eLife

Latest preprint reviews

1. Striatal Crosstalk Between Dopamine and Serotonin Systems

   This article has 3 authors:

   1. Yu Liu
   2. Juan Enriquez Traba
   3. Christian Lüscher

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful study employs optogenetics, genetically-encoded dopamine and serotonin sensors, and patch-clamp electrophysiology to investigate modulations of neurotransmitter release between striatal dopamine and serotonin neurons - a topic of interest to neuroscientists studying the basal ganglia. The results suggest that the dopamine and serotonin systems operate largely in parallel, with the activation of serotonin neurons resulting in a small, transient dopamine release. The authors suggest that this interaction occurs via glutamate release in the ventral tegmental area, findings that are closely related to previous work. Some conclusions are incomplete requiring larger samples-sizes and controls.

   Reviewed by eLife

2. High-throughput synapse profiling reveals cell-type-specific spatial configurations in the fly brain

   This article has 6 authors:

   1. Hongyang Wu
   2. Yoh Maekawa
   3. Sayaka Eno
   4. Shu Kondo
   5. Nobuhiro Yamagata
   6. Hiromu Tanimoto

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work introduces a splitGFP-based labeling tool with an analysis pipeline for the synaptic scaffold protein bruchpilot, with tests in the adult Drosophila mushroom bodies, a learning center in the Drosophila brain. The evidence supporting the conclusions is solid. However, additional controls, validation of synapse-specificity, validation of activity-dependence, details on image processing, and additional functional experiments are needed to strengthen the study.

   Reviewed by eLife

3. Developmental constraints mediate the summer solstice reversal of climate effects on European beech bud set

   This article has 9 authors:

   1. Dominic Rebindaine
   2. Thomas W. Crowther
   3. Susanne S. Renner
   4. Zhaofei Wu
   5. Yibiao Zou
   6. Lidong Mo
   7. Haozhi Ma
   8. Raymo Bucher
   9. Constantin M. Zohner

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This article presents valuable findings on how the timing of cooling affects the timing of autumn bud set in European beech saplings. The study leverages extensive experimental data and provides an interesting conceptual framework of the various ways in which warming can affect bud set timing. The support for the findings is incomplete, though extra justifications of the experimental settings, clarifications of the interpretation of the results, and alternative statistical analyses can make the conclusions more robust.

   Reviewed by eLife

4. Astrocytic modulation of population encoding in mouse visual cortex via GABA transporter 3 revealed by multiplexed CRISPR/Cas9 gene editing

   This article has 12 authors:

   1. Jiho Park
   2. Grayson O Sipe
   3. Xin Tang
   4. Prachi Ojha
   5. Giselle Fernandes
   6. Yi Ning Leow
   7. Caroline Zhang
   8. Yuma Osako
   9. Arundhati Natesan
   10. Gabrielle T Drummond
   11. Rudolf Jaenisch
   12. Mriganka Sur

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this manuscript, Park et al. developed a multiplexed CRISPR construct to genetically ablate the GABA transporter GAT3 in the mouse visual cortex, with effects on population-level neuronal activity. This work is important, as it sheds light on how GAT3 controls the processing of visual information. The findings are compelling, leveraging state-of-the-art gene CRISPR/Cas9, in vivo two-photon laser scanning microscopy, and advanced statistical modeling.

   Reviewed by eLife

5. PD-linked LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance via ERM hyperphosphorylation

   This article has 17 authors:

   1. Shiyi Wang
   2. Ryan Baumert
   3. Gabrielle Séjourné
   4. Dhanesh Sivadasan Bindu
   5. Kylie Dimond
   6. Kristina Sakers
   7. Leslie Vazquez
   8. Jessica L. Moore
   9. Christabel Xin Tan
   10. Tetsuya Takano
   11. Maria Pia Rodriguez
   12. Nick Brose
   13. Luke Bradley
   14. Reed Lessing
   15. Scott H. Soderling
   16. Albert R. La Spada
   17. Cagla Eroglu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study identifies astrocyte-intrinsic mechanisms by which the LRRK2 G2019S, a mutation linked to familial Parkinson's disease, disrupts synaptic integrity in the anterior cingulate cortex. The findings are convincing, as they rely on a comprehensive set of in vivo and in vitro genetic, biochemical, proteomic, and electrophysiological approaches. They are important because of their translational value, being validated in both mouse models and post-mortem human samples.

   Reviewed by eLife

6. Humans underestimate their body mass in microgravity: evidence from reaching movements during spaceflight

   This article has 8 authors:

   1. Zhaoran Zhang
   2. Yu Tian
   3. Chunhui Wang
   4. Changhua Jiang
   5. Bo Wang
   6. Hongqiang Yu
   7. Rui Zhao
   8. Kunlin Wei

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This paper undertakes an important investigation to determine whether movement slowing in microgravity is due to a strategic conservative approach or rather due to an underestimation of the mass of the arm. While the experimental dataset is unique and the coupled experimental and computational analyses comprehensive, the authors present incomplete results to support the claim that movement slowing is due to mass underestimation. Further analysis is needed to rule out alternative explanations.

   Reviewed by eLife

7. Development of Auditory and Spontaneous Movement Responses to Music over the First Year of Life

   This article has 8 authors:

   1. Trinh Nguyen
   2. Félix Bigand
   3. Susanne Reisner
   4. Atesh Koul
   5. Roberta Bianco
   6. Gabriela Markova
   7. Stefanie Hoehl
   8. Giacomo Novembre

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study offers important insights into the development of infants' responses to music based on the exploration of EEG neural auditory responses and video-based movement analysis. The convincing results revealed that evoked responses emerge between 3 and 12 months of age, but data analysis requires further refinement to fully complement the findings related to movement in response to music. This study will be of significant interest to developmental psychologists and neuroscientists, as well as researchers interested in music processing and in the translation of perception into action.

   Reviewed by eLife

8. Hippocampal single-cell RNA Atlas of chronic methamphetamine abuse-induced cognitive decline in mice

   This article has 6 authors:

   1. Hai Qiu
   2. Xia Yue
   3. Yuebing Huang
   4. Ziling Meng
   5. Jiahong Wang
   6. Dongfang Qiao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors proposed two hypotheses: first, that methamphetamine induces neuroinflammation, and second, that it alters neuronal stem cell differentiation. These are valuable hypotheses, and the authors provided in vivo observations of the methamphetamine response in mice. However, concerns remain regarding the interpretation of the data, and the current evidence is incomplete, requiring substantial experimental validation.

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9. A cortical–hippocampal communication undergoes rebalancing after new learning

   This article has 2 authors:

   1. Arron F Hall
   2. Dong V Wang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study investigates the neural basis of bidirectional communication between the cortex and hippocampus during learning. The evidence supporting the identification of specific circuits and functional cell types involved is convincing. However, certain aspects of the behavioral analysis and statistical interpretation remain incomplete. Overall, the work will be of interest to neuroscientists studying learning and memory.

   Reviewed by eLife

10. Unreliable homeostatic action potential broadening in cultured dissociated neurons

    This article has 16 authors:

    1. Andreas Ritzau-Jost
    2. Salil Rajayer
    3. Jana Nerlich
    4. Filip Maciag
    5. Alexandra John
    6. Michael Russier
    7. Victoria Gonzalez Sabater
    8. Luke J Steiger
    9. Jacques-Olivier Coq
    10. Jens Eilers
    11. Maren Engelhardt
    12. Juan Burrone
    13. Dominique Debanne
    14. Martin Heine
    15. Stephen M Smith
    16. Stefan Hallermann

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This study provides compelling evidence that action potential (AP) broadening is not a universal feature of homeostatic plasticity in response to chronic activity deprivation. By leveraging state-of-the-art methods across multiple brain regions and laboratories, the authors demonstrate that AP half-width remains largely stable, challenging previous assumptions in the field. These important findings help resolve longstanding inconsistencies in the literature and significantly advance our understanding of neuronal network homeostasis.

    Reviewed by eLife