PREreview

Latest preprint reviews

1. InterPLM: discovering interpretable features in protein language models via sparse autoencoders

   This article has 2 authors:

   1. Elana Simon
   2. James Zou

   Reviewed by PREreview

2. Small molecule modulator of neuronal lysosome positioning and function resolves Alzheimer’s Disease-linked pathologies in cultured human neurons

   This article has 14 authors:

   1. Amanda M. Snead
   2. Sruchi Patel
   3. Mia Krout
   4. Ryan S. Hippman
   5. Gabrielle Smith
   6. Diya Dileep
   7. Nitya Chagoor
   8. Rachel Shi
   9. Ricardo Linares
   10. Andrew Dobria
   11. Stephanie M. Cologna
   12. Camerron Crowder
   13. Leslie N. Aldrich
   14. Swetha Gowrishankar

   Reviewed by PREreview

3. Maintenance of neuronal TDP-43 expression requires axonal lysosome transport

   This article has 20 authors:

   1. Veronica H Ryan
   2. Sydney Lawton
   3. Joel F Reyes
   4. James Hawrot
   5. Ashley M Frankenfield
   6. Sahba Seddighi
   7. Daniel M Ramos
   8. Jacob Epstein
   9. Faraz Faghri
   10. Nicholas L Johnson
   11. Jizhong Zou
   12. Martin Kampmann
   13. John Replogle
   14. Yue Andy Qi
   15. Hebao Yuan
   16. Kory Johnson
   17. Dragan Maric
   18. Ling Hao
   19. Mike A Nalls
   20. Michael Emmerson Ward

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this important manuscript, Ryan et al perform a genome-wide CRISPR based screen to identify genes that modulate TDP-43 levels in neurons. They identify a number of genes and pathways and highlight the BORC complex, which is required for anterograde lysosome transport as one such regulator of TDP-43 protein levels. Overall, this is a convincing study, which opens the door for additional future investigations on the regulation of TDP-43.

   Reviewed by eLife, PREreview

4. In-depth Analysis of Artificial Intelligence for Climate Change Mitigation

   This article has 1 author:

   1. Liyu Lu

   Reviewed by PREreview

5. Transforming Healthcare in Africa: The Role of Artificial Intelligence in Combatting Infectious Diseases, Neglected Tropical Diseases, and Antimicrobial Resistance

   This article has 4 authors:

   1. ANGYIBA ANDIGEMA
   2. NGNOTOUOM NGNOKAM Tania Cyrielle
   3. NDJIE Daniel Laetitia
   4. EWANE Ekwelle

   Reviewed by PREreview

6. AI for United Nations Sustainable Development Goals

   This article has 3 authors:

   1. Mirza Abdul Aleem Baig
   2. Jingchen Huang
   3. Jingzehua Xu

   Reviewed by PREreview

7. Theory of Differences Between Elements: Explanation of the Differences Between Quantum Physics and the Theory of General Relativity

   This article has 1 author:

   1. Carlos Eduardo Ramos Cardoso

   Reviewed by PREreview

8. Obligatory Necessity Theory: Elements and Facts Influenced by the Intensity of the Specific Physical Concept

   This article has 1 author:

   1. Carlos Eduardo Ramos Cardoso

   Reviewed by PREreview

9. Bricks or people? Investing more and better in Science, a dilemma for South American countries

   This article has 3 authors:

   1. Jose m. Paruelo
   2. Miguel Sierra
   3. Daniel Prieto

   Reviewed by PREreview

10. The Transformative Economic impact of Artificial Intelligence

    This article has 2 authors:

    1. Syed Adnan Jawaid
    2. Syed Ahmed

    Reviewed by PREreview