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  1. Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients: a randomized, double-blind, placebo-controlled phase 2 trial

    This article has 33 authors:
    1. Lei Shi
    2. Hai Huang
    3. Xuechun Lu
    4. Xiaoyan Yan
    5. Xiaojing Jiang
    6. Ruonan Xu
    7. Siyu Wang
    8. Chao Zhang
    9. Xin Yuan
    10. Zhe Xu
    11. Lei Huang
    12. Jun-Liang Fu
    13. Yuanyuan Li
    14. Yu Zhang
    15. Wei-Qi Yao
    16. Tianyi Liu
    17. Jinwen Song
    18. Liangliang Sun
    19. Fan Yang
    20. Xin Zhang
    21. Bo Zhang
    22. Ming Shi
    23. Fanping Meng
    24. Yanning Song
    25. Yongpei Yu
    26. Jiqiu Wen
    27. Qi Li
    28. Qing Mao
    29. Markus Maeurer
    30. Alimuddin Zumla
    31. Chen Yao
    32. Wei-Fen Xie
    33. Fu-Sheng Wang

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  2. The folate antagonist methotrexate diminishes replication of the coronavirus SARS-CoV-2 and enhances the antiviral efficacy of remdesivir in cell culture models

    This article has 18 authors:
    1. Kim M. Stegmann
    2. Antje Dickmanns
    3. Sabrina Gerber
    4. Vella Nikolova
    5. Luisa Klemke
    6. Valentina Manzini
    7. Denise Schlösser
    8. Cathrin Bierwirth
    9. Julia Freund
    10. Maren Sitte
    11. Raimond Lugert
    12. Gabriela Salinas
    13. Toni Luise Meister
    14. Stephanie Pfaender
    15. Dirk Görlich
    16. Bernd Wollnik
    17. Uwe Groß
    18. Matthias Dobbelstein

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  3. Enisamium Inhibits SARS-CoV-2 RNA Synthesis

    This article has 15 authors:
    1. Stefano Elli
    2. Denisa Bojkova
    3. Marco Bechtel
    4. Thomas Vial
    5. David Boltz
    6. Miguel Muzzio
    7. Xinjian Peng
    8. Federico Sala
    9. Cesare Cosentino
    10. Andrew Goy
    11. Marco Guerrini
    12. Lutz MĂŒller
    13. Jindrich Cinatl
    14. Victor Margitich
    15. Aartjan J. W. te Velthuis

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  4. Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19

    This article has 21 authors:
    1. Courtney Tindle
    2. MacKenzie Fuller
    3. Ayden Fonseca
    4. Sahar Taheri
    5. Stella-Rita Ibeawuchi
    6. Nathan Beutler
    7. Gajanan Dattatray Katkar
    8. Amanraj Claire
    9. Vanessa Castillo
    10. Moises Hernandez
    11. Hana Russo
    12. Jason Duran
    13. Laura E Crotty Alexander
    14. Ann Tipps
    15. Grace Lin
    16. Patricia A Thistlethwaite
    17. Ranajoy Chattopadhyay
    18. Thomas F Rogers
    19. Debashis Sahoo
    20. Pradipta Ghosh
    21. Soumita Das
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      The manuscript by Tindle et al describes generation of adult lung organoids (ALO) from human lung biopsies and their use to study the changes in gene expression as a result of SARS-CoV-2 infection. In this particular case the authors report the presence of AT1, AT2 cells, Basal cells, Goblet cells, Ciliated cells and Club cells. The authors were able to cultivate the cells at the air-liquid interface and to establish cultures of predominately proximal and predominately distal airway cells. The main finding is that proximal cells are more prone to viral infection, while distal cells are governing the exuberant inflammatory response, with both cells required for the exuberant response to occur. Useful information provided by the paper is the analysis gene signatures of various cellular models, in comparison to the infected human lung.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

    Reviewed by eLife, ScreenIT

    This article has 6 evaluationsAppears in 2 listsLatest version Latest activity