Reading List

PUFA stabilizes a conductive state of the selectivity filter in IKs channels

1. Alessia Golluscio
2. Jodene Eldstrom
3. Jessica J Jowais
4. Marta Elena Perez
5. Kevin Peter Cunningham
6. Alicia De La Cruz
7. Xiaoan Wu
8. Valentina Corradi
9. D Peter Tieleman
10. David Fedida
11. H Peter Larsson

• Curated by eLife

  eLife assessment

  This manuscript reveals an important mechanism of KCNQ1/IKs channel gating and PUFA modulation of this mechanism. This mechanism is supported by convincing single channel recordings, macroscopic current recordings and mutational analyses. These findings are of importance to the ion channel field and possibly future therapeutic applications.

Reviewed by eLife

Linkers in Bitopic Agonists Shape Bias Profile among Transducers for the Dopamine D2 and D3 Receptors

1. Ana Semeano
2. Rian Garland
3. Alessandro Bonifazi
4. Kuo Hao Lee
5. John Famiglietti
6. Wenqi Zhang
7. Yoon Jae Jo
8. Francisco O. Battiti
9. Lei Shi
10. Amy Hauck Newman
11. Hideaki Yano

Agonist efficacy at the β ₂ AR is driven by agonist-induced differences in receptor affinity for the G _s protein, not ligand binding kinetics

1. Clare R. Harwood
2. David A. Sykes
3. Theo Redfern-Nichols
4. Graham Ladds
5. Stephen J. Briddon
6. Dmitry B. Veprintsev

Photo-crosslinking hERG channels causes a U.V.-driven, state-dependent disruption of kinetics and voltage dependence of activation

1. Sara J. Codding
2. Matthew C. Trudeau

A comparative study of influenza A M2 protein conformations in DOPC/DOPS liposomes and in native E. coli membranes

1. Griffin Sanders
2. Peter P. Borbat
3. Elka R. Georgieva

Association between electrophysiological phenotypes and Kv2.1 potassium channel expression explained by geometrical analysis

1. Julio César Reyes-Garibaldi
2. Marco Arieli Herrera-Valdez

Mechanisms of Cholesterol Binding to LAT1

1. Keino Hutchinson
2. Avner Schlessinger

Direct interrogation of context-dependent GPCR activity with a universal biosensor platform

1. Remi Janicot
2. Marcin Maziarz
3. Jong-Chan Park
4. Jingyi Zhao
5. Alex Luebbers
6. Elena Green
7. Clementine Eva Philibert
8. Hao Zhang
9. Mathew D. Layne
10. Joseph C. Wu
11. Mikel Garcia-Marcos

Structure of a lasso peptide bound ETB receptor provides insights into the mechanism of GPCR inverse agonism

1. Wataru Shihoya
2. Hiroaki Akasaka
3. Peter A. Jordan
4. Anna Lechner
5. Bethany K. Okada
6. Gabriella Costa Machado da Cruz
7. Fumiya K. Sano
8. Tatsuki Tanaka
9. Ryo Kawahara
10. Rajan Chaudhari
11. Hiroko Masamune
12. Mark J. Burk
13. Osamu Nureki

Cryo-EM structure and biochemical analysis of human chemokine receptor CCR8

1. Qi Peng
2. Haihai Jiang
3. Xinyu Cheng
4. Na Wang
5. Sili Zhou
6. Yuting Zhang
7. Tingting Yang
8. Yixiang Chen
9. Wei Zhang
10. Sijia Lv
11. Weiwei Nan
12. JianFei Wang
13. Guo-Huang Fan
14. Jian Li
15. Jin Zhang

Reviewed by PREreview

Structural Basis of Voltage-Dependent Gating in BK Channels and Its Coupling to the Calcium Sensor

1. Gustavo F. Contreras
2. Rong Sheng
3. Ramon Latorre
4. Eduardo Perozo

Identification of the potassium-binding site in serotonin transporter

1. Eva Hellsberg
2. Danila Boytsov
3. Qingyang Chen
4. Marco Niello
5. Michael Freissmuth
6. Gary Rudnick
7. Yuan-Wei Zhang
8. Walter Sandtner
9. Lucy R. Forrest

Identification of SLC25A46 interaction interfaces with mitochondrial membrane fusogens Opa1 and Mfn2

1. Sivakumar Boopathy
2. Bridget E. Luce
3. Camila Makhlouta Lugo
4. Pusparanee Hakim
5. Julie McDonald
6. Ha Lin Kim
7. Jackeline Ponce
8. Beatrix M. Ueberheide
9. Luke H. Chao

Cryo-EM structure of monomeric CXCL12-bound CXCR4 in the active state

1. Yezhou Liu
2. Aijun Liu
3. Xinyu Li
4. Qiwen Liao
5. Weijia Zhang
6. Lizhe Zhu
7. Richard D. Ye

Dynamic conformational changes of acid-sensing ion channels in different desensitizing conditions

1. Caroline Marcher Holm
2. Asli B. Topaktas
3. Johs Dannesboe
4. Stephan A. Pless
5. Stephanie A. Heusser

High-Speed Atomic Force Microscopy Reveals Fluctuations and Dimer Splitting of the N-Terminal Domain of GluA2 Ionotropic Glutamate Receptor-Auxiliary Subunit Complex

1. Ayumi Sumino
2. Takashi Sumikama
3. Yimeng Zhao
4. Holger Flechsig
5. Kenichi Umeda
6. Noriyuki Kodera
7. Hiroki Konno
8. Motoyuki Hattori
9. Mikihiro Shibata

Hydrophobic residues in S1 modulate enzymatic function and voltage sensing in voltage-sensing phosphatase

1. Vamseedhar Rayaprolu
2. Heini M. Miettinen
3. William D. Baker
4. Victoria C. Young
5. Matthew Fisher
6. Gwendolyn Mueller
7. William O. Rankin
8. John T. Kelley
9. William J. Ratzan
10. Lee Min Leong
11. Joshua A. Davisson
12. Bradley J. Baker
13. Susy C. Kohout

The S-component fold: a link between bacterial transporters and receptors

1. Michele Partipilo
2. Dirk Jan Slotboom

High-resolution structures illuminate key principles underlying voltage and LRRC26 regulation of Slo1 channels

1. Gopal S. Kallure
2. Kamalendu Pal
3. Yu Zhou
4. Christopher J. Lingle
5. Sandipan Chowdhury

Structural basis of ligand specificity and channel activation in an insect gustatory receptor

1. Heather M. Frank
2. Sanket Walujkar
3. Richard M. Walsh
4. Willem J. Laursen
5. Douglas L. Theobald
6. Paul A. Garrity
7. Rachelle Gaudet