preLights

Latest preprint reviews

1. Hydration-dependent phase separation of a prion-like protein regulates seed germination during water stress

   This article has 13 authors:

   1. Yanniv Dorone
   2. Steven Boeynaems
   3. Benjamin Jin
   4. Flavia Bossi
   5. Eduardo Flores
   6. Elena Lazarus
   7. Emiel Michiels
   8. Mathias De Decker
   9. Pieter Baatsen
   10. Alex S. Holehouse
   11. Shahar Sukenik
   12. Aaron D. Gitler
   13. Seung Y. Rhee

   Reviewed by preLights

2. PACAP Induces Light Aversion in Mice by an Inheritable Mechanism Independent of CGRP

   This article has 9 authors:

   1. Adisa Kuburas
   2. Bianca N. Mason
   3. Benjamin Hing
   4. Anne-Sophie Wattiez
   5. Alyssa S. Reis
   6. Levi P. Sowers
   7. Cristina Moldovan Loomis
   8. Leon F. Garcia-Martinez
   9. Andrew F. Russo

   Reviewed by preLights

3. Hedgehog signaling is required for endomesodermal patterning and germ cell development in the sea anemone Nematostella vectensis

   This article has 4 authors:

   1. Cheng-Yi Chen
   2. Sean A McKinney
   3. Lacey R Ellington
   4. Matthew C Gibson

   Reviewed by preLights

4. Stress resets ancestral heritable small RNA responses

   This article has 4 authors:

   1. Leah Houri-Zeevi
   2. Guy Teichman
   3. Hila Gingold
   4. Oded Rechavi

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     In humans, extreme stresses, such as famine, can trigger multi-generational physiological responses through altered metabolism. In C. elegans, environmental stresses, such as heat shock, can similarly promote changes in gene expression and physiology. Here, the authors convincingly show that environmental stress can alter small RNA populations in such a manner that can alter gene expression over multiple generations. The work is beginning to tease out some of the mechanisms by which non-genetic information can regulate descendants biology.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife, preLights

5. Astrocytes close a motor circuit critical period

   This article has 4 authors:

   1. Sarah D. Ackerman
   2. Nelson A. Perez-Catalan
   3. Marc R. Freeman
   4. Chris Q. Doe

   Reviewed by preLights

6. Conditional Guide RNAs: Programmable Conditional Regulation of CRISPR/Cas Function in Bacterial and Mammalian Cells via Dynamic RNA Nanotechnology

   This article has 5 authors:

   1. Mikhail H. Hanewich-Hollatz
   2. Zhewei Chen
   3. Lisa M. Hochrein
   4. Jining Huang
   5. Niles A. Pierce

   Reviewed by preLights

7. Mouse embryonic stem cells self-organize into trunk-like structures with neural tube and somites

   This article has 16 authors:

   1. Jesse V. Veenvliet
   2. Adriano Bolondi
   3. Helene Kretzmer
   4. Leah Haut
   5. Manuela Scholze-Wittler
   6. Dennis Schifferl
   7. Frederic Koch
   8. Léo Guignard
   9. Abhishek Sampath Kumar
   10. Milena Pustet
   11. Simon Heimann
   12. René Buschow
   13. Lars Wittler
   14. Bernd Timmermann
   15. Alexander Meissner
   16. Bernhard G. Herrmann

   Reviewed by preLights

8. Probing the subcellular distribution of phosphatidylinositol reveals a surprising lack at the plasma membrane

   This article has 6 authors:

   1. James P. Zewe
   2. April M. Miller
   3. Sahana Sangappa
   4. Rachel C. Wills
   5. Brady D. Goulden
   6. Gerald R.V. Hammond

   Reviewed by preLights

9. An engineered transcriptional reporter of protein localization identifies regulators of mitochondrial and ER membrane protein trafficking in high-throughput CRISPRi screens

   This article has 10 authors:

   1. Robert Coukos
   2. David Yao
   3. Mateo I Sanchez
   4. Eric T Strand
   5. Meagan E Olive
   6. Namrata D Udeshi
   7. Jonathan S Weissman
   8. Steven A Carr
   9. Michael C Bassik
   10. Alice Y Ting

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Here authors present a robust, high-throughput and genome-wide strategy to identify genes that influence protein localization in individual subcellular compartments. The results profile subsets of genes that are involved in localization of tail-anchored proteins to mitochondrial and endoplasmic reticulum membranes and identify several unexpected regulators. This new tool is adaptable to studying various types of protein trafficking processes to shed light on their molecular mechanisms.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1, Reviewer #2 and Reviewer #3 agreed to share their names with the authors.)

   Reviewed by eLife, preLights

10. Heterogeneity in collective endothelial cell behavior is a driver of arterio-venous remodeling

    This article has 4 authors:

    1. Keyi Jiang
    2. Cathy Pichol-Thievend
    3. Zoltan Neufeld
    4. Mathias Francois

    Reviewed by preLights