Evaluated articles

Interpreting the Effects of DNA Polymerase Variants at the Structural Level Using MAVISp and Molecular Dynamics Simulations

1. Matteo Arnaudi
2. Karolina Krzesińska
3. Ludovica Beltrame
4. Pablo Sánchez-Izquierdo Besora
5. Matteo Tiberti
6. Mef Nilbert
7. Anna Rohlin
8. Elena Papaleo

Reviewed by Review Commons

Non-synaptic exocytosis along the axon shaft and its regulation by the submembrane periodic skeleton

1. Theresa Wiesner
2. Christopher Parperis
3. Fanny Boroni-Rueda
4. Nicolas Jullien
5. Afonso Mendes
6. Léa Marie
7. Louisa Mezache
8. Marie-Jeanne Papandréou
9. Ricardo Henriques
10. Christophe Leterrier

Reviewed by Review Commons

Specialization of ubiquitin ligases to distinct nucleic acid sensors

1. Ibrahim Syed
2. Sheng Chen
3. David J. Peeler
4. Paul F. McKay
5. Marco A. Briones-Orta
6. Jennifer A. Bohn
7. Robin J. Shattock
8. Daniel Gonçalves-Carneiro

Reviewed by Review Commons

The environmental stress response controls the biophysical properties of the cytoplasm and is critical for survival in quiescence

1. Lorena Kronig
2. Carmen A. Weber
3. Pablo Aurelio Gómez-García
4. Jonas S. Fischer
5. Christian Doerig
6. Agnès Michel
7. Paolo Ronchi
8. Sarah Khawaja
9. Paola Picotti
10. Benoît Kornmann
11. Karsten Weis

Reviewed by Review Commons

Drosophila host defense mechanisms against filamentous fungal pathogens with diverse lifestyles

1. Guiqing Liu
2. Yao Tian
3. Mark Austin Hanson
4. Prince Kumar Sah
5. Jun Li
6. Bruno Lemaitre

Reviewed by Review Commons

A genotype-phenotype transformer to assess and explain polygenic risk

1. Ingoo Lee
2. Zachary S. Wallace
3. Yuqi Wang
4. Sungjoon Park
5. Hojung Nam
6. Amit R. Majithia
7. Trey Ideker

Reviewed by Review Commons

Genetic and environmental determinants of multicellular-like phenotypes in fission yeast

1. Bence Kӧvér
2. Céleste E Cohen
3. Ladislav Seres
4. Saniya Raut
5. Markus Ralser
6. Benjamin M Heineike
7. Jürg Bähler

Reviewed by Review Commons

Plasmin activity and sterile inflammation synergize to promote lethal embryonic liver degeneration

1. Meng-Ling Wu
2. Courtney T. Griffin

Reviewed by Review Commons

Large-scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of α-synuclein aggregation

1. Sandesh Neupane
2. Lea Nikolić
3. Lorenzo Maraio
4. Thomas Goiran
5. Nathan Karpilovsky
6. Stefano Sellitto
7. Vangelis Bouris
8. Jiang-An Yin
9. Ronald Melki
10. Edward A. Fon
11. Elena De Cecco
12. Adriano Aguzzi

Reviewed by Review Commons

Contractile perinuclear actomyosin network promotes peripheral and polar chromosome interaction with the mitotic spindle

1. Nooshin Sheidaei
2. John K Eykelenboom
3. Zuojun Yue
4. Graeme Ball
5. Alexander JR Booth
6. Tomoyuki U Tanaka

• Curated by eLife

  eLife Assessment

  This important study demonstrates that a perinuclear actomyosin network, present in some types of human cells, facilitates kinetochore-spindle attachment of chromosomes in unfavorable locations, thereby reducing their missegregation rate. This actomyosin network and its general role have been studied previously, but this study convincingly clarifies the underlying mechanism and expands the investigation to additional cell lines. The results are relevant to understanding chromosome missegregation in cancer cells.

  [Editors' note: this paper was reviewed by Review Commons.]

Reviewed by eLife, Review Commons

Natural Killer Cell Receptor Signaling and Activation Depend on Cell Cycle Stages

1. Darren Wethington
2. Indrani Nayak
3. Helle Jensen
4. William C. Stewart
5. Oscar A. Aguilar
6. Shih-Yu Chen
7. Garry P. Nolan
8. Gregory K. Behbehani
9. Lewis L. Lanier
10. Jayajit Das

Reviewed by Review Commons

Lysosome-Dependent Sphingolipid Regulation as a potential therapeutic Target for Cohen Syndrome

1. Fabrizio Vacca
2. Renuka Prasad
3. Huda Barakullah
4. Romain Da Costa
5. Stefania Vossio
6. Dimitri Moreau
7. Woong Sun
8. Howard Riezman
9. Muhammad Ansar

Reviewed by Review Commons

Cdk1 and PP2A constitute a molecular switch controlling orderly degradation of atypical E2Fs

1. Sapir Nachum-Raines
2. Noy Gamliel
3. Danit Wasserman
4. Nasrin Qassem
5. Inbal Sher
6. Julia Guez-Haddad
7. Michael J Emanuele
8. Jordan H Chill
9. Amit Tzur

Reviewed by Review Commons

Targeted disruption of phage liquid crystalline droplets abolishes antibiotic tolerance of bacterial biofilms

1. Abul K. Tarafder
2. Miles Graham
3. Luke K. Davis
4. Shawna Pratt
5. Jan Böhning
6. Pavithra Manivannan
7. Zhexin Wang
8. Camila M. Clemente
9. Raymond J Owens
10. George A. O’Toole
11. Philip Pearce
12. Tanmay A.M. Bharat

Reviewed by Review Commons

VAMP8 function reveals tight linkage between endocytic recycling and endocytosis

1. Ailing Liu
2. Yueping Li
3. Zheng Huang
4. Wen Chen
5. Peiliu Xu
6. Xiangying Wei
7. Guosheng Hu
8. Shuangquan Liu
9. Xiaoxia Liu
10. Yaohui He
11. Danling Wang
12. Sandra L. Schmid
13. Zhiming Chen

Reviewed by Review Commons

Ubiquitination regulates granulostasis and DRiP accumulation in SGs under heat stress via the E3 ligase MKRN2

1. Emmanuel Amzallag
2. Yehuda M. Danino
3. Valentina Secco
4. Serena Carra
5. Eran Hornstein

Reviewed by Review Commons

LGL-1 and the RhoGAP protein PAC-1 redundantly polarize the C. elegans embryonic epidermis

1. Olga D. Jarosińska
2. Amalia Riga
3. Hala Zahreddine Fahs
4. Joren M. Woeltjes
5. Ruben Schmidt
6. Fathima S. Refai
7. Suma Gopinadhan
8. Kristin C. Gunsalus
9. Mike Boxem

Reviewed by Review Commons

HIV-1 envelope glycoprotein modulates CXCR4 clustering and dynamics on the T cell membrane

1. Adriana Quijada-Freire
2. César A Santiago
3. Eva M García-Cuesta
4. Blanca Soler Palacios
5. Rosa Ayala-Bueno
6. Sofia R Gardeta
7. Enara San Sebastian
8. Eva Armendariz-Burgoa
9. Maria Carmen Puertas
10. Ricardo Villares
11. Urtzi Garaigorta
12. Luis Ignacio González-Granado
13. Jose Miguel Rodriguez Frade
14. Jakub Chojnacki
15. Javier Martinez-Picado
16. Mario Mellado

• Curated by eLife

  eLife Assessment

  This study provides valuable insights into how HIV-1 Env modulates the nanoscale organization and dynamics of the CXCR4 co-receptor on T cells, using quantitative imaging and functional approaches, the authors present convincing evidence that gp120 engagement promotes CD4-dependent clustering and altered mobility of CXCR4, distinct from the effects of the natural ligand CXCL12. Some concerns were raised regarding the interpretation of the single-particle tracking analyses, and additional clarification or analysis may help strengthen the conclusions. The physiological relevance of the findings could be further enhanced by validation with infectious virus and by more clearly integrating the CXCR4R334X mutant observations into the central mechanistic narrative. The work will be of interest to researchers studying HIV entry and membrane receptor organization.

  [Editors' note: this paper was reviewed by Review Commons.]

Reviewed by eLife, Review Commons

From Noise to Models to Numbers: Evaluating Negative Binomial Models and Parameter Estimations in Single-Cell RNA-seq

1. Yiling Wang
2. Zhanpeng Shu
3. Zhixing Cao
4. Ramon Grima

Reviewed by Review Commons

Cell type specific allometry controls sex-differences in Drosophila organ size

1. Soumitra Pal
2. Jerome Avellaneda
3. Celena M Cherian
4. Puja Biswas
5. Georg Vogler
6. Elizabeth J Rideout
7. Frank Schnorrer
8. Teresa M Przytycka
9. Brian Oliver

Reviewed by Review Commons