Preprint highlights April - May

A list by Sciety

A collection of the evaluated preprints we've been highlighting on social media.

39 articlesLast updated

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  1. Hypoxia-inducible factor 1 signaling drives placental aging and can provoke preterm labor

    1. Erin J Ciampa
    2. Padraich Flahardy
    3. Harini Srinivasan
    4. Christopher Jacobs
    5. Linus Tsai
    6. S Ananth Karumanchi
    7. Samir M Parikh

    • Curated by eLife

      eLife assessment

      This valuable study provides insights into mechanisms of placental aging and its relationship to labor initiation. The authors provide solid evidence and have thoroughly investigated the molecular characteristics of normal placental aging using in vivo and in vitro model systems and human placental tissue analysis to corroborate their findings. This work contributes to existing work in placental aging and preterm birth and will be of interest to reproductive scientists.

    Reviewed by eLife

    9 evaluationsAppears in 3 listsLatest version Latest activity

  5. The developmental basis for scaling of mammalian tooth size

    1. Mona M. Christensen
    2. Outi Hallikas
    3. Rishi Das Roy
    4. Vilma Väänänen
    5. Otto E. Stenberg
    6. Teemu J. Häkkinen
    7. Jean-Christophe François
    8. Robert J. Asher
    9. Ophir D. Klein
    10. Martin Holzenberger
    11. Jukka Jernvall

    Reviewed by preLights

    1 evaluationAppears in 2 listsLatest version Latest activity

  6. Insights into cargo sorting by SNX32 and its role in neurite outgrowth

    1. Jini Sugatha
    2. Amulya Priya
    3. Prateek Raj
    4. Ebsy Jaimon
    5. Uma Swaminathan
    6. Anju Jose
    7. Thomas John Pucadyil
    8. Sunando Datta

    • Curated by eLife

      eLife assessment

      This manuscript presents a series of important findings about the roles of the BAR-domain containing protein SNX32 in endosomal cargo sorting and in neurite outgrowth. The authors provide convincing evidence for their claims, which will be of interest for those working not only in membrane trafficking but also for cell biologists in general with interest in neurobiology.

    Reviewed by eLife

    4 evaluationsAppears in 3 listsLatest version Latest activity

  9. pYtags enable spatiotemporal measurements of receptor tyrosine kinase signaling in living cells

    1. Payam E Farahani
    2. Xiaoyu Yang
    3. Emily V Mesev
    4. Kaylan A Fomby
    5. Ellen H Brumbaugh-Reed
    6. Caleb J Bashor
    7. Celeste M Nelson
    8. Jared E Toettcher

    • Curated by eLife

      eLife assessment

      This is a well-explained and potentially useful study that describes the generation and use of pYtags, recombinant proteins that, if properly used, should allow spatiotemporal monitoring of the activation of different receptor tyrosine kinases in living cells. Although this study has generated new tools to evaluate receptor localization and activation in different cells, the broad concept showing that different receptor dimers generate specific stimuli, and downstream signaling pathways, is quite limited in terms of novelty. Although it is felt that the study is technologically innovative, the analysis of receptor spatial signaling is incomplete and should be improved.

    Reviewed by eLife

    5 evaluationsAppears in 3 listsLatest version Latest activity

  10. Concurrent remodelling of nucleolar 60S subunit precursors by the Rea1 ATPase and Spb4 RNA helicase

    1. Valentin Mitterer
    2. Matthias Thoms
    3. Robert Buschauer
    4. Otto Berninghausen
    5. Ed Hurt
    6. Roland Beckmann

    • Curated by eLife

      eLife assessment

      This fundamental study substantially advances our understanding of the process of ribosome maturation. The authors have purified and determined the structures of several nucleolar ribosome assembly intermediates in yeast using cryo-electron microscopy (cryo-EM). The study combines genetic, biochemical, and structural analysis to provide compelling support for the conclusions the authors wish to draw. The work will be of broad interest to cell biologists, biochemists, and structural biologists.

    Reviewed by eLife

    5 evaluationsAppears in 3 listsLatest version Latest activity

  13. Identification of a GABAergic neural circuit governing leptin signaling deficiency-induced obesity

    1. Yong Han
    2. Yang He
    3. Lauren Harris
    4. Yong Xu
    5. Qi Wu

    • Curated by eLife

      eLife assessment

      Leptin is a fat-derived hormone that curbs appetite, and mutation of leptin causes obesity and diabetes. This manuscript investigates leptin-responsive neural circuits, revealing a key inhibitory connection from leptin-sensitive neurons in the arcuate nucleus of the hypothalamus (AGRP neurons) to neurons in the dorsomedial hypothalamus. Toggling this inhibitory connection impacted leptin effects on feeding and metabolism. The study contains valuable data, including several interesting molecular genetic systems and the demonstration of GABA signaling in the DMH for the control of food intake, however, there is inadequate information about experimental design, including a lack of quantification and controls, and unjustified assumptions.

    Reviewed by eLife

    5 evaluationsAppears in 3 listsLatest version Latest activity

  15. Context-dependent requirement of G protein coupling for Latrophilin-2 in target selection of hippocampal axons

    1. Daniel T Pederick
    2. Nicole A Perry-Hauser
    3. Huyan Meng
    4. Zhigang He
    5. Jonathan A Javitch
    6. Liqun Luo

    • Curated by eLife

      eLife assessment

      This is an intriguing study investigating the molecular mechanisms of neural circuit developmental organization. Using a defined hippocampal circuit, the authors find that ectopic expression of an adhesion G protein-receptor leads to axon mistargeting. This work defines new mechanisms of axon target specificity.

    Reviewed by eLife

    5 evaluationsAppears in 3 listsLatest version Latest activity

  19. Dating the origin and spread of specialization on human hosts in Aedes aegypti mosquitoes

    1. Noah H Rose
    2. Athanase Badolo
    3. Massamba Sylla
    4. Jewelna Akorli
    5. Sampson Otoo
    6. Andrea Gloria-Soria
    7. Jeffrey R Powell
    8. Bradley J White
    9. Jacob E Crawford
    10. Carolyn S McBride

    • Curated by eLife

      eLife assessment

      This fundamental study by Rose and colleagues addresses key challenges in demographic inference in non-model systems with an innovative approach to model parameter calibration based on known historical events. Using this approach, they convincingly show that human specialization in Ae. aegypti mosquitoes likely evolved due to a past climate event around 5,000 years ago, and that recent rapid urbanization has continued to fuel its spread in West Africa in the past 20-40 years. This work will be of broad interest to population geneticists working on demographic inference, and to mosquito biologists working on the monitoring and control of this important vector species.

    Reviewed by eLife

    3 evaluationsAppears in 3 listsLatest version Latest activity