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  1. The transcription factor Bach2 negatively regulates murine natural killer cell maturation and function

    This article has 11 authors:
    1. Shasha Li
    2. Michael D Bern
    3. Benpeng Miao
    4. Changxu Fan
    5. Xiaoyun Xing
    6. Takeshi Inoue
    7. Sytse J Piersma
    8. Ting Wang
    9. Marco Colonna
    10. Tomohiro Kurosaki
    11. Wayne M Yokoyama
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      The strength of this paper is identifying a novel factor Bach2 that might be involved in the generation and/or maintenance of NK cells. To date, the full molecular network guiding the development, maturation and maintenance of NK cells has not been fully defined and Bach2 has not yet been investigated.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by PREreview, eLife

    This article has 7 evaluationsAppears in 3 listsLatest version Latest activity
  2. Progenitor identification and SARS-CoV-2 infection in long-term human distal lung organoid cultures

    This article has 34 authors:
    1. Ameen A. Salahudeen
    2. Shannon S. Choi
    3. Arjun Rustagi
    4. Junjie Zhu
    5. Sean M. de la O
    6. Ryan A. Flynn
    7. Mar Margalef-Català
    8. António J. M. Santos
    9. Jihang Ju
    10. Arpit Batish
    11. Vincent van Unen
    12. Tatsuya Usui
    13. Grace X.Y. Zheng
    14. Caitlin E. Edwards
    15. Lisa E. Wagar
    16. Vincent Luca
    17. Benedict Anchang
    18. Monica Nagendran
    19. Khanh Nguyen
    20. Daniel J. Hart
    21. Jessica M. Terry
    22. Phillip Belgrader
    23. Solongo B. Ziraldo
    24. Tarjei S. Mikkelsen
    25. Pehr B. Harbury
    26. Jeffrey S. Glenn
    27. K. Christopher Garcia
    28. Mark M. Davis
    29. Ralph S. Baric
    30. Chiara Sabatti
    31. Manuel R. Amieva
    32. Catherine A. Blish
    33. Tushar J. Desai
    34. Calvin J. Kuo

    Reviewed by PREreview, ScreenIT

    This article has 5 evaluationsAppears in 2 listsLatest version Latest activity
  3. The evolution of colistin resistance increases bacterial resistance to host antimicrobial peptides and virulence

    This article has 12 authors:
    1. Pramod K Jangir
    2. Lois Ogunlana
    3. Petra Szili
    4. Marton Czikkely
    5. Liam P Shaw
    6. Emily J Stevens
    7. Yang Yu
    8. Qiue Yang
    9. Yang Wang
    10. Csaba Pál
    11. Timothy R Walsh
    12. Craig R MacLean
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      Antimicrobial peptides (AMP) are a class of antibiotics that are inspired by natural components of innate immunity, which raises the specter of bacteria becoming resistant to both. The author this important study test this idea and find compelling evidence that a plasmid that encodes resistance to the AMP colistin also increases resistance to AMPS produced by humans, pigs, and chickens, enables the bacteria to grow better in low levels of AMP, and increases bacterial virulence in an insect model of infection. The study will be of interest to both evolutionary biologists and microbiologists focused on antimicrobial therapy and suggests that the evolution of resistance to these compounds can have collateral effects on immune evasion as well.

    Reviewed by eLife, PREreview

    This article has 5 evaluationsAppears in 3 listsLatest version Latest activity
  4. Tardigrade CAHS Proteins Act as Molecular Swiss Army Knives to Mediate Desiccation Tolerance Through Multiple Mechanisms

    This article has 15 authors:
    1. Cherie S. Hesgrove
    2. Kenny H. Nguyen
    3. Sourav Biswas
    4. Charles A. Childs
    5. KC Shraddha
    6. Bryan X. Medina
    7. Vladimir Alvarado
    8. Feng Yu
    9. Shahar Sukenik
    10. Marco Malferrari
    11. Francesco Francia
    12. Giovanni Venturoli
    13. Erik W. Martin
    14. Alex S. Holehouse
    15. Thomas C. Boothby

    Reviewed by PREreview

    This article has 1 evaluationAppears in 1 listLatest version Latest activity