Evaluated articles

A list by Review Commons

Articles that have been evaluated by Review Commons.

1279 articlesLast updated

Related articles (Labs 🧪)

Showing page 9 of 64

  3. Δ133p53α and Δ160p53α isoforms of the tumor suppressor protein p53 exert dominant-negative effect primarily by co-aggregation

    1. Liuqun Zhao
    2. Tanel Punga
    3. Suparna Sanyal

    • Curated by eLife

      eLife Assessment

      This important study investigates the molecular mechanisms by which the p53 isoforms Δ133p53α and Δ160p53α exert dominant-negative effects on full-length p53 (FLp53). Through a combination of chromatin immunoprecipitation, transcriptional reporter assays, subcellular localization analyses, and protein aggregation experiments, the authors provide solid evidence that these N-terminally truncated isoforms promote co-aggregation with FLp53, disrupting its transcriptional activity and cellular distribution. The revised manuscript successfully addresses prior reviewer concerns, and the findings are well supported by the experimental data.

      [Editors' note: this paper was reviewed by Review Commons.]

    Reviewed by eLife, Review Commons

    8 evaluationsAppears in 2 listsLatest version Latest activity

  4. Regional heterogeneities of oligodendrocytes determine biased distribution pattern of Ranvier nodes along single axons in sound localization circuit

    1. Ryo Egawa
    2. Kota Hiraga
    3. Ryosuke Matsui
    4. Dai Watanabe
    5. Hiroshi Kuba

    • Curated by eLife

      eLife Assessment

      This important study uses the delay line axon model in the chick brainstem auditory circuit to examine the interactions between oligodendrocytes and axons in the formation of internodal distances. This is a significant and actively studied topic, and the authors have used this preparation to support the hypothesis that regional heterogeneity in oligodendrocytes underlies the observed variation in internodal length. In a solid series of experiments, the authors have used enhanced tetanus neurotoxin light chains, a genetically encoded silencing tool, to inhibit vesicular release from axons and support the hypothesis that regional heterogeneity among oligodendrocytes may underlie the biased nodal spacing pattern in the sound localization circuit.

      [Editors' note: this paper was reviewed by Review Commons.]

    Reviewed by eLife, Review Commons

    13 evaluationsAppears in 2 listsLatest version Latest activity

  10. Ribosomal RNA synthesis by RNA polymerase I is regulated by premature termination of transcription

    1. ChaĂŻma Azouzi
    2. Katrin Schwank
    3. Sophie Queille
    4. Marta Kwapisz
    5. Marion Aguirrebengoa
    6. Anthony Henras
    7. Simon Lebaron
    8. Herbert Tschochner
    9. Annick Lesne
    10. Frédéric Beckouët
    11. Olivier Gadal
    12. Christophe Dez

    • Curated by eLife

      eLife Assessment

      This manuscript characterizes a mutated clone of RNA polymerase I in yeast, referred to as SuperPol, to understand the mechanisms of RNA polymerase I elongation and termination. The authors present solid evidence that SuperPol has higher processivity during transcription elongation than wild-type RNA polymerase I. Notably, the study provides evidence that the transcriptional pause of RNA polymerase I may be a therapeutic vulnerability in cancers. Overall, the characterization of this RNA pol I is important as it provides insights into the regulation of ribosomal RNA transcription and its potential application in cancer pharmacology.

      [Editors' note: this paper was reviewed by Review Commons.]

    Reviewed by eLife, Review Commons

    9 evaluationsAppears in 2 listsLatest version Latest activity

  11. Modularity of the segmentation clock and morphogenesis

    1. James E Hammond
    2. Ruth E Baker
    3. Berta Verd

    • Curated by eLife

      eLife Assessment

      This valuable manuscript uses mathematical modeling to address the synchrony of the vertebrate segmentation clock with the developmental processes. The authors use convincing arguments to support the idea that this would allow the evolution of flexible body plans and a variable number of segments. This manuscript could be of interest to developmental biologists and systems biologists.

      [Editors' note: this paper was reviewed by Review Commons.]

    Reviewed by eLife, Review Commons

    9 evaluationsAppears in 2 listsLatest version Latest activity

  13. Epigenetic liquid biopsies reveal elevated vascular endothelial cell turnover and erythropoiesis in asymptomatic COVID-19 patients

    1. Roni Ben-Ami
    2. Netanel Loyfer
    3. Eden Cohen
    4. Gavriel Fialkoff
    5. Israa Sharkia
    6. Naama Bogot
    7. Danit Kochan
    8. George Kalak
    9. Amir Jarjoui
    10. Chen Chen-Shuali
    11. Hava Azulai
    12. Hezi Barhoum
    13. Nissim Arish
    14. Moshe M Greenberger
    15. David Vellema
    16. Ramzi Kurd
    17. Eli Ben Chetrit
    18. Davina Bohm
    19. Talya Wolak
    20. Ahmad Quteineh
    21. Gordon Cann
    22. Benjamin Glaser
    23. Nir Friedman
    24. Tommy Kaplan
    25. Ruth Shemer
    26. Ariel Rokach
    27. Yuval Dor

    Reviewed by Review Commons, Rapid Reviews Infectious Diseases

    6 evaluationsAppears in 2 listsLatest version Latest activity

  19. Kinetic regulation of kinesin’s two motor domains coordinates its stepping along microtubules

    1. Yamato Niitani
    2. Kohei Matsuzaki
    3. Erik Jonsson
    4. Ronald D Vale
    5. Michio Tomishige

    • Curated by eLife

      eLife Assessment

      This study provides compelling evidence that kinesin's stepping mechanism is governed by strain-induced conformational changes in its nucleotide-binding pockets. Using pre-steady state kinetics and single-molecule assays, the authors demonstrate that the neck linker's conformation differentially modulates nucleotide affinity and detachment rates, establishing an asynchronous chemo-mechanical cycle that prevents simultaneous detachment. Supported by cryo-EM structural data, the work presents an important advance in our understanding of kinesin's hand-over-hand movement.

      [Editors' note: this paper was reviewed by Review Commons.]

    Reviewed by eLife, Review Commons

    9 evaluationsAppears in 2 listsLatest version Latest activity
Next