Preprint highlights April - May

A list by Sciety

A collection of the evaluated preprints we've been highlighting on social media.

39 articlesLast updated

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  1. Oxygen levels at the time of activation determine T cell persistence and immunotherapeutic efficacy

    1. Pedro P. Cunha
    2. Eleanor Minogue
    3. Lena C. M. Krause
    4. Rita M. Hess
    5. David Bargiela
    6. Brennan J. Wadsworth
    7. Laura Barbieri
    8. Carolin Brombach
    9. Iosifina P. Foskolou
    10. Ivan Bogeski
    11. Pedro Veliça
    12. Randall S. Johnson

    • Curated by eLife

      eLife assessment

      In the current manuscript, the authors study the effects of hypoxia or genetic and pharmacologic modulation of the hypoxic pathways on T cells. The findings about T cells sense hypoxia and how hypoxia affects T cell (and CAR T cell) differentiation and function are significant and interesting for the field. The data supporting these findings are mostly robust, yet some questions remain open and some statements seem unsupported by evidence.

    Reviewed by eLife

    5 evaluationsAppears in 3 listsLatest version Latest activity

  6. Regulation of chromatin microphase separation by adsorbed protein complexes

    1. Omar Adame-Arana
    2. Gaurav Bajpai
    3. Dana Lorber
    4. Talila Volk
    5. Samuel A. Safran

    • Curated by eLife

      eLife assessment

      This fundamental work substantially advances our understanding of polymer physics underpinnings of genome folding, organization, and regulation. The conclusions are supported by both convincing computer simulations and analytical theory. The work will be of significant interest to the genome folding community.

    Reviewed by eLife

    5 evaluationsAppears in 3 listsLatest version Latest activity

  7. Atf3 defines a population of pulmonary endothelial cells essential for lung regeneration

    1. Terren K. Niethamer
    2. Lillian I. Levin
    3. Michael P. Morley
    4. Apoorva Babu
    5. Su Zhou
    6. Edward E. Morrisey

    • Curated by eLife

      eLife Assessment

      The study has advanced our mechanistic understanding of lung regeneration. While the importance of regeneration of alveolar capillaries for long response to injury has been long recognized, the regulation of this process has not been well understood. Your study provides novel, comprehensive, and compelling evidence that the expression of the transcription factor Atf3 in alveolar capillary endothelial cells plays a critical role in the regeneration of alveolar capillaries following lung injury.

    Reviewed by eLife

    5 evaluationsAppears in 3 listsLatest version Latest activity

  12. Single cell RNA sequencing unravels the transcriptional network underlying zebrafish retina regeneration

    1. Laura Celotto
    2. Fabian Rost
    3. Anja Machate
    4. Juliane Bläsche
    5. Andreas Dahl
    6. Anke Weber
    7. Stefan Hans
    8. Michael Brand

    • Curated by eLife

      eLife assessment

      Müller glial cells of the zebrafish retina can differentiate into all neural cell classes following injury, providing full regenerative capabilities of the zebrafish retina. This valuable study presents a description of transcriptional changes of Müller glia cells in the adult and regenerating retina using single-cell RNA sequencing. The overall evidence supporting the main claims of the authors is solid.

    Reviewed by eLife

    7 evaluationsAppears in 3 listsLatest version Latest activity

  14. Courtship behaviour reveals temporal regularity is a critical social cue in mouse communication

    1. Catherine Perrodin
    2. Colombine Verzat
    3. Daniel Bendor

    • Curated by eLife

      eLife assessment

      This valuable work advances our understanding of the acoustic features driving the attraction of female mice to male vocalizations. The evidence supporting the conclusions is solid, with well-designed place preference assays and manipulations of male song structure. The work will be of broad interest to neurobiologists and ethologists working on mouse social interactions, auditory processing and communication.

    Reviewed by eLife

    4 evaluationsAppears in 3 listsLatest version Latest activity

  18. Rapid and precise genome engineering in a naturally short-lived vertebrate

    1. Ravi D. Nath
    2. Claire N. Bedbrook
    3. Rahul Nagvekar
    4. Karl Deisseroth
    5. Anne Brunet

    • Curated by eLife

      **eLife assessment
      **
      Within this paper, the authors describe a rapid and easy-to-implement CRISPR/Cas9-mediated knock-in approach to precisely insert large transgenes in the African turquoise killifish. The established method will be instrumental for many researchers working with unusual model species, and, in particular, will expand the killifish community toolbox. It will revolutionize the field and bring the killifish, an emerging animal model in aging biology and disease modeling in vertebrates, into the spotlight even more.

    Reviewed by eLife

    4 evaluationsAppears in 3 listsLatest version Latest activity
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