewed by Review Commons

Sex-lethal is recruited to chromatin to promote neuronal tRNA synthesis in males through RNA Polymerase III regulation

1. Freya Storer
2. Colin D. McClure
3. Alicia Estacio Gomez
4. Tsz Lam Wong
5. Lucy J. Minkley
6. Tony D. Southall

Reviewed by Review Commons

Inherited CDA-I disease: anemia-associated mutations disrupt CDIN1-Codanin1 complex

1. Martin Stojaspal
2. Tomáš Brom
3. Ivona Nečasová
4. Tomáš Janovič
5. Pavel Veverka
6. Naina Verma
7. Lukáš Uhrík
8. Lenka Hernychova
9. Ctirad Hofr

Reviewed by Review Commons

Deciphering the CD73⁺ Regulatory γδ T Cell ecosystem associated with poor survival in Ovarian cancer

1. Ghita Chabab
2. Henri-Alexandre Michaud
3. Cécile Dejou
4. Laure-Agnès Chépeaux
5. Yaël Glasson
6. Florence Boissière
7. Marion Lenain
8. Anne-Sophie Dumé
9. Pauline Sarrant
10. Gabriel Chemin
11. Pauline Wajda
12. Bertrand Dubois
13. Anna MacManus
14. Pierre-Emmanuel Colombo
15. Michel Fabbro
16. Nathalie Bonnefoy
17. Maeva Chauvin
18. Virginie Lafont

Reviewed by Review Commons

Single molecule imaging of transcription dynamics, RNA localization and fate in human T cells

1. M. Valeria Lattanzio
2. Nikolina Šoštarić
3. Nandhini Kanagasabesan
4. Branka Popović
5. Antonia Bradarić
6. Leyma Wardak
7. Aurélie Guislain
8. Philipp Savakis
9. Evelina Tutucci
10. Monika C. Wolkers

Reviewed by Review Commons

Amyloid-β fibrils accumulated in preeclamptic placentas suppress syncytialization of cytotrophoblasts

1. Kaho Nishioka
2. Midori Ikezaki
3. Naoyuki Iwahashi
4. Miyu Arakawa
5. Momo Fukushima
6. Noa Mori
7. Mika Mizoguchi
8. Yuko Horiuchi-Tanizaki
9. Megumi Fujino
10. Takami Tomiyama
11. Yoshito Ihara
12. Kenji Uchimura
13. Kazuhiko Ino
14. Kazuchika Nishitsuji

Reviewed by Review Commons

A Drosophila screen of schizophrenia-related genes highlights the requirement of neural and glial matrix metalloproteinases for neuronal remodeling

1. Shir Keret
2. Hagar Meltzer
3. Neta Marmor-Kollet
4. Oren Schuldiner

Reviewed by Review Commons

Identifying regulators of associative learning using a protein-labelling approach in Caenorhabditis elegans

1. Aelon Rahmani
2. Anna McMillen
3. Ericka Allen
4. Radwan Ansaar
5. Renee Green
6. Michaela E Johnson
7. Anne Poljak
8. Yee Lian Chew

• Curated by eLife

  eLife Assessment

  In reporting on a valuable "learning proteome" for a C. elegans gustatory associative learning paradigm, this work identifies a new set of genes to be tested for roles in learning and memory, describes molecular pathways involving these genes and relevant for learning and memory in C. elegans, and deliver a new set of tools for prodding worm behavior. The methods and results convincingly support the findings, which will be of interest to neuroscientists and developmental biologists seeking to understand the self-assembly and operation of neural circuits for learning and memory.

  [Editors' note: this paper was reviewed by Review Commons.]

Reviewed by eLife, Review Commons

A conserved RNA switch for acetylcholine receptor clustering at neuromuscular junctions in chordates

1. Md. Faruk Hossain
2. Sydney Popsuj
3. Burcu Vitrinel
4. Nicole A. Kaplan
5. Alberto Stolfi
6. Lionel Christiaen
7. Matteo Ruggiu

Reviewed by Review Commons

Key roles of the zona pellucida and perivitelline space in promoting gamete fusion and fast block to polyspermy inferred from the choreography of spermatozoa in mice oocytes

1. Yaëlle Dubois
2. Sophie Favier
3. Nathan Martin-Fornier
4. Mohyeddine Omrane
5. David Stroebel
6. Eric Perez
7. Sandrine Barbaux
8. Ahmed Ziyyat
9. Nicolas Rodriguez
10. Christine Gourier

Reviewed by Review Commons

Lipid packing contributes to the confinement of caveolae to the plasma membrane

1. Elin Larsson
2. Aleksei Kabedev
3. Hudson Pace
4. Jakob Lindwall
5. Fouzia Bano
6. Robert G Parton
7. Christel AS Bergström
8. Ingela Parmryd
9. Marta Bally
10. Richard Lundmark

• Curated by eLife

  eLife Assessment

  This study reports the important finding that the dynamin inhibitor Dyngo-4a broadly affects lipid packing and plasma membrane dynamics, independently of its action on dynamin. While solid computational, biophysical, and cell-based evidence supports this conclusion, there is incomplete support for the authors' main claim on the role of lipid packing in caveolae internalization, as the causal relationship remains unclear and direct analyses are lacking. With stronger evidence, this work would be of significant interest to cell biologists, biophysicists, and chemists interested in membrane remodeling and drug-membrane interactions.

  [Editors' note: this paper was reviewed by Review Commons.]

Reviewed by eLife, Review Commons

TORC2-regulated sterol redistribution mediates recovery from membrane perturbation by small amphipathic molecules.

1. Maria G. Tettamanti
2. Paulina Nowak
3. Beata Kusmider
4. Jennifer M Kefauver
5. Vincent Mercier
6. Aurelien Roux
7. Robbie Loewith

Reviewed by Review Commons