Evaluated articles

Quantitative comparison of PI(3,5)P ₂ biosensors reveals SnxA is the most sensitive and unbiased

1. Tiernan Swayhoover
2. Claire C. Weckerly
3. Gerald R. V. Hammond

Reviewed by Review Commons

Metabolic Trans-Omic Analysis Reveals Key Regulatory Disruption of Energy Metabolism in Alzheimer’s Disease

1. Tomoharu Katayama
2. Hikaru Sugimoto
3. Keigo Morita
4. Hirohisa Watanabe
5. Shinya Kuroda

• Curated by eLife

  eLife Assessment

  This study presents a useful application of trans-omic network analyses to existing human brain datasets, generating systems-level insights into metabolic dysregulation in Alzheimer's disease. Overall, the authors' analytical choices are solid, with appropriate use of existing data and methods, and with many of their results confirming previous findings. However, some of the authors' key claims, related to previously unknown details of regulatory relationships, are only partially supported due to limitations in dataset cell-type resolution and network robustness, as well as a lack of functional validation. This work will be of interest to cellular or systems neurobiologists studying Alzheimer's disease and could serve as a helpful starting point for future work.

  [Editors' note: this paper was reviewed by Review Commons.]

Reviewed by eLife, Review Commons

Mechanism of activation of an ancestral TEC kinase by PIP ₃

1. Eva Krötenheerdt
2. Lucas Piëch
3. Freia von Raußendorf
4. Ronja Reinhardt
5. Nicholas Wedige
6. Hunter G. Nyvall
7. Emma E. Walsh
8. John E. Burke
9. Thomas A. Leonard

Reviewed by Review Commons

CD8 T lymphocytes redeploy embryonic cell cycle control mechanisms to facilitate rapid cell proliferation

1. D. A. Lewis
2. A. Kar
3. A. Savage
4. V. Kelly
5. D. Wright
6. R. Zamoyska
7. T. Ly

Reviewed by Review Commons

Cross-species transcriptomic integration reveals a MIRO1-mediated macrophage–T cell axis in glioma

1. Zehui Du
2. Menghan Li
3. Brandon H Bergsneider
4. Andy P Tsai
5. Kwang Bog Cho
6. Lily H Kim
7. John Choi
8. Gordon Li
9. Tony Wyss-Coray
10. Michael Lim
11. Xinnan Wang

Reviewed by Review Commons

MAVS is Important for Antiviral Defense Against Influenza A Virus in a Human Respiratory Epithelium Model

1. Maja Hemberg
2. Anne Louise Hansen
3. Jacob Storgaard
4. Julia Blay-Cadanet
5. Alice Pedersen
6. Anne Laugaard Thielke
7. Christian Kanstrup Holm

Reviewed by Review Commons

Unconventional components complement the cryptic kinetochore of the ciliate Tetrahymena thermophila

1. Emine I. Ali
2. Maximilian W. D. Raas
3. Laura E. van Rooijen
4. Paula Sobrevals Alcaraz
5. Harmjan R. Vos
6. Eelco C. Tromer
7. Berend Snel
8. Geert J.P.L. Kops

Reviewed by Review Commons

An actomyosin-mediated mechanical mechanism for brain neural tube elevation

1. Juana De La O
2. Chidera Okeke
3. Gabriel L. Galea
4. Adam C. Martin

Reviewed by Review Commons

Nrf2 promotes thyroid development and hormone synthesis

1. Gillotay Pierre
2. Romitti Mirian
3. Dassy Benjamin
4. Haerlingen Benoit
5. Parakkal Shankar Meghna
6. Faria Fonseca Barbara
7. Ziros G. Panos
8. Pal Singh Sumeet
9. Sykiotis P. Gerasimos
10. Costagliola Sabine

Reviewed by Review Commons

Short chain fatty acids regulate the chromatin landscape and distinct gene expression changes in human colorectal cancer cells

1. Tohfa Kabir
2. Charlotte A. Connamacher
3. Zara Nadeem
4. Matthew R. Paul
5. Matthew R. Smutny
6. Zoe K. Lawler
7. Annaelle M. Djomo
8. Thomas S. Carroll
9. Leah A. Gates

Reviewed by Review Commons

FuChi: A cell cycle biosensor for investigating cell-cycle kinetics during avian development

1. Zoe R. Sudderick
2. Tiernan Briggs
3. Shirooza Mubarak
4. Melinda Van Kerckvoorde
5. Ana R. Hernandez-Rodriguez
6. Sudeepta K. Panda
7. Jon Riddell;
8. Cameron Batho-Samblas
9. Lorna Taylor
10. Lynn McTeir
11. Dominique Meunier
12. Amy Findlay
13. Flossie Roberts
14. Anna Raper
15. Asako Sakaue-Sawano
16. Atsushi Miyawaki
17. Joe Rainger
18. Jeffrey J. Schoenebeck
19. Cornelis J. Weijer
20. Mike J. McGrew
21. Denis J. Headon
22. Megan G. Davey
23. Richard L. Mort
24. James D. Glover

Reviewed by Review Commons

LRRK2 mutations block NCOA4 trafficking upon iron overload leading to ferroptotic death

1. Andres Goldman
2. Mai Nguyen
3. Joel Lanoix
4. Chongyang Li
5. Ahmed Fahmy
6. Yong Zhong Xu
7. Erwin Schurr
8. Pierre Thibault
9. Michel Desjardins
10. Heidi M. McBride

Reviewed by Review Commons

Macrophages maintain signaling fidelity in response to ligand mixtures

1. Xiaolu Guo
2. Supriya Sen
3. Julian Gonzalez
4. Alexander Hoffmann

Reviewed by Review Commons

The role of MICOS in organizing mitochondrial cristae in malaria parasites

1. Silvia Tassan-Lugrezin
2. Irina Bregy
3. Judith López Orra
4. Nicholas I Proellochs
5. Geert-Jan van Gemert
6. Rianne Stoter
7. Felix Evers
8. Taco WA Kooij
9. Laura van Niftrik

• Curated by eLife

  eLife Assessment

  This study provides valuable insights into mitochondrial cristae organization in Plasmodium falciparum, particularly in the context of its divergent MICOS composition. The authors present convincing evidence, supported by phenotypic and morphological analyses, that cristae junction maintenance can be uncoupled from de novo cristae formation, reinforcing an emerging model of mitochondrial inner membrane organization. Notably, the absence of Mic10 alongside an enlarged and divergent MICOS complex highlights an intriguing evolutionary adaptation, although further characterization of the complex would strengthen the study's overall significance.

  [Editors' note: this paper was reviewed by Review Commons.]

Reviewed by eLife, Review Commons

Identifying and targeting abnormal mitochondrial localization associated with psychosis

1. Marzieh Haghighi
2. Donna McPhie
3. Mohammad Rohban
4. Erin Weisbart
5. David J Logan
6. Kyle W Karhohs
7. Suzann M Babb
8. Jessica D Ewald
9. Johan Fredin Haslum
10. Caitlin Ravichandran
11. Beth A Cimini
12. Shantanu Singh
13. Bruce M Cohen
14. Anne E Carpenter

Reviewed by Review Commons

Four new Duchenne muscular dystrophy mouse models with clinically relevant exon deletions in the human DMD gene

1. Maaike van Putten
2. Margot Linssen
3. Christa Tanganyika-de Winter
4. Conny M. Brouwers
5. Jill W.C. Claassens
6. Nisha Verwey
7. Max Walsh
8. Tiberiu Loredan Stan
9. Annemieke Aartsma-Rus
10. Peter Hohenstein

Reviewed by Review Commons

A bipartite, mutation-tolerant NLS regulates interaction of ΔNp63α with importin alpha, nuclear transport and transcriptional activity

1. Anna Demarinis
2. Sara Esmaeili
3. Crystall M. D. Swarbrick
4. Simone Ranno
5. Silvia Pavan
6. Jade K. Forwood
7. Brian P. McSharry
8. Martin Pal
9. Enzo Di Iorio
10. Gualtiero Alvisi

Reviewed by Review Commons