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A list by Prachee Avasthi Recommended Reading

See what researchers at Prachee Avasthi’s lab are reading to discover some interesting new work.

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  12. Increasing cell size remodels the proteome and promotes senescence

    1. Michael C. Lanz
    2. Evgeny Zatulovskiy
    3. Matthew P. Swaffer
    4. Lichao Zhang
    5. Ilayda Ilerten
    6. Shuyuan Zhang
    7. Dong Shin You
    8. Georgi Marinov
    9. Patrick McAlpine
    10. Joshua E. Elias
    11. Jan M. Skotheim
    Appears in 1 listLatest version

  16. Evolutionary conservation of centriole rotational asymmetry in the human centrosome

    1. Noémie Gaudin
    2. Paula Martin Gil
    3. Meriem Boumendjel
    4. Dmitry Ershov
    5. Catherine Pioche-Durieu
    6. Manon Bouix
    7. Quentin Delobelle
    8. Lucia Maniscalco
    9. Than Bich Ngan Phan
    10. Vincent Heyer
    11. Bernardo Reina-San-Martin
    12. Juliette Azimzadeh

    • Curated by eLife

      Evaluation Summary:

      This paper shows that centrioles of the human centrosome are rotationally asymmetric, a feature previously known only from centrioles in flagellated protists and in multi-ciliated cells. The authors, identify LRRCC1, implicated in human ciliopathy, as a component that localizes asymmetrically on one side of the distal lumen, contributing to proper centriole structure, ciliary assembly and ciliary signaling. This work is of interest to cell biologists studying how centriole assembly and function is linked to human disease.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife

    5 evaluationsAppears in 2 listsLatest version Latest activity

  20. Changes in seam number and location induce holes within microtubules assembled from porcine brain tubulin and in Xenopus egg cytoplasmic extracts

    1. Charlotte Guyomar
    2. Clément Bousquet
    3. Siou Ku
    4. John M Heumann
    5. Gabriel Guilloux
    6. Natacha Gaillard
    7. Claire Heichette
    8. Laurence Duchesne
    9. Michel O Steinmetz
    10. Romain Gibeaux
    11. Denis Chrétien

    • Curated by eLife

      eLife assessment

      The study, using cryo-electron tomography represents a valuable study to the research community, to raise awareness that in vitro-assembled microtubules have more lattice defects than microtubules assembled in cell extracts. However the evidence supporting the claims was incomplete in places and there was not enough data. It is not clear how generalizable these findings are regarding tubulin assembly into microtubules.

    Reviewed by eLife

    5 evaluationsAppears in 2 listsLatest version Latest activity
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