Reading List

Scorpion α-toxin LqhαIT specifically interacts with a glycan at the pore domain of voltage-gated sodium channels

1. Swastik Phulera
2. Callum J. Dickson
3. Christopher J. Schwalen
4. Maryam Khoshouei
5. Samantha J. Cassell
6. Yishan Sun
7. Tara Condos
8. Jonathan Whicher
9. Wilhelm A. Weihofen

Constitutive sodium permeability in a C. elegans two-pore domain potassium channel

1. O Andrini
2. I Ben Soussia
3. P Tardy
4. DS Walker
5. C Peña-Varas
6. D Ramírez
7. M Gendrel
8. M Mercier
9. S El Mouridi
10. A Leclercq-Blondel
11. W González
12. WR Schafer
13. M Jospin
14. T Boulin

On the lipid dependence of bacterial mechanosensitive channel gating in situ

1. Madolyn Britt
2. Katsuhiro Sawasato
3. Elissa Moller
4. Gerald Kidd
5. Mikhail Bogdanov
6. Sergei Sukharev

Conformational Changes of the ABC Transporter BmrA Depend on Membrane Curvature

1. Alicia Damm
2. Kemil Belhadji
3. Raj Kumar Sadhu
4. Su-Jin Paik
5. Aurélie Di-Cicco
6. John Manzi
7. Michele Castellana
8. Raju Regmi
9. Emmanuel Margeat
10. Maxime Dahan
11. Pierre Sens
12. Daniel Lévy
13. Patricia Bassereau

• Curated by eLife

  eLife Assessment

  This valuable study investigates whether the activity of an ABC transporter, BmrA, can be modulated by mechanical stimuli. The authors develop a single-molecule experimental system to address this question, although aspects of the methodological framework are incomplete. This work also develops a convincing theoretical model to explain the effect of membrane curvature on the conformational transitions observed during the activity cycle of this membrane protein. This study is of interest to the fields of membrane biophysics and membrane transport.

Reviewed by eLife

The lipid-mediated mechanism of mechanosensitive channel MscS inactivation

1. Elissa Moller
2. Madolyn Britt
3. Fei Zhou
4. Hyojik Yang
5. Andriy Anishkin
6. Robert Ernst
7. Juan M. Vanegas
8. Sergei Sukharev
9. Doreen Matthies

They all rock: A systematic comparison of conformational movements in LeuT-fold transporters

1. Jacob A. Licht
2. Samuel P. Berry
3. Michael A. Gutierrez
4. Rachelle Gaudet

ACKR3 Proximity Labeling Identifies Novel G protein- and β-arrestin-independent GPCR Interacting Proteins

1. Chloe Hicks
2. Julia Gardner
3. Dylan Scott Eiger
4. Nicholas D. Camarda
5. Uyen Pham
6. Saisha Dhar
7. Hailey Rodriguez
8. Anand Chundi
9. Sudarshan Rajagopal

Molecular mechanism of β-arrestin-2 interaction with phosphatidylinositol 4,5-bisphosphate

1. Kiae Kim
2. Ka Young Chung

Freestanding bilayer microscope for single-molecule imaging of membrane proteins

1. Gonzalo Pérez-Mitta
2. Yeliz Sezgin
3. Weiwei Wang
4. Roderick MacKinnon

Structure of the extracellular region of the adhesion GPCR CELSR1 reveals a compact module which regulates G protein-coupling

1. Sumit J. Bandekar
2. Krassimira Garbett
3. Szymon P. Kordon
4. Ethan Dintzner
5. Tanner Shearer
6. Richard C. Sando
7. Demet Araç

Different fluorescent labels report distinct components of spHCN channel voltage sensor movement

1. Magdalena N Wojciechowski
2. Chaseley E McKenzie
3. Andrew Hung
4. Alibek Kuanyshbek
5. Ming S Soh
6. Christopher A Reid
7. Ian C Forster

Divergent mechanisms of steroid inhibition in the human ρ1 GABA _A receptor

1. Chen Fan
2. John Cowgill
3. Rebecca J. Howard
4. Erik Lindahl

Reviewed by PREreview

Identification of a binding site for small molecule inhibitors targeting human TRPM4

1. Babatunde Ekundayo
2. Prakash Arullampalam
3. Christian E. Gerber
4. Anne-Flore Hämmerli
5. Sabrina Guichard
6. Mey Boukenna
7. Daniela Ross-Kaschitza
8. Martin Lochner
9. Jean-Sebastien Rougier
10. Henning Stahlberg
11. Hugues Abriel
12. Dongchun Ni

Understanding and Predicting Ligand Efficacy in the μ-Opioid Receptor through Quantitative Dynamical Analysis of Complex Structures

1. Gabriel T. Galdino
2. Olivier Mailhot
3. Rafael Najmanovich

Cryo-EM structure of a blue-shifted channelrhodopsin from Klebsormidium nitens

1. Yuzhu Z. Wang
2. Koki Natsume
3. Tatsuki Tanaka
4. Shoko Hososhima
5. Rintaro Tashiro
6. Fumiya K. Sano
7. Hiroaki Akasaka
8. Satoshi P. Tsunoda
9. Wataru Shihoya
10. Hideki Kandori
11. Osamu Nureki

Structure of hepatitis B/D antiviral drug Bulevirtide bound to its receptor protein NTCP

1. Hongtao Liu
2. Dariusz Zakrzewicz
3. Kamil Nosol
4. Rossitza N. Irobalieva
5. Somnath Mukherjee
6. Rose Bang-Sørensen
7. Nora Goldmann
8. Sebastian Kunz
9. Lorenzo Rossi
10. Anthony A. Kossiakoff
11. Stephan Urban
12. Dieter Glebe
13. Joachim Geyer
14. Kaspar P. Locher

Propofol directly binds and inhibits skeletal muscle ryanodine receptor 1 (RyR1)

1. Thomas T. Joseph
2. Weiming Bu
3. Omid Haji-Ghassemi
4. Yu Seby Chen
5. Kellie Woll
6. Paul D. Allen
7. Grace Brannigan
8. Filip van Petegem
9. Roderic G. Eckenhoff

Capturing G protein-coupled receptors into native lipid-bilayer nanodiscs using new diisobutylene/maleic acid (DIBMA) copolymers

1. Ci Chu
2. Carolyn Vargas
3. Maria Carolina Barbosa
4. Simon Sommerhage
5. Gerald N. Rechberger
6. David Pahovnik
7. Ema Žagar
8. Gunnar F. Schröder
9. Sandro Keller
10. Manuel Etzkorn

Structural features of heteromeric channels composed of CALHM2 and CALHM4 paralogs

1. Katarzyna Drożdżyk
2. Martina Peter
3. Raimund Dutzler

• Curated by eLife

  eLife assessment

  In this interesting study, Drożdżyk and colleagues analyze the ability of placental CALHM orthologs to form stable complexes, identifying that CALHM2 and CALHM4 form heterooligomeric channels. The authors then determine cryo-EM structures of heterooligomeric CALHM2 and CALHM4 that reveal a distinct arrangement in which the two orthologs can interact, but preferentially segregate in the channel. This is an important study; the data provide compelling support for the interpretations and overall, the work is clearly described.

Reviewed by eLife

CryoRhodopsins: A comprehensive characterization of a group of microbial rhodopsins from cold environments

1. Gerrit H. U. Lamm
2. Egor Marin
3. Alexey Alekseev
4. Anna V. Schellbach
5. Artem Stetsenko
6. Jose Manuel Haro-Moreno
7. Gleb Bourenkov
8. Valentin Borshchevskiy
9. Marvin Asido
10. Michael Agthe
11. Sylvain Engilberge
12. Samuel L. Rose
13. Nicolas Caramello
14. Antoine Royant
15. Thomas R. Schneider
16. Alex Bateman
17. Thomas Mager
18. Tobias Moser
19. Francisco Rodriguez-Valera
20. Josef Wachtveitl
21. Albert Guskov
22. Kirill Kovalev