eLife

Latest preprint reviews

1. Thermogenic Adipose ADH5 Counteracts Age-related Metabolic Decline

   This article has 12 authors:

   1. Sara C Sebag
   2. Tate Neff
   3. Qingwen Qian
   4. Arvand Asghari
   5. Zhuozhi Wang
   6. Zeyuan Zhang
   7. Mark Li
   8. Meihua Hao
   9. Vitor A Lira
   10. Hongli Sun
   11. Matthew J Potthoff
   12. Ling Yang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study identifies a brown adipose tissue-specific heat shock factor 1 (HSF1)-alcohol dehydrogenase 5 (ADH5) axis that regulates oxidative stress and cellular senescence during aging. The authors show that ADH5 deficiency drives BAT dysfunction and contributes to organismal health decline in aged mice. The evidence is convincing, and the work will be of broad interest to the adipose tissue and aging research communities.

   Reviewed by eLife

2. We couldn't get details of this article at this time:
   10.1101/2025.06.11.659043

3. We couldn't get details of this article at this time:
   10.1101/2024.10.22.619715

4. We couldn't get details of this article at this time:
   10.1101/2025.04.17.649150

5. We couldn't get details of this article at this time:
   10.1101/2024.07.18.601886

6. Punctuated mutagenesis promotes multi-step evolutionary adaptation in human cancers

   This article has 5 authors:

   1. Christopher Graser
   2. Wenbo Wu
   3. Cole Christini
   4. Mia Petljak
   5. Franziska Michor

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study presents a theoretical model of how punctuated mutations influence multistep adaptation, supported by empirical evidence from some TCGA cancer cohorts. This solid model points to the case of possible punctuated evolution rather than gradual genomic change. There was some disagreement amongst the reviewers in terms of how closely the theoretical results apply to the phenomena examined empirically, and alternative explanations should be considered in the future.

   Reviewed by eLife

7. We couldn't get details of this article at this time:
   10.1101/2025.07.23.666348

8. We couldn't get details of this article at this time:
   10.1101/2025.08.07.669231

9. Refining uncertainty about the TAK-003 dengue vaccine with a multi-level model of clinical efficacy trial data

   This article has 3 authors:

   1. Manar Alkuzweny
   2. Guido España
   3. T Alex Perkins

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This paper presents important new findings about the impact of the TAK-003 vaccine against dengue based on a convincing reanalysis of trial data. The results corroborate those of the original trial analyses, but with reduced uncertainty about the estimates of the impact of the vaccine. The findings will be of interest to clinicians, infectious disease epidemiologists, trial statisticians and policymakers seeking to understand the vaccine's efficacy profile and associated uncertainties.

   Reviewed by eLife

10. We couldn't get details of this article at this time:
    10.1101/2025.06.05.658048